SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression DOI
Hongbo Yu, Xinping Li, Bo Ning

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 328 - 340

Published: Oct. 29, 2024

Coronary heart disease (CHD) combined with anxiety or depression is increasingly receiving attention in the clinical field of cardiology, and exploring comorbidity pathological mechanisms cardiovascular psychological disorders a hot research topic for scholars this field. Current suggests that Silent Information Regulatory Factor 1 (SIRT1) may serve as potential biomarker mechanism treatment CHD depression. SIRT1 considered promising therapeutic target depression, ability to regulate inflammatory cytokine levels, alleviate oxidative stress damage, activate multiple signalling pathways, reduce platelet hyperresponsiveness, exert neuroprotective cardioprotective effects. In comprehensive review, we deeply studied structure, function, SIRT1, discussed its protective effects nervous system. The latest progress SIRT1's role was emphasised, including specific regulating response, alleviating stress, mediating various pathways. addition, article also summarises patients

Language: Английский

The nucleus accumbens in reward and aversion processing: insights and implications DOI Creative Commons
Ying Xu, Yingjie Lin, Ming Yu

et al.

Frontiers in Behavioral Neuroscience, Journal Year: 2024, Volume and Issue: 18

Published: Aug. 9, 2024

The nucleus accumbens (NAc), a central component of the brain's reward circuitry, has been implicated in wide range behaviors and emotional states. Emerging evidence, primarily drawing from recent rodent studies, suggests that function NAc aversion processing is multifaceted. Prolonged stress or drug use induces maladaptive neuronal which results pathological conditions. This review aims to provide comprehensive up-to-date insights on role motivated behavior regulation highlights areas demand further in-depth analysis. It synthesizes latest findings how distinct populations pathways contribute opposite valences. examines neuromodulators, especially monoamines, influence NAc's control over various motivational Furthermore, it delves into complex underlying mechanisms psychiatric disorders such as addiction depression evaluates prospective interventions restore functionality.

Language: Английский

Citations

9
Unveiling the role of histone deacetylases in neurological diseases: focus on epilepsy DOI Creative Commons

Danfeng Cao,

Xinyu Zhou, Qian Guo

et al.

Biomarker Research, Journal Year: 2024, Volume and Issue: 12(1)

Published: Nov. 19, 2024

Abstract Epilepsy remains a prevalent chronic neurological disease that is featured by aberrant, recurrent and hypersynchronous discharge of neurons poses great challenge to healthcare systems. Although several therapeutic interventions are successfully utilized for treating epilepsy, they can merely provide symptom relief but cannot exert disease-modifying effect. Therefore, it urgent need explore other potential mechanism develop novel approach delay the epileptic progression. Since approximately 30 years ago, histone deacetylases (HDACs), versatile epigenetic regulators responsible gene transcription via binding histones or non-histone substrates, have grabbed considerable attention in drug discovery. There also substantial evidences supporting aberrant expressions and/activities HDAC isoforms reported epilepsy inhibitors (HDACi) been purposes this condition. However, specific mechanisms underlying role HDACs progression not fully understood. Herein, we reviewed basic information HDACs, summarized recent findings associated with roles diverse subunits discussed regulatory which affected development epilepsy. Additionally, provided brief discussion on as promising targets treatment, serving valuable reference study clinical translation field.

Language: Английский

Citations

8
Role of sirtuin 1 in depression‑induced coronary heart disease: Molecular pathways and therapeutic potential (Review) DOI Open Access

Shijie Zheng,

Linlin Yang,

Qiuting Dai

et al.

Biomedical Reports, Journal Year: 2025, Volume and Issue: 22(3)

Published: Jan. 14, 2025

Depression and coronary heart disease (CHD) are two interconnected diseases that profoundly impact global health. is both a complex psychiatric disorder an established risk factor for CHD. Sirtuin 1 (SIRT1) enzyme requires the cofactor nicotinamide adenine dinucleotide (NAD+) to perform its deacetylation function, involvement crucial in reducing cardiovascular risks associated with depression. SIRT1 exerts cardioprotective effects via modulating oxidative stress, inflammation metabolic processes, all of which central pathogenesis CHD individuals Through influencing these pathways, helps reduce endothelial dysfunction, prevent formation atherosclerotic plaques stabilize existing plaques, thereby decreasing overall The present review underscores important role serving as therapeutic intervention molecule tackling complications stemming from Furthermore, it highlights need further studies clarify how influences depression at molecular level. ultimate goal this research will be translate findings into practical clinical strategies.

Language: Английский

Citations

0
Genetic, Epigenetic, and Hormonal Regulation of Stress Phenotypes in Major Depressive Disorder: From Maladaptation to Resilience DOI Creative Commons

Anushka Arvind,

S Sreelekshmi,

Neelima Dubey

et al.

Cellular and Molecular Neurobiology, Journal Year: 2025, Volume and Issue: 45(1)

Published: March 26, 2025

Language: Английский

Citations

0
Alleviation of Microglia Mediating Hippocampal Neuron Impairments and Depression‐Related Behaviors by Urolithin B via the SIRT1‐FOXO1 Pathway DOI Creative Commons
Cuilan Liu,

Di Zhao,

Garrett Yu

et al.

