Factors Affecting Preparation of Molecularly Imprinted Polymer and Methods on Finding Template-Monomer Interaction as the Key of Selective Properties of the Materials

Molecules, Journal Year: 2021, Volume and Issue: 26(18), P. 5612 - 5612

Published: Sept. 16, 2021

Molecular imprinting is a technique for creating artificial recognition sites on polymer matrices that complement the template in terms of size, shape, and spatial arrangement functional groups. The main advantage Molecularly Imprinted Polymers (MIP) as use with molecular they have high selectivity affinity target molecules used molding process. components Polymer are template, monomer, cross-linker, solvent, initiator. Many things determine success Polymer, but component interaction between template-monomers most critical factors. This review will discuss how to find monomer before polymerization after choose suitable MIP development. Computer simulation, UV-Vis spectroscopy, Fourier Transform Infrared Spectroscopy (FTIR), Proton-Nuclear Magnetic Resonance (1H-NMR) generally type strength intermolecular pre-polymerization stage. In turn, Suspended State Saturation Transfer Difference High Resolution/Magic Angle Spinning (STD HR/MAS) NMR, Raman Spectroscopy, Surface-Enhanced Scattering (SERS) Fluorescence detect chemical polymerization. Hydrogen bonding becoming focus all methods this strongly contributes molecularly imprinted polymers (MIPs).

Language: Английский

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Molecularly imprinted polymer-based electrochemical sensors for food contaminants determination

TrAC Trends in Analytical Chemistry, Journal Year: 2022, Volume and Issue: 158, P. 116830 - 116830

Published: Nov. 17, 2022

The critical food safety assessment is one of the essences modern industry. major factors contributing to this include increased public awareness safe and surge in quantity variety pollutants because globalization, industrialization, population growth. With molecularly imprinted polymer (MIP) recognition units, electrochemical sensors have opted for analysis recent decades. MIP-based are versatile as they can be devised different contaminants. They offer simplicity terms sensor preparation measurement cost-efficiency. These sensors' affinity target analytes often high. In effect, number publications reporting MIP chemosensors quality monitoring applications has significantly increased. Therefore, present review highlights developments fabricating recognition-units-based their determining contaminants various drink matrices.

Language: Английский

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Biomimetic electrochemical sensors: New horizons and challenges in biosensing applications

Biosensors and Bioelectronics, Journal Year: 2021, Volume and Issue: 185, P. 113242 - 113242

Published: April 18, 2021

Language: Английский

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Electrochemical sensing system for the analysis of emerging contaminants in aquatic environment: A review

Chemosphere, Journal Year: 2022, Volume and Issue: 294, P. 133779 - 133779

Published: Jan. 31, 2022

Language: Английский

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Molecularly Imprinted Polymers for the Determination of Cancer Biomarkers

International Journal of Molecular Sciences, Journal Year: 2023, Volume and Issue: 24(4), P. 4105 - 4105

Published: Feb. 18, 2023

Biomarkers can provide critical information about cancer and many other diseases; therefore, developing analytical systems for recognising biomarkers is an essential direction in bioanalytical chemistry. Recently molecularly imprinted polymers (MIPs) have been applied to determine biomarkers. This article aims overview of MIPs used the detection biomarkers, namely: prostate (PSA), breast (CA15-3, HER-2), epithelial ovarian (CA-125), hepatocellular carcinoma (AFP), small molecule (5-HIAA neopterin). These may be found tumours, blood, urine, faeces, or body fluids tissues. The determination low concentrations these complex matrices technically challenging. overviewed studies MIP-based biosensors assess natural artificial samples such as serum, plasma, urine. Molecular imprinting technology sensor creation principles are outlined. Analytical signal methods nature chemical structure discussed. Based on reviewed biosensors, results compared, most suitable materials each biomarker

Language: Английский

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On-Demand, Reversible, Ultrasensitive Polymer Membrane Based on Molecular Imprinting Polymer

ACS Nano, Journal Year: 2023, Volume and Issue: 17(6), P. 5632 - 5643

Published: March 13, 2023

The development of in vivo, longitudinal, real-time monitoring devices is an essential step toward continuous, precision health monitoring. Molecularly imprinted polymers (MIPs) are popular sensor capture agents that more robust than antibodies and have been used for sensors, drug delivery, affinity separations, assays, solid-phase extraction. However, MIP sensors typically limited to one-time use due their high binding (>107 M–1) slow-release kinetics (<10–4 μM/sec). To overcome this challenge, current research has focused on stimuli-responsive MIPs (SR-MIPs), which undergo a conformational change induced by external stimuli reverse molecular binding, requiring additional chemicals or outside stimuli. Here, we demonstrate fully reversible based electrostatic repulsion. Once the target analyte bound within thin film electrode, small electrical potential successfully releases molecules, enabling repeated, accurate measurements. We electrostatically refreshed dopamine with 760 pM limit detection, linear response profile, accuracy even after 30 sensing–release cycles. These could repeatedly detect <1 nM released from PC-12 cells vitro, demonstrating they can longitudinally measure low concentrations complex biological environments without clogging. Our work provides simple effective strategy enhancing MIPs-based biosensors all charged molecules other sensing applications.

Language: Английский

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Editors’ Choice—Challenges and Opportunities for Developing Electrochemical Biosensors with Commercialization Potential in the Point-of-Care Diagnostics Market

ECS Sensors Plus, Journal Year: 2024, Volume and Issue: 3(1), P. 011601 - 011601

Published: March 1, 2024

There is a plethora of electrochemical biosensors developed for ultrasensitive detection clinically relevant biomarkers. However, many these systems lose their performance in heterogeneous clinical samples and are too complex to be operated by end users at the point-of-care (POC), prohibiting commercial success. Integration with sample processing technology addresses both challenges; however, it adds manufacturing complexity overall cost systems. Herein, we review different components biosensor avenues creating fully integrated In context integration, focus on discussing trade-offs between sensing performance, cost, scalable guide readers toward designing new commercialization potential.

Language: Английский

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Electrochemical sensing mechanisms of neonicotinoid pesticides and recent progress in utilizing functional materials for electrochemical detection platforms

Talanta, Journal Year: 2024, Volume and Issue: 273, P. 125937 - 125937

Published: March 16, 2024

Language: Английский

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From Challenge to Opportunity: Revolutionizing the Monitoring of Emerging Contaminants in Water with Advanced Sensors

Water Research, Journal Year: 2024, Volume and Issue: 265, P. 122297 - 122297

Published: Aug. 23, 2024

Language: Английский

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Furoic acid-doped-over-oxidized poly (3, 4-ethylenedioxythiophene)-based electrochemical sensor for selective, sensitive and concurrent quantification of paracetamol, codeine phosphate and caffeine in pharmaceutical formulation

Journal of materials research/Pratt's guide to venture capital sources, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 17, 2025

Language: Английский

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