Early postnatal NMDA receptor ablation in cortical interneurons impairs affective state discrimination and social functioning

Neuropsychopharmacology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 20, 2025

Language: Английский

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Perturbations in the microbiota-gut-brain axis shaped by social status loss

Communications Biology, Journal Year: 2025, Volume and Issue: 8(1)

Published: March 8, 2025

Abstract Social status is closely linked to physiological and psychological states. Loss of social dominance can lead brain disorders such as depression, but the underlying mechanisms remain unclear. The gut microbiota sense stress contribute via microbiota-gut-brain axis (MGBA). Here, using a forced loss paradigm demote dominant mice subordinate ranks, we find that alters composition function microbiota, increasing Muribaculaceae abundance enhancing butanoate metabolism, microbial depletion resists loss-induced hierarchical demotion behavioral alteration. Single-nucleus transcriptomic analysis prefrontal cortex (PFC) indicates primarily affected interneurons, altering GABAergic synaptic transmission. Weighted gene co-expression network (WGCNA) reveals modules in colon, PFC, PFC suggesting changes PI3K-Akt signaling pathway glutamatergic synapse. Our findings provide evidence for MGBA perturbations induced by loss, offering potential intervention targets related disorders.

Language: Английский

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Somatostatin-expressing interneurons of prefrontal cortex modulate social deficits in the Magel2 mouse model of autism

Molecular Autism, Journal Year: 2025, Volume and Issue: 16(1)

Published: March 11, 2025

Dysfunction in social interactions is a core symptom of autism spectrum disorder (ASD). Nevertheless, the neural mechanisms underlying deficits ASD are poorly understood. By integrating electrophysiological, vivo fiber photometry, viral-mediated tracing, optogenetic and pharmacological stimulation, we show reduced intrinsic excitability hypoactivity SOM interneurons medial prefrontal cortex (mPFC) Magel2-deficient mice, an established model, were required to defects. Chemogenetic inhibition mPFC SOM-containing resulted interaction wild-type Magel2 mice. These sociability can be rescued by activation mPFCSOM-LS inhibitory pathway Magel 2 knockout results demonstrate for action impairments, suggest targeting this mechanism that may prove therapeutically beneficial mitigating behavioral disturbances observed ASD.

Language: Английский

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Untersuchung des Sozialverhaltens in einem Rattenmodell der bipolaren Störung

Pharmacopsychiatry, Journal Year: 2025, Volume and Issue: 58(03), P. 140 - 140

Published: April 30, 2025

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Transformations in prefrontal ensemble activity underlying rapid threat avoidance learning

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Aug. 30, 2024

The capacity to learn cues that predict aversive outcomes, and understand how avoid those is critical for adaptive behavior. Naturalistic avoidance often means accessing a safe location, but whether location depends on the nature of impending threat. These relationships must be rapidly learned if animals are survive. prelimbic subregion (PL) medial prefrontal cortex (mPFC) integrates associations influence these threat strategies. Prior work has focused role PL activity in behaviors fully established, leaving mechanisms drive rapid learning poorly understood. To determine when learning-related changes emerge, we recorded neural using miniscope calcium imaging as mice threatening cue by location. Over course learning, observed enhanced modulation representing intersections with or risky locations movements between them. We population dynamics preceded observable encoding individual neurons. Successful could predicted from cue-related during early learning. Population specific epochs conditioned tone period correlated modeled rates animals. In contrast, single-neuron occurred later, once an strategy had stabilized. Together, our findings reveal sequence characterize

Language: Английский

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Visual identification of conspecifics shapes social behavior in mice

Current Biology, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 1, 2024

Language: Английский

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Visual Identification of Conspecifics Shapes Social Behavior in Mice

Published: Jan. 1, 2024

Language: Английский

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Visual Identification of Conspecifics Shapes Social Behavior in Mice

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: June 8, 2024

Summary Recognizing conspecifics in order to determine how interact with them appropriately is a fundamental goal of animal sensory systems. It has undergone selective pressure nearly all species. Mice have large repertoire social behaviors that are the subject rapidly growing field study neuroscience. Mouse interactions likely incorporate available modalities, and vast majority studies not attempted isolate them. Specifically role vision mouse remains unclear. We developed behavioral platform allowed us present visual information stimulus mice isolation from olfactory, acoustic, tactile cues. Our results indicate identification sex or individual identity other influences behavior. These findings highlight underappreciated open new avenues circuits underlying

Language: Английский

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Clemastine improves emotional and social deficits in adolescent social isolation mice by reversing demyelination

Pharmacology Biochemistry and Behavior, Journal Year: 2024, Volume and Issue: 242, P. 173824 - 173824

Published: Sept. 1, 2024

Language: Английский

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