Random Mutagenesis as a Promising Tool for Microalgal Strain Improvement towards Industrial Production

Marine Drugs, Journal Year: 2022, Volume and Issue: 20(7), P. 440 - 440

Published: June 30, 2022

Microalgae have become a promising novel and sustainable feedstock for meeting the rising demand food feed. However, microalgae-based products are currently hindered by high production costs. One major reason this is that commonly cultivated wildtype strains do not possess robustness productivity required successful industrial production. Several strain improvement technologies been developed towards creating more stress tolerant productive strains. While classical methods of forward genetics extensively used to determine gene function randomly generated mutants, reverse has explored generate specific mutations target phenotypes. Site-directed mutagenesis can be accomplished employing different editing tools, which enable generation tailor-made genotypes. Nevertheless, strategies promoting selection mutants avoid introduction foreign genetic material. In paper, we review microalgal approaches their applications, with primary focus on random mutagenesis. Current challenges hampering improvement, selection, commercialization will discussed. The combination these high-throughput technologies, such as fluorescence-activated cell sorting, tools select most also

Language: Английский

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Microalgae biofuels: illuminating the path to a sustainable future amidst challenges and opportunities

Biotechnology for Biofuels and Bioproducts, Journal Year: 2024, Volume and Issue: 17(1)

Published: Jan. 23, 2024

Abstract The development of microalgal biofuels is significant importance in advancing the energy transition, alleviating food pressure, preserving natural environment, and addressing climate change. Numerous countries regions across globe have conducted extensive research strategic planning on bioenergy, investing funds manpower into this field. However, microalgae biofuel industry has faced a downturn due to constraints high costs. In past decade, with new strains, technologies, equipment, feasibility large-scale production should be re-evaluated. Here, we gathered results from decade regarding production, providing insights opportunities challenges by perspectives selection, modification, cultivation. review, suggest that highly adaptable are preferred choice for especially strains can utilize concentrations inorganic carbon sources possess stress resistance. use omics technologies genetic editing greatly enhanced lipid accumulation microalgae. associated risks constrained outdoor Therefore, relatively controllable cultivation method photobioreactors (PBRs) made it mainstream approach production. Moreover, adjusting performance parameters PBRs also enhance future, given relentless escalation demand sustainable sources, deemed pivotal constituent national planning, particularly case China. advancement synthetic biology helps reduce genetically modified (GM) enhances economic viability their Graphical

Language: Английский

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Integrated culture and harvest systems for improved microalgal biomass production and wastewater treatment

Bioresource Technology, Journal Year: 2023, Volume and Issue: 376, P. 128941 - 128941

Published: March 21, 2023

Language: Английский

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Applications of Microalgae in Foods, Pharma and Feeds and Their Use as Fertilizers and Biostimulants: Legislation and Regulatory Aspects for Consideration

Foods, Journal Year: 2023, Volume and Issue: 12(20), P. 3878 - 3878

Published: Oct. 23, 2023

Microalgae are a rich resource of lipids, proteins, carbohydrates and pigments with nutritional health benefits. They increasingly find use as ingredients in functional foods feeds well cosmetics agricultural products including biostimulants. One their distinct advantages is ability to grow on wastewaters other waste streams, they considered an environmentally friendly cheap method recover nutrients remove pollutants from the environment. However, there limits concerning applications if grown certain streams. Within, we collate overview existing algal current market scenarios for microalgal along relevant legislative requirements Europe United States. Microalgal compounds interest extraction processing methodologies summarized, benefits caveats microalgae cultivated various streams discussed.

Language: Английский

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Emerging prospects of microbial production of omega fatty acids: Recent updates

Bioresource Technology, Journal Year: 2022, Volume and Issue: 360, P. 127534 - 127534

Published: June 28, 2022

Language: Английский

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Recent advances in enhancing the production of long chain omega-3 fatty acids in microalgae

Critical Reviews in Food Science and Nutrition, Journal Year: 2023, Volume and Issue: 64(29), P. 10564 - 10582

Published: June 26, 2023

Omega-3 fatty acids have gained attention due to numerous health benefits. Eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) are long chain omega-3 produced from precursor ALA (α-linolenic acid) in humans but their rate of biosynthesis is low, therefore, these must be present diet or should taken as supplements. The commercial sources limited vegetable oils marine sources. rising concern about vegan source, fish aquaculture conservation heavy metal contamination has led the search for alternative source. Microalgae importance production high-value EPA DHA can thus serve a sustainable promising source acids. Although bottleneck lies optimization enhanced that involves strategies

Language: Английский

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Highly Valuable Fish Oil: Formation Process, Enrichment, Subsequent Utilization, and Storage of Eicosapentaenoic Acid Ethyl Esters

Molecules, Journal Year: 2023, Volume and Issue: 28(2), P. 672 - 672

Published: Jan. 9, 2023

In recent years, as the demand for precision nutrition is continuously increasing, scientific studies have shown that high-purity eicosapentaenoic acid ethyl ester (EPA-EE) functions more efficiently than mixed omega-3 polyunsaturated fatty preparations in diseases such hyperlipidemia, heart disease, major depression, and disease; therefore, market EPA-EE growing by day. this paper, we attempt to review from a whole-manufacturing-chain perspective. First, extraction, refining, ethanolysis processes (fish oil ethanol undergo transesterification) of are described, emphasizing potential green substitute technologies. Then, method EPA enrichment thoroughly detailed, pros cons different methods compared, current developments monomer production techniques addressed. Finally, summary advanced strategies dealing with low oxidative stability bioavailability presented. conclusion, understanding entire process will enable us govern each step macro perspective accomplish best use cost-effective environmentally friendly way.

Language: Английский

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A comprehensive review on microbial lipid production from wastes: research updates and tendencies

Environmental Science and Pollution Research, Journal Year: 2023, Volume and Issue: 30(33), P. 79654 - 79675

Published: June 16, 2023

Language: Английский

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Microalgae stress sensing through oxidative phosphorylation drives bioenergy potential: deciphering mechanisms and future opportunities

Journal of environmental chemical engineering, Journal Year: 2024, Volume and Issue: 12(6), P. 114266 - 114266

Published: Sept. 26, 2024

Language: Английский

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Paradigm of integrative OMICS of microbial technology towards biorefinery prospects

Biocatalysis and Agricultural Biotechnology, Journal Year: 2024, Volume and Issue: 58, P. 103226 - 103226

Published: May 11, 2024

Language: Английский

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