Hydrogel–Nanolipid Formulations for the Complex Anti-Inflammatory and Antimicrobial Therapy of Periodontitis DOI Creative Commons

Rabia Ashfaq,

Norbert Tóth, Anita Kovács

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 620 - 620

Published: May 7, 2025

Objectives: This study aimed to develop and evaluate nanostructured lipid carriers (NLCs) loaded with meloxicam (Melox) a therapeutic antibacterial anti-inflammatory liquid lipid, clove oil (CO) for periodontitis treatment, complex inflammatory condition necessitating advanced drug delivery systems. The NLC–Melox formulation was integrated into three hydrogels, hypromellose (HPMC), zinc hyaluronate (ZnHA), sodium (NaHA), conduct comparative analysis focusing on enhanced localized delivery, improved mucoadhesion, prolonged retention, significant outcomes. Methods: prepared by homogenization characterized dynamic light scattering (DLS). Subsequently, NLC–Melox-loaded gels were subjected transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Raman spectroscopy, rheological analysis. In vitro release, activity (BSA denaturation assay), efficacy (MIC, MBC) investigated assess potential. Results: DLS revealed particle size of 183 nm polydispersity index 0.26, indicating homogeneity. TEM confirmed consistent morphology uniform nanoparticle distribution. DSC XRD demonstrated the amorphous nature Melox, enhancing solubility stability. Spectroscopy no chemical interactions between components. Rheological studies identified ZnHA as most mucoadhesive structurally stable gel. release showed sustained over 24 h. Melox CO-loaded formulations notable due oil. Conclusions: highlighted potential NLC-based hydrogels an effective strategy treatment. offered solubility, efficacy, mucoadhesivity, making it promising candidate therapy.

Language: Английский

Near-infrared-responsive copper-cerium bimetallic oxide nanozyme with antibacterial and antioxidant abilities for periodontitis therapy DOI
Xiaowen Li, H. Liang, Yonghui Huang

et al.

Colloids and Surfaces B Biointerfaces, Journal Year: 2025, Volume and Issue: unknown, P. 114685 - 114685

Published: April 1, 2025

Language: Английский

Citations

0
Hydrogel–Nanolipid Formulations for the Complex Anti-Inflammatory and Antimicrobial Therapy of Periodontitis DOI Creative Commons

Rabia Ashfaq,

Norbert Tóth, Anita Kovács

et al.

Pharmaceutics, Journal Year: 2025, Volume and Issue: 17(5), P. 620 - 620

Published: May 7, 2025

Objectives: This study aimed to develop and evaluate nanostructured lipid carriers (NLCs) loaded with meloxicam (Melox) a therapeutic antibacterial anti-inflammatory liquid lipid, clove oil (CO) for periodontitis treatment, complex inflammatory condition necessitating advanced drug delivery systems. The NLC–Melox formulation was integrated into three hydrogels, hypromellose (HPMC), zinc hyaluronate (ZnHA), sodium (NaHA), conduct comparative analysis focusing on enhanced localized delivery, improved mucoadhesion, prolonged retention, significant outcomes. Methods: prepared by homogenization characterized dynamic light scattering (DLS). Subsequently, NLC–Melox-loaded gels were subjected transmission electron microscopy (TEM), differential scanning calorimetry (DSC), X-ray diffraction (XRD), Raman spectroscopy, rheological analysis. In vitro release, activity (BSA denaturation assay), efficacy (MIC, MBC) investigated assess potential. Results: DLS revealed particle size of 183 nm polydispersity index 0.26, indicating homogeneity. TEM confirmed consistent morphology uniform nanoparticle distribution. DSC XRD demonstrated the amorphous nature Melox, enhancing solubility stability. Spectroscopy no chemical interactions between components. Rheological studies identified ZnHA as most mucoadhesive structurally stable gel. release showed sustained over 24 h. Melox CO-loaded formulations notable due oil. Conclusions: highlighted potential NLC-based hydrogels an effective strategy treatment. offered solubility, efficacy, mucoadhesivity, making it promising candidate therapy.

Language: Английский

Citations

0