Thalamic Dysconnectivity Across the Schizophrenia Illness Course and Psychosis Spectrum DOI
Samantha V. Abram, Caleb M. Spiro, Judith M. Ford

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 711 - 721

Published: Nov. 23, 2023

Abstract Abnormalities in thalamocortical connectivity are a robust feature of schizophrenia. These abnormalities reflected by both reduced between the thalamus and prefrontal cerebellar areas, as well increased sensory motor regions. There is also evidence for intra-thalamic among people with Thalamic present before onset full psychotic illness, severity has been found to predict conversion illness. an increasing appreciation thalamic disturbances representing transdiagnostic beyond categorical bounds This growing literature includes deviations those bipolar disorder, major depressive autism spectrum obsessive-compulsive disorder (among others). Future research needed clarify extent which aspects dysconnectivity, their corresponding behavioral clinical correlates, specific schizophrenia versus relevant across psychopathologies. Such knowledge can then inform development novel treatments aimed at functional consequences abnormalities.

Language: Английский

Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis DOI
Sidhant Chopra, Ashlea Segal, Stuart Oldham

et al.

JAMA Psychiatry, Journal Year: 2023, Volume and Issue: 80(12), P. 1246 - 1246

Published: Sept. 20, 2023

Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen progression, but the mechanisms underlying specific spatial patterning of these changes unknown.

Language: Английский

Citations

32
Exploratory analysis of the relationship between striatal connectivity and apathy during phosphodiesterase 10 inhibition in schizophrenia: findings from a randomized crossover trial DOI Creative Commons
Wolfgang Omlor,

Giacomo Cecere,

Gao-Yang Huang

et al.

BMC Medicine, Journal Year: 2025, Volume and Issue: 23(1)

Published: March 28, 2025

Negative symptoms in schizophrenia remain a challenge with limited therapeutic strategies. The novel compound RG7203 promotes reward learning via dopamine D1-dependent signaling and therefore holds promise, especially to improve the apathy dimension of negative symptoms. When tested as add-on antipsychotic medication, did not change significantly versus placebo. However, response varied across patients, subset showed clinically relevant improvement apathy. It remains unclear if these interindividual differences are related neurobiological correlates. Due predominant binding striatum, we investigated how changes cortico-striatal connectivity by computing rank correlations (rs). In post hoc exploratory analysis, focused on circuits that have been associated previously alterations schizophrenia. double-blind, 3-way randomized counterbalanced crossover study, resting-state functional magnetic resonance imaging was acquired from 24 individuals following 3-week administration placebo, 5 mg, or 15 mg an antipsychotics. We found lead significant striatal connectivity. were reflected changes. Apathy vs. placebo increased paracingulate (rs = - 0.58, p 0.047 for both doses) anterior cingulate regions 0.56, doses). Such associations observed symptom expressive deficits. additionally lower during linked greater treatment at doses 0.61-0.79 0.0002-0.02 These findings suggest gyrus cortex may be modulation under treatment. Replication further elaboration larger clinical studies could help advance biologically informed personalized options NCT02824055, registered ClinicalTrials.gov (2016-06-21).

Language: Английский

Citations

0
Pramipexole improves depression-like behavior in diabetes mellitus with depression rats by inhibiting NLRP3 inflammasome-mediated neuroinflammation and preventing impaired neuroplasticity DOI
Ping Li, Tingting Wang,

Haipeng Guo

et al.

Journal of Affective Disorders, Journal Year: 2024, Volume and Issue: 356, P. 586 - 596

Published: April 22, 2024

Language: Английский

Citations

3
Modulation of Dopaminergic Transmission and Brain Activity by Frontotemporal tDCS: A Multimodal PET-MR Imaging Study DOI Creative Commons
Clara Fonteneau, Inès Mérida, Jérôme Redouté

et al.

Brain stimulation, Journal Year: 2025, Volume and Issue: unknown

Published: May 1, 2025

Language: Английский

Citations

0
Brainwide Anatomical Connectivity and Prediction of Longitudinal Outcomes in Antipsychotic-Naïve First-Episode Psychosis DOI Creative Commons
Sidhant Chopra, Priscila T. Levi, Alexander Holmes

et al.

Biological Psychiatry, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

Citations

3
Subcortical influences on the topology of cortical networks align with functional processing hierarchies DOI Creative Commons
Fabian Hirsch,

Afra Wohlschläeger

NeuroImage, Journal Year: 2023, Volume and Issue: 283, P. 120417 - 120417

Published: Oct. 20, 2023

fMRI of the human brain reveals spatiotemporal patterns functional connectivity (FC), forming distinct cortical networks. Lately, subcortical contributions to these configurations are receiving renewed interest, but investigations rarely focus explicitly on their effects cortico-cortical FC. Here, we employ a straightforward multivariable approach and graph-theoretic tools assess impact topological features Given recent evidence showing that structures like thalamus basal ganglia integrate input from multiple networks, expect increased segregation between networks after removal FC patterns. We analyze resting state data young healthy participants (male female; N = 100) connectome project. find overall, network architecture becomes less segregated, more integrated, when influences accounted for. Underlying global following trends: 'Transmodal' systems become integrated with rest network, while 'unimodal' show opposite effect. For single nodes this hierarchical organization is reflected by close correspondence spatial layout principal gradient (Margulies et al., 2016). Lastly, limbic system significantly coherent removed. The findings validated in (split-sample) replication dataset. Our results provide new insight regarding interplay subcortex putting integrative context macroscale organization.

Language: Английский

Citations

5
Mapping alterations in the local synchrony of the cerebral cortex in schizophrenia DOI Creative Commons
Jesús Pujol,

Núria Pujol,

Anna Mané

et al.