CNS Neuroscience & Therapeutics, Journal Year: 2025, Volume and Issue: 31(4)

Published: April 1, 2025

ABSTRACT Aims Conventional antidepressants exhibit limited efficacy and delayed onset. This study aimed to elucidate the antidepressant effects of urolithin B (UB) its regulatory role in microglia‐mediated hippocampal neuronal dysfunction. Methods The mouse model depression was established using both chronic unpredicted stress (CUS) lipopolysaccharide (LPS) injection. therapeutic UB assessed through behavioral paradigms. microglia activation, cellular cytotoxicity apoptosis levels, underlying molecular mechanisms were delineated utilizing proteomics analysis, immunofluorescence staining, real‐time PCR Western blotting. Results efficiently alleviated depression‐related behaviors, accompanied by suppressed neuroinflammation, changes classic activation (M1)/alternative (M2) polarization recovered sirtuin‐1 (SIRT1) forkhead box protein O1 (FOXO1) expression hippocampus. Additionally, reduced HT22 cells phenotypes treated supernatant from LPS‐incubated BV2 cells, which mediated SIRT1‐FOXO1 pathway. analysis content revealed abundant secreting proteins among LPS/UB application. Conclusion confirmed that microglial SIRT1 mediates UB's effects, positioning as a promising candidate for targeting neuroinflammatory pathways.

Language: Английский

Citations

0
Advances in the prevalence and treatment of depression for adolescents: a review DOI Creative Commons

Chunyu Yin,

Mengting Xu,

Zhiyuan Zong

et al.

Frontiers in Pharmacology, Journal Year: 2025, Volume and Issue: 16

Published: May 6, 2025

Background Depression is a psychological condition in adolescents caused by various factors. Many serious consequences can be associated with depression, such as irritability, emotional instability, and suicide. Meanwhile, the incidence of depression suicide among was also affected during pandemic COVID-19 2019. This phenomenon adolescent should drawn extensive concern community, which affects their physical mental health. Main body review describes epidemiology, high-risk factors, treatment depression. The onset probably attributable to preterm birth, growth environment, genetic. We identify that pandemic, initiated late 2019,affects Antidepressants psychotherapy are conventional treatments for depressive disorders. However, it controversial whether antidepressants effective safer psychotherapy, combination two could provide more benefit this population than alone. summarize some developed novel targets. Improving efficacy safety reduce rate primary goal clinical research. Existing modalities drugs not sufficient achieve demands, so new therapeutic targets will promising patients. Conclusion A variety factors contribute adolescents. Adolescent mainly treated non-pharmacological. guideline-recommended used if uncontrolled non-pharmacological, but adverse drug reactions suicidal ideation closely monitored.

Language: Английский

Citations

0
Sirtuin 1 underlies depression-related behaviors by modulating the serotonin system in the dorsal raphe nucleus in female mice DOI
Lihong Xu,

Yifan Cao,

Shasha Zhang

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111400 - 111400

Published: May 1, 2025

Language: Английский

Citations

0
Schisandrol B alleviates depression-like behavior in mice by regulating bile acid homeostasis in the brain-liver-gut axis via the pregnane X receptor DOI
Peng Wang, Hui Ouyang, Guofang Bi

et al.

Phytomedicine, Journal Year: 2024, Volume and Issue: 137, P. 156340 - 156340

Published: Dec. 27, 2024

Language: Английский

Citations

1
Epigenetic Regulation of Neural Activity in the Depressed Brain: The Two Faces of the Histone Deacetylase SIRT1 DOI
Angélica Torres‐Berrío

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(6), P. e7 - e9

Published: Aug. 19, 2024

Language: Английский

Citations

0
SIRT1: A Potential Therapeutic Target for Coronary Heart Disease Combined with Anxiety or Depression DOI
Hongbo Yu, Xinping Li, Bo Ning

et al.

Journal of drug targeting, Journal Year: 2024, Volume and Issue: 33(3), P. 328 - 340

Published: Oct. 29, 2024

Coronary heart disease (CHD) combined with anxiety or depression is increasingly receiving attention in the clinical field of cardiology, and exploring comorbidity pathological mechanisms cardiovascular psychological disorders a hot research topic for scholars this field. Current suggests that Silent Information Regulatory Factor 1 (SIRT1) may serve as potential biomarker mechanism treatment CHD depression. SIRT1 considered promising therapeutic target depression, ability to regulate inflammatory cytokine levels, alleviate oxidative stress damage, activate multiple signalling pathways, reduce platelet hyperresponsiveness, exert neuroprotective cardioprotective effects. In comprehensive review, we deeply studied structure, function, SIRT1, discussed its protective effects nervous system. The latest progress SIRT1's role was emphasised, including specific regulating response, alleviating stress, mediating various pathways. addition, article also summarises patients

Language: Английский

Citations

0