Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Language: Английский

Locus Coeruleus Degeneration in Essential Tremor With Mild Cognitive Impairment: A Neuromelanin MRI Study DOI Creative Commons

Yuelin Fang,

Cheng Zhou,

Bingting Zhu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(1)

Published: Jan. 1, 2025

ABSTRACT Objective Our aim was to research the neuromelanin‐sensitive magnetic resonance imaging (NM‐MRI) features of locus coeruleus (LC) in essential tremor (ET) patients various cognitive states and explore relationships between these cognition. Methods We recruited three groups participants, including 30 ET with mild impairment (ET‐MCI), 57 normal cognition (ET‐NC), 105 healthy controls (HCs). All participants underwent MRI scanning clinical evaluation. Through NM‐MRI images, we compared contrast‐to‐noise ratio LC (CNR ) evaluated CNR scales. Results Compared HCs, ET‐MCI had a substantially lower value ( p = 0.017). The ET‐NC intermediate that HCs. Furthermore, partial correlation analysis patients, controlling for age, gender, education level, showed higher values correlate better performance on Montreal assessment test trail making A. Conclusion degeneration may partially contribute decline, suggesting norepinephrine system deserves further mechanism decline as well development targeted drugs.

Language: Английский

Citations

0
Neuromelanin-sensitive MRI for mechanistic research and biomarker development in psychiatry DOI
Kenneth Wengler, Paula Trujillo, Clifford Cassidy

et al.

Neuropsychopharmacology, Journal Year: 2024, Volume and Issue: 50(1), P. 137 - 152

Published: Aug. 19, 2024

Language: Английский

Citations

3
Neuromelanin MRI Contrast in Patients with Treatment-Resistant Schizophrenia: A Cross-Sectional Study DOI
Fumihiko Ueno,

Shiori Honda,

Shinichiro Nakajima

et al.

Published: Jan. 1, 2025

Language: Английский

Citations

0
Locus coeruleus activation 'resets' hippocampal event representations and separates adjacent memories DOI Creative Commons
David Clewett, Ringo Huang, Lila Davachi

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 18, 2024

Memories reflect the ebb and flow of experiences, capturing unique meaningful events from our lives. Using a combination functional magnetic resonance imaging (fMRI), neuromelanin imaging, pupillometry, we show that arousal locus coeruleus (LC) activation transform otherwise continuous experiences into distinct episodic memories. As sequences unfold, encountering context shift, or event boundary, triggers LC processes predict later memory separation. Boundaries furthermore promote temporal pattern separation within left hippocampal dentate gyrus, which correlates with heightened responses to those same transition points. We also find neurochemical index prolonged diminished at boundaries, suggesting connection between elevated output impaired processing. These findings align idea initiate neural reset in response significant changes, constructing very episodes define everyday memory.

Language: Английский

Citations

0