Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
26(8), P. 3031 - 3044
Published: May 27, 2024
Abstract
Depression
is
a
mood
disorder
that
may
increase
risk
for
the
development
of
insulin
resistance
(IR)
and
type
2
diabetes
(T2D),
vice
versa.
However,
mechanistic
pathway
linking
depression
T2D
not
fully
elucidated.
The
aim
this
narrative
review,
therefore,
was
to
discuss
possible
link
between
T2D.
coexistence
twice
as
great
compared
occurrence
either
condition
independently.
Hyperglycaemia
dyslipidaemia
promote
incidence
by
enhancing
inflammation
reducing
brain
serotonin
(5‐hydroxytryptamine
[5HT]).
Dysregulation
signalling
in
impairs
5HT
signalling,
leading
depression.
Furthermore,
associated
with
hyperglycaemia
poor
glycaemic
control.
Psychological
stress
In
conclusion,
could
be
potential
factor
through
induction
inflammatory
reactions
oxidative
affect
neurotransmission.
addition,
chronic
induce
dysregulation
hypothalamic–pituitary–adrenal
axis
circulating
cortisol
levels,
which
triggers
IR
Chemical Reviews,
Journal Year:
2023,
Volume and Issue:
124(1), P. 124 - 163
Published: Nov. 30, 2023
Psychedelics
make
up
a
group
of
psychoactive
compounds
that
induce
hallucinogenic
effects
by
activating
the
serotonin
2A
receptor
(5-HT2AR).
Clinical
trials
have
demonstrated
traditional
psychedelic
substances
like
psilocybin
as
class
rapid-acting
and
long-lasting
antidepressants.
However,
there
is
pressing
need
for
rationally
designed
5-HT2AR
agonists
possess
optimal
pharmacological
profiles
in
order
to
fully
reveal
therapeutic
potential
these
identify
safer
drug
candidates
devoid
effects.
This
Perspective
provides
an
overview
structure–activity
relationships
existing
based
on
their
chemical
classifications
discusses
recent
advancements
understanding
molecular
pharmacology
at
structural
level.
The
encouraging
clinical
outcomes
psychedelics
depression
treatment
sparked
discovery
endeavors
aimed
developing
novel
with
improved
subtype
selectivity
signaling
bias
properties,
which
could
serve
potentially
nonhallucinogenic
These
efforts
can
be
significantly
expedited
through
utilization
structure-based
methods
functional
selectivity-directed
screening.
Journal of Neuroinflammation,
Journal Year:
2023,
Volume and Issue:
20(1)
Published: March 27, 2023
Abstract
Depression
is
a
common
mental
illness,
which
related
to
monoamine
neurotransmitters
and
the
dysfunction
of
cholinergic,
immune,
glutamatergic,
neuroendocrine
systems.
The
hypothesis
one
commonly
recognized
pathogenic
mechanisms
depression;
however,
drugs
designed
based
on
this
have
not
achieved
good
clinical
results.
A
recent
study
demonstrated
that
depression
inflammation
were
strongly
correlated,
activation
alpha7
nicotinic
acetylcholine
receptor
(α7
nAChR)-mediated
cholinergic
anti-inflammatory
pathway
(CAP)
in
system
exhibited
therapeutic
effects
against
depression.
Therefore,
anti-inflammation
might
be
potential
direction
for
treatment
Moreover,
it
also
necessary
further
reveal
key
role
α7
nAChR
pathogenesis
This
review
focused
correlations
between
as
well-discussed
crucial
CAP.
Neurochemical Research,
Journal Year:
2023,
Volume and Issue:
48(11), P. 3255 - 3269
Published: July 13, 2023
Abstract
Multiple
sclerosis
(MS)
is
an
autoimmune
demyelinating
neurodegenerative
disease
of
the
central
nervous
system
(CNS)
due
to
injury
myelin
sheath
by
immune
cells.
The
clotting
factor
fibrinogen
involved
in
pathogenesis
MS
triggering
microglia
and
progress
neuroinflammation.
Fibrinogen
level
correlated
with
severity;
consequently,
inhibition
cascade
may
reduce
neuropathology.
Thus,
this
review
aimed
clarify
potential
role
how
targeting
affects
Accumulation
CNS
occur
independently
or
disruption
blood–brain
barrier
(BBB)
integrity
MS.
acts
as
transduction
increases
activation
which
induces
progression
inflammation,
oxidative
stress,
neuronal
injury.
Besides,
brain
impairs
remyelination
process
inhibiting
differentiation
oligodendrocyte
precursor
These
findings
proposed
that
associated
neuropathology
through
interruption
BBB
integrity,
induction
neuroinflammation,
demyelination
suppressing
oligodendrocytes.
Therefore,
and/or
CD11b/CD18
receptors
metformin
statins
might
decrease
In
conclusion,
expression
pro-inflammatory
effect
on
Frontiers in Molecular Neuroscience,
Journal Year:
2023,
Volume and Issue:
16
Published: July 4, 2023
This
review
focuses
on
neurotrophins
and
their
tyrosine
kinase
receptors,
with
an
emphasis
relevance
to
the
function
dysfunction
in
human
nervous
system.
It
also
deals
measurements
of
BDNF
levels
highlights
recent
findings
from
our
laboratory
TrkB
TrkC
signalling
neurons.
These
include
ligand
selectivity
Trk
activation
by
non-neurotrophin
ligands.
The
ligand-induced
down-regulation
re-activation
receptors
is
discussed.
Diabetes Obesity and Metabolism,
Journal Year:
2024,
Volume and Issue:
26(8), P. 3031 - 3044
Published: May 27, 2024
Abstract
Depression
is
a
mood
disorder
that
may
increase
risk
for
the
development
of
insulin
resistance
(IR)
and
type
2
diabetes
(T2D),
vice
versa.
However,
mechanistic
pathway
linking
depression
T2D
not
fully
elucidated.
The
aim
this
narrative
review,
therefore,
was
to
discuss
possible
link
between
T2D.
coexistence
twice
as
great
compared
occurrence
either
condition
independently.
Hyperglycaemia
dyslipidaemia
promote
incidence
by
enhancing
inflammation
reducing
brain
serotonin
(5‐hydroxytryptamine
[5HT]).
Dysregulation
signalling
in
impairs
5HT
signalling,
leading
depression.
Furthermore,
associated
with
hyperglycaemia
poor
glycaemic
control.
Psychological
stress
In
conclusion,
could
be
potential
factor
through
induction
inflammatory
reactions
oxidative
affect
neurotransmission.
addition,
chronic
induce
dysregulation
hypothalamic–pituitary–adrenal
axis
circulating
cortisol
levels,
which
triggers
IR
