Langmuir,
Journal Year:
2024,
Volume and Issue:
unknown
Published: Dec. 6, 2024
Metal-organic
framework
(MOF)
derived
spherical
porous
carbon
(SPC)
has
potential
application
value
in
the
field
of
adsorption
and
sustained
release
nitroimidazole
drugs.
This
work
used
MIL-53(Fe)
as
a
precursor
prepared
3-aminophenol-formaldehyde
resin
containing
crystals
using
advanced
Stöber
method,
followed
by
successful
preparation
SPC
(MSPC)
with
structure
both
micropores
mesopores
through
high-temperature
carbonization.
The
effects
doping
amount
on
sphericity
particle
size
MSPC
were
investigated.
drug
uptake
capacity
performances
for
metronidazole
(MNZ)
ornidazole
(ONZ)
assessed
batch
tests,
along
an
investigation
into
impact
varying
pH
levels
performances.
experimental
findings
revealed
that
loading
MNZ
ONZ
onto
achieved
111
120
mg/g,
respectively,
time
up
to
24
h.
process
adhered
Langmuir
isotherm
model
conformed
pseudo-second-order
kinetics
model,
whereas
mechanism
was
consistent
Korsmeyer-Peppas
model.
Furthermore,
cytotoxicity
cyclic
experiments
indicated
exhibited
good
biocompatibility
stability.
Therefore,
this
study
provides
new
ideas
development
carriers.
