Biosensors,
Journal Year:
2023,
Volume and Issue:
13(9), P. 883 - 883
Published: Sept. 12, 2023
Mitochondrial
hypochlorite
(ClO-)
plays
important
and
often
contradictory
roles
in
maintaining
the
redox
balance
of
mitochondria.
Abnormal
ClO-
levels
can
induce
mitochondrial
inactivation
further
cause
cell
apoptosis.
Herein,
we
have
developed
an
anthracene
carboxyimide-based
fluorescent
probe
mito-ACS
for
imaging
living
cells.
This
exhibits
some
distinctive
features
as
excellent
resistance
to
photobleaching,
high
selectivity
sensitivity,
well
good
water
solubility.
Mito-ACS
showed
a
noticeable
fluorescence
response
toward
with
fast
(within
6
s)
low
detection
limit
(23
nM).
Moreover,
introduction
triphenylphosphonium
makes
soluble
selectively
localizes
Furthermore,
was
successfully
applied
image
mitochondria
cells
toxicity.
Remarkably.
less
used
fluorophore
carboxyimide
exhibiting
photostability
desirable
optical
properties
provides
promising
application
prospect
biological
systems.
Advanced Materials,
Journal Year:
2023,
Volume and Issue:
unknown
Published: Sept. 4, 2023
Neoadjuvant
and
adjuvