medRxiv (Cold Spring Harbor Laboratory),
Journal Year:
2024,
Volume and Issue:
unknown
Published: Oct. 7, 2024
Abstract
In
this
double-blind
placebo-controlled
randomised
intervention
we
investigated
the
potential
benefits
of
a
prebiotic
supplement
on
children’s
well-being
in
home
setting.
The
primary
aim
was
to
determine
if
could
effectively
reduce
anxiety,
improve
mood,
and
enhance
cognitive
function,
similar
findings
young
adults.
Fifty-three
healthy
children,
aged
6
14,
participated
an
8-week
trial.
trial
consisted
three
testing
time
points;
day
zero
marked
baseline
measurement
(T1)
followed
by
28-day
period
during
which
they
consumed
5.5
grams
galactooligosaccharides
(GOS)
daily
under
parental
guidance.
Endline
measures
(T2)
were
conducted
last
consumption,
with
final
follow-up
session
(T3)
56.
Primary
outcomes
trait
anxiety
using
questionnaire
emotional
behavior
dot-probe
task
responses
positive
negative
images.
Secondary
encompassed
depression
levels,
function
tests,
dietary
intake
recorded
4-day
food
diary.
Additionally,
explored
whether
parents’
had
impact
responses.
While
our
statistical
analysis
did
not
reveal
significant
effects
GOS,
there
noteworthy
trends.
Trait
levels
decreased
over
both
groups,
more
pronounced
decrease
GOS
group.
group
exhibited
reduced
compared
placebo
group,
post-trial
time.
Although
correlated
various
influence
effects.
conclusion,
these
suggest
trends
line
hypotheses
however
further
investigation
greater
power
would
be
beneficial.
Frontiers in Nutrition,
Journal Year:
2024,
Volume and Issue:
11
Published: March 5, 2024
Medicine
often
employs
the
4Ps
of
predisposing,
precipitating,
perpetuating
,
and
protective
factors
to
identify
salient
influences
on
illness
states,
help
guide
patient
care.
Mental
is
a
significant
cause
morbidity
mortality
worldwide.
health
complex
combination
biological,
psychological,
environmental,
social
factors.
There
growing
interest
in
gut-brain-microbiome
(GBM)
axis
its
impact
mental
health.
We
use
medical
model
explore
involving
connection
between
nutrition
GBM
their
associated
risks
with
problems
emerging
adults
(EAs),
life
stage
when
onset
most
common.
review
current
dietary
trends
health,
role
that
gut
microbiome-based
interventions
can
have
modulating
EAs.
discuss
implications
areas
for
clinical
intervention.
European Child & Adolescent Psychiatry,
Journal Year:
2025,
Volume and Issue:
unknown
Published: Jan. 29, 2025
Abstract
Predictors
for
the
pharmacological
effect
of
ADHD
medication
in
children
and
adolescents
are
lacking.
This
study
examined
clinically
relevant
factors
a
large
(N
=
638)
prospective
cohort
reflecting
real-world
evidence.
Children
aged
6–17
diagnosed
with
were
evaluated
at
baseline
three
months
following
initiation.
The
outcome
was
measured
as
reduction
total
SNAP-IV
(Swanson
Nolan
Pelham
teacher
parent
rating
scale)
score
compared
to
baseline.
Outcome
groups
defined
Responders
(≥
40%
reduction),
Intermediate
20
<
Non-responders
(<
20%
reduction).
Included
independent
variables
Autism
Spectrum
Questionnaire
(ASSQ),
Spence
Children’s
Anxiety
Scale
(SCAS),
Pediatric
Side
Effect
Checklist
(P-SEC),
anthropometrics
measures,
geographical
region,
relative
age,
Children´s
Global
Assessment
(CGAS),
Intelligence
quotient
(IQ),
treatment
initiation
month,
symptom
severity,
presentation,
psychotic-like
experiences.
Multinomial
logistic
regression
suggested
that
stating
three-month
follow-up
associated
response
group.
However,
when
validating
data
Bootstrap
Forest,
none
significant.
Thus,
our
naturalistic
cohort,
we
could
not
identify
any
reliably
predict
outcomes.
Trial
registration
:
NCT02136147.
Nutrition Journal,
Journal Year:
2025,
Volume and Issue:
24(1)
Published: March 1, 2025
In
this
double-blind
placebo-controlled
randomised
intervention
we
investigated
the
potential
benefits
of
a
prebiotic
supplement
on
children's
well-being
in
home
setting.
The
primary
aim
was
to
determine
if
could
effectively
reduce
anxiety,
improve
mood,
and
enhance
cognitive
function,
similar
findings
young
adults.
Fifty-three
healthy
children,
aged
6
14,
participated
an
8-week
trial.
trial
consisted
three
testing
time
points;
day
zero
marked
baseline
measurement
(T1)
followed
by
28-day
period
during
which
they
consumed
5.5
g
galactooligosaccharides
(GOS)
daily
under
parental
guidance.
Endline
measures
(T2)
were
conducted
last
consumption,
with
final
follow-up
session
(T3)
56.
Primary
outcomes
trait
anxiety
using
questionnaire
emotional
behavior
dot-probe
task
responses
positive
negative
images.
Secondary
encompassed
depression
levels,
function
tests,
dietary
intake
recorded
4-day
food
diary.
Additionally,
explored
whether
parents'
had
impact
responses.
While
our
statistical
analysis
did
not
reveal
significant
effects
GOS,
there
noteworthy
trends.
Trait
levels
decreased
over
both
groups,
more
pronounced
decrease
GOS
group
(after
intervention,
p
=.090;
after
follow-up,
=.031).
exhibited
reduced
compared
placebo
(p
=.105),
post-trial
=.015).
Although
correlated
various
influence
effects.
These
suggest
trends
line
hypotheses,
however
further
investigation
greater
power
would
be
beneficial.
Retrospectively
registered
https://clinicaltrials.gov/
[NCT06258135]
February
6,
2024.
Gut,
Journal Year:
2024,
Volume and Issue:
73(12), P. 1953 - 1964
Published: Aug. 9, 2024
IBD
is
characterised
by
dysbiosis,
but
it
remains
unclear
to
what
extent
dysbiosis
develops
in
unaffected
at-risk
individuals.
To
address
this,
we
investigated
age-related
patterns
of
faecal
and
serum
markers
high-risk
multiplex
families
(two
or
more
affected
first-degree
relatives).
Brain Sciences,
Journal Year:
2023,
Volume and Issue:
13(12), P. 1632 - 1632
Published: Nov. 24, 2023
Studies
in
the
field
of
experimental
hypnosis
highlighted
role
hypnotizability
physiological
variability
general
population.
It
is
associated,
fact,
with
a
few
differences
which
are
observable
ordinary
state
consciousness
and
absence
suggestions.
The
aim
present
scoping
review
summarizing
them
indicate
their
relevance
to
neural
mechanisms
prognosis
treatment
medical
conditions.
Individuals
high,
medium
low
scores
display
different
cerebral
functional
differences-i.e.,
equivalence
between
imagery
perception/action,
excitability
motor
cortex,
interoceptive
accuracy-possibly
related
brain
structural
characteristics,
control
blood
supply
at
peripheral
level,
likely
due
availability
endothelial
nitric
oxide.
These
reviewed
support
idea
participation
hypnotic
behaviour
prognostic
therapeutic
usefulness
