IBRO Neuroscience Reports, Journal Year: 2024, Volume and Issue: 16, P. 622 - 628
Published: May 22, 2024
Language: Английский
Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)
Published: July 15, 2024
Abstract The rewards that we get from our choices and actions can have a major influence on future behavior. Understanding how reward biasing of behavior is implemented in the brain important for many reasons, including fact diminution hallmark clinical depression. We hypothesized mediated by anterior cingulate cortex (ACC), cortical hub region associated with integration executive control etiology To test this hypothesis, recorded neural activity during biased judgment task patients undergoing intracranial monitoring either epilepsy or depressive disorder. found beta (12–30 Hz) oscillations ACC predicted both size choice bias, also tracked receipt, thereby predicting bias trials. reduced magnitude depressed patients, whom beta-specific effects were correspondingly reduced. Our findings suggest may orchestrate learning information to guide adaptive choice, and, more broadly, potential biomarker anhedonia point development interventions enhance impact therapeutic benefit.
Language: Английский
Citations
3
Molecular Psychiatry, Journal Year: 2023, Volume and Issue: 29(1), P. 146 - 152
Published: Nov. 9, 2023
Language: Английский
Citations
8
Frontiers in Human Neuroscience, Journal Year: 2024, Volume and Issue: 17
Published: Jan. 12, 2024
Prefrontal circuits in the human brain play an important role cognitive and affective processing. Neuromodulation therapies delivered to certain key hubs within these are being used with increasing frequency treat a host of neuropsychiatric disorders. However, detailed neurophysiological effects stimulation largely unknown. Here, we performed intracranial recordings across prefrontal networks while delivering electrical two well-established white matter involved regulation depression: subcallosal cingulate (SCC) ventral capsule/ventral striatum (VC/VS). We demonstrate shared frontotemporal circuit consisting ventromedial cortex, amygdala, lateral orbitofrontal cortex where gamma oscillations differentially modulated by target. Additionally, found participant-specific responses dorsal anterior capacity for further tuning neural activity using current-steered stimulation. Our findings indicate potential mechanism dissociable therapeutic seen SCC VC/VS targets psychiatric neuromodulation our results lay groundwork personalized, network-guided neurostimulation therapy.
Language: Английский
Citations
2
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: June 8, 2024
In daily life, we must recognize others' emotions so can respond appropriately. This ability may rely, at least in part, on neural responses similar to those associated with our own emotions. We hypothesized that the insula, a cortical region near junction of temporal, parietal, and frontal lobes, play key role this process. recorded local field potential (LFP) activity human neurosurgical patients performing two tasks, one focused identifying their emotional response facial others. found matching patterns gamma- high-gamma band for tasks insula. Three other regions (MTL, ACC, OFC) clearly encoded both self- other-emotions, but used orthogonal do so. These results support hypothesis insula plays particularly important mediating between experienced vs. observed
Language: Английский
Citations
2
Brain stimulation, Journal Year: 2023, Volume and Issue: 16(6), P. 1764 - 1775
Published: Nov. 1, 2023
Identifying functional biomarkers related to treatment success can aid in expediting therapy optimization, as well contribute a better understanding of the neural mechanisms treatment-resistant depression (TRD) and subcallosal cingulate deep brain stimulation (SCC-DBS).Magnetoencephalography data were obtained from 16 individuals with SCC-DBS for TRD 25 healthy subjects. The first objective study was identify region-specific oscillatory modulations that both (i) discriminate (with OFF) controls, (ii) responders non-responders ON). second this work further explore effects intensity frequency on activity identified regions interest.Oscillatory power analyses led identification differentiated based increased alpha (8–12 Hz) decreased gamma (32–116 within nodes default mode, central executive, somatomotor networks, Broca's area, lingual gyrus. Within these nodes, it also found low had stronger modulation than intensity.The network implicate TRD-related involved emotional control/processing, motor control, interaction between speech, vision, memory, which have all been implicated depression. These electrophysiological potential be used proxies optimization. Additional parameter revealed strengthened by increasing or reducing frequency, may represent avenues direction non-responders.
Language: Английский
Citations
6
medRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown
Published: Nov. 8, 2023
A reliable physiological biomarker for Major Depressive Disorder (MDD) is necessary to improve treatment success rates by shoring up variability in outcome measures. In this study, we establish a passive that tracks with changes mood on the order of minutes hours. We record from intracranial electrodes implanted deep brain - surgical setting providing exquisite temporal and spatial sensitivity detect relationship difficult-to-measure area, ventromedial prefrontal cortex (VMPFC). The aperiodic slope power spectral density captures balance activity across all frequency bands construed as putative proxy excitatory/inhibitory brain. This study demonstrates how shifts correlate depression severity clinical trial stimulation treatment-resistant (TRD). correlation between scores significant N=5 subjects, indicating flatter (less negative) slopes correspond reduced severity, especially cortex. offers new way track patient response MDD treatment, facilitating individualized therapies both non-invasive monitoring scenarios.
Language: Английский
Citations
5
bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown
Published: March 29, 2024
Abstract Reduced cortical inhibition mediated by gamma-aminobutyric acid (GABA) is reported in depression, anxiety disorders, and aging. Novel positive allosteric modulator that specifically target α5-GABA A receptor subunit (α5-PAM), ligand GL-II-73, shows anxiolytic, antidepressant, pro-cognitive effects without the common side associated with non-specific modulation benzodiazepines such as diazepam (DZP), thus suggesting novel therapeutic potential. However, it unknown if α5-PAM has detectable signatures clinically-relevant brain electroencephalography (EEG). We analyzed EEG freely moving rats at baseline following injections of DZP. showed decreased theta peak power whereas DZP shifted from high to low theta, while increasing beta gamma power. decomposition these were periodic corresponded changes oscillation event duration. Our study robust distinct biomarkers rodents, indicating could enable non-invasive monitoring treatment efficacy.
Language: Английский
Citations
1
Operative Neurosurgery, Journal Year: 2024, Volume and Issue: unknown
Published: April 9, 2024
BACKGROUND AND OBJECTIVES: Recent advances in stereotactic and functional neurosurgery have brought forth the stereo-electroencephalography approach which allows deeper interrogation characterization of contributions deep structures to neural affective functioning. We argue that this can should be bear on notoriously intractable issue defining pathophysiology refractory psychiatric disorders developing patient-specific optimized stimulation therapies. METHODS: developed a suite methods for maximally leveraging an innovative application understand disorders, with high translatability across broader range neuropsychiatric conditions. RESULTS: This article provides roadmap determining desired electrode coverage, tracking high-resolution research recordings large number electrodes, synchronizing intracranial signals ongoing tasks other data streams, applying during recording, design choices patient comfort safety. CONCLUSION: These implemented conditions needing intensive electrophysiological define biomarkers more effectively guide therapeutic decision-making cases severe treatment-refractory disease.
Language: Английский
Citations
1
Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown, P. 403 - 449
Published: Jan. 1, 2024
Language: Английский
Citations
1
Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2024, Volume and Issue: 10(2), P. 186 - 194
Published: Nov. 14, 2024
A reliable physiological biomarker for Major Depressive Disorder is essential developing and optimizing neuromodulatory treatment paradigms. This study investigates a passive electrophysiologic that tracks changes in depressive symptom severity on the order of minutes to hours. We analyze brief recordings from intracranial electrodes implanted deep brain during clinical trial stimulation treatment-resistant depression 5 human subjects (nfemale= 3, nmale = 2). surgical setting allows precise temporal spatial sensitivity ventromedial prefrontal cortex, challenging area measure. focused aperiodic slope power spectral density, metric reflecting balance activity across all frequency bands serving as proxy excitatory/inhibitory brain. Our findings demonstrate shifts correlate with severity, flatter (less negative) slopes indicating reduced severity. significant correlation was observed N=5 subjects, particularly cortex. offers new way track patient responses treatment, paving individualized therapies both non-invasive monitoring contexts.
Language: Английский
Citations
1