Microfluidic Brain‐on‐a‐Chip: From Key Technology to System Integration and Application

Small, Journal Year: 2023, Volume and Issue: 19(52)

Published: Aug. 31, 2023

Abstract As an ideal in vitro model, brain‐on‐chip (BoC) is important tool to comprehensively elucidate brain characteristics. However, the model for definition scope of BoC has not been universally recognized. In this review, divided into cells‐on‐a‐ chip, slices‐on‐a‐chip, and organoids‐on‐a‐chip according type culture on chip. Although these three microfluidic BoCs are constructed different ways, they all use chips as carrier tools. This method can better meet needs maintaining high activity a chip long time. Moreover, successfully integrated cell biology, biological material platform technology microenvironment manufacturing technology, online detection so on, enabling present structural diversity compatibility experimental expand applications. Here, relevant core technologies, challenges, future development trends summarized.

Language: Английский

Biohybrid tongue based on hypothalamic neuronal network-on-a-chip for real-time blood glucose sensing and assessment

Biosensors and Bioelectronics, Journal Year: 2023, Volume and Issue: 244, P. 115784 - 115784

Published: Oct. 24, 2023

Language: Английский

β-amyloid’s neurotoxic mechanisms as defined by in vitro microelectrode arrays: a review

Pharmacological Research, Journal Year: 2024, Volume and Issue: 209, P. 107436 - 107436

Published: Oct. 4, 2024

Language: Английский