European Psychiatry, Journal Year: 2023, Volume and Issue: 66(1)

Published: Jan. 1, 2023

Abstract Background Observations from different fields of research coincide in indicating that a defective gamma-aminobutyric acid (GABA) interneuron system may be among the primary factors accounting for varied clinical expression schizophrenia. GABA deficiency is locally expressed form neural activity desynchronization. We mapped functional anatomy local synchrony cerebral cortex schizophrenia using connectivity MRI. Methods Data 86 patients with and 137 control subjects were obtained publicly available repositories. Resting-state maps based on Iso-Distant Average Correlation measures across three distances estimated detailing structure cortex. Results Patients showed weaker (i.e., lower MRI signal synchrony) (i) prefrontal lobe areas, (ii) somatosensory, auditory, visual, motor cortices, (iii) paralimbic at anterior insula cingulate cortex, (iv) hippocampus. The distribution defect cortical area largely coincided synchronization effect agonist alprazolam previously observed identical measures. There was also notable resemblance between our findings areas showing higher density parvalbumin (prefrontal sensory cortices) somatostatin (anterior cortex) interneurons humans. Conclusions Our results thus provide detail changes suggest which elements are affected. Such information could ultimately relevant search specific treatments.

Language: Английский

Citations

4
Network-based spreading of grey matter changes across different stages of psychosis DOI Creative Commons
Sidhant Chopra, Ashlea Segal, Stuart Oldham

et al.

medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Jan. 12, 2022

Abstract Importance Psychotic illness is associated with anatomically distributed grey matter reductions that can worsen progression, but the mechanisms underlying specific spatial patterning of these changes unknown. Objective To test hypothesis brain network architecture constrains cross-sectional and longitudinal alterations across different stages psychotic to identify whether certain regions act as putative epicentres from which volume loss spreads. Design, Settings, Participants This study included 534 individuals 4 cohorts, spanning early late illness. Early-stage cohorts patients antipsychotic-naïve first episode psychosis (N=59) a group medicated within 3 years onset (N=121). Late-stage comprised two independent samples people established schizophrenia (N=136 in total). Each patient had corresponding matched control (N=218 A further sample healthy adults (N=346) was used derive representative structural functional networks for modelling network-based spreading processes. We additionally examined illness-related antipsychotic-related over 12 months using triple-blind randomised placebo-control MRI patients. All data were collected between April 2008 January 2020, analyses performed March 2021 2023. Main Outcomes Measures coordinated deformation models predict extent change each 332 parcellated areas by observed they structurally or functionally coupled. loss, we diffusion model simulate spread pathology seed regions. Correlations predicted empirical patterns quantify performance. Results In both illness, differences controls more accurately constrained structural, rather than functional, (. 46 < r .57; p .001). The same also robustly related ( > 52; .001) antipsychotic exposure .50; Diffusion consistently identified, all four datasets, anterior hippocampus epicentre pathological .05). Epicentres apparent posteriorly shifted anteriorly prefrontal cortex progression. Conclusion Relevance Our findings highlight robust central role white fibres conduits mirroring reported neurodegenerative conditions. connectome thus represents fundamental constraint on psychosis, regardless are caused medication. Moreover, dysfunction may affect connected areas. Key points Question Are continuum loss? Findings Across strongly brain’s axonal pathways identified source volume-loss Meaning White medial temporal play critical origins reductions.

Language: Английский

Citations

6
From operational diagnostic to dimensional-continuum concepts of psychotic and non-psychotic illness: Embracing catatonia across psychopathology and intrinsic movement disorder in neural network dysfunction DOI Creative Commons
John L. Waddington

Schizophrenia Research, Journal Year: 2022, Volume and Issue: 263, P. 99 - 108

Published: Oct. 13, 2022

Psychiatry is currently negotiating several challenges that are typified by (but not unique to) schizophrenia: do periodic refinements in operational diagnostic algorithms (a) resolve intricacies and subtleties within between psychotic non-psychotic disorders authentic impactful, or (b) constitute arbitrary porous boundaries should be complemented, even replaced, dimensional-continuum concepts of abnormality dysfunction. Critically, these issues relate only to apparent diagnoses but also those 'health' 'illness'. This article considers catatonia evolving approaches the description impairment dysfunction among disorders. It begins considering definition assessment vis-à-vis other disorders, followed its long-standing conjunction with schizophrenia, relationship antipsychotic drug treatment, transdiagnostic perspectives relationships, pathobiological processes. These appear involve across elements overlapping neural networks result a confluence psychopathology intrinsic hypo- hyperkinetic motor has been argued while current can have utility defining groups cases closely related, contemporary evidence indicates categorical divisions what essentially continuous landscape. Psychotic diagnoses, including catatonia, may reflect areas around points intersection orthogonal dimensions movement disorder poly-dimensional space characterises this landscape mental health

Language: Английский

Citations

4
Biomimetic model of corticostriatal micro-assemblies discovers new neural code DOI Creative Commons
Anand Pathak, Scott L. Brincat,

Haris Organtzidis

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 6, 2023

Although computational models have deepened our understanding of neuroscience, it is still highly challenging to link actual low-level physiological activity (spiking, field potentials) and biochemistry (transmitters receptors) with high-level cognitive abilities (decision-making, working memory) nor corresponding disorders. We introduce an anatomically-organized multi-scale model directly generating simulated physiology from which extended neural phenomena emerge. The produces spiking, fields, phase synchronies, synaptic change, memory, decisions, categorization, all were then validated on extensive experimental macaque data the received zero prior training any kind. Moreover, simulation uncovered a previously unknown code specifically predicting upcoming erroneous (“incongruous”) behaviors, also subsequently confirmed in empirical data. biomimetic thus predictively links novel decision reinforcement signals, interest, spiking codes, potential behavioral clinical relevance.

Language: Английский

Citations

2