Acta Pharmacologica Sinica, Journal Year: 2025, Volume and Issue: unknown

Published: May 19, 2025

Abstract Glutamate excitotoxicity is intricately linked to the pathogenesis of neurodegenerative diseases, exerting a profound influence on cognitive functions such as learning and memory in mammals. Glutamate, while crucial for these processes, can lead neuronal damage death when present excessive amounts. Our previous review delved into cascade excitotoxic injury events underlying mechanisms excitotoxicity. Building that foundation, this update summarizes latest research role diseases Alzheimer’s disease, Parkinson’s Huntington’s amyotrophic lateral sclerosis, well new cutting-edge techniques applied study We also explore action various inhibitors their clinical development status. This comprehensive analysis aims enhance our understanding nexus between offering valuable insights therapeutic strategies conditions.

Language: Английский