Stress-induced plasticity of a CRH/GABA projection disrupts reward behaviors in mice

Nature Communications, Journal Year: 2023, Volume and Issue: 14(1)

Published: Feb. 25, 2023

Disrupted operations of the reward circuit underlie major emotional disorders, including depression, which commonly arise following early life stress / adversity (ELA). However, how ELA enduringly impacts functions remains unclear. We characterize a stress-sensitive projection connecting basolateral amygdala (BLA) and nucleus accumbens (NAc) that co-expresses GABA stress-reactive neuropeptide corticotropin-releasing hormone (CRH). identify crucial role for this in executing disrupted behaviors provoked by ELA: chemogenetic optogenetic stimulation control male mice suppresses several behaviors, recapitulating deficits resulting from demonstrating pathway's contributions to normal behaviors. In adult mice, inhibiting-but not stimulating-the projection, restores typical yet has little effect controls, indicating ELA-induced maladaptive plasticity reward-circuit component. Thus, we discover stress-sensitive, inhibiting BLA → NAc with unique molecular features, may provide intervention targets disabling mental illnesses.

Language: Английский

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Hyperexcitation of ovBNST CRF neurons during stress contributes to female-biased expression of anxiety-like avoidance behaviors

Science Advances, Journal Year: 2024, Volume and Issue: 10(19)

Published: May 10, 2024

Corticotropin releasing factor (CRF) network in the oval nucleus of bed nuclei stria terminalis (ovBNST) is generally indicated stress, but its role female-biased susceptibility to anxiety unknown. Here, we established a stress paradigm. We found that CRF release ovBNST during showed pattern, and neurons were more prone be hyperexcited female mice both vitro vivo studies. Moreover, optogenetic modulation exchange activation pattern between male could reverse their anxiety. Last, receptor type 1 (CRFR1) mediated CRF-induced excitation expression. Specific knockdown CRFR1 level or overexpression Therefore, identify CRFR1-mediated hyperexcitation encode

Language: Английский

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Hypothalamic CRF neurons facilitate brain reward function

Current Biology, Journal Year: 2024, Volume and Issue: 34(2), P. 389 - 402.e5

Published: Jan. 1, 2024

Language: Английский

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Incentive motivation: ‘wanting’ roles of central amygdala circuitry

Behavioural Brain Research, Journal Year: 2021, Volume and Issue: 411, P. 113376 - 113376

Published: May 20, 2021

Language: Английский

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Neurodevelopmental origins of substance use disorders: Evidence from animal models of early‐life adversity and addiction

European Journal of Neuroscience, Journal Year: 2021, Volume and Issue: 55(9-10), P. 2170 - 2195

Published: April 7, 2021

Addiction is a chronic relapsing disorder with devastating personal, societal, and economic consequences. In humans, early-life adversity (ELA) such as trauma, neglect, resource scarcity are linked increased risk of later-life addiction, but the brain mechanisms underlying this link still poorly understood. Here, we focus on data from rodent models ELA in which causal effects responses to drugs neurodevelopmental by increases vulnerability addiction can be determined. We first summarize evidence for between then describe how commonly modeled rodents. Since heterogeneous disease many individually varying behavioral aspects that may impacted ELA, next discuss common assays addiction-like behaviors. specific addiction-relevant phenotypes caused male female rodents some changes reward stress circuits likely responsible. By better understanding neural promotes vulnerability, hope facilitate development new approaches preventing or treating those history ELA.

Language: Английский

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Opioid withdrawal: role in addiction and neural mechanisms

Psychopharmacology, Journal Year: 2023, Volume and Issue: 240(7), P. 1417 - 1433

Published: May 10, 2023

Language: Английский

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Acquiring competence from both extrinsic and intrinsic rewards

Learning and Instruction, Journal Year: 2024, Volume and Issue: 92, P. 101939 - 101939

Published: May 22, 2024

Language: Английский

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Distinct populations of corticotropin-releasing factor (CRF) neurons mediate divergent yet complementary defensive behaviors in response to a threat

Neuropharmacology, Journal Year: 2023, Volume and Issue: 228, P. 109461 - 109461

Published: Feb. 10, 2023

Language: Английский

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Dynorphin/kappa opioid receptor system regulation on amygdaloid circuitry: Implications for neuropsychiatric disorders

Frontiers in Systems Neuroscience, Journal Year: 2022, Volume and Issue: 16

Published: Oct. 5, 2022

Amygdaloid circuits are involved in a variety of emotional and motivation-related behaviors impacted by stress. The amygdala expresses several neuromodulatory systems, including opioid peptides their receptors. Dynorphin (Dyn)/kappa receptor (KOR) system has been implicated the processing stress-related information is expressed brain areas stress motivation. Dysregulation Dyn/KOR also various neuropsychiatric disorders. However, there limited about role regulating circuitry. Here, we review literature on (1) basic anatomy amygdala, (2) functional regulation synaptic transmission system, (3) anatomical architecture function (4) amygdala-dependent (5) future directions for field. Future work investigating how shapes wide range amygdala-related will be required to increase our understanding underlying circuitry modulation system. We anticipate that continued focus elucidate novel ways target treat

Language: Английский

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The central extended amygdala guides survival-relevant tradeoffs: Implications for understanding common psychiatric disorders

Neuroscience & Biobehavioral Reviews, Journal Year: 2022, Volume and Issue: 142, P. 104879 - 104879

Published: Sept. 15, 2022

Language: Английский

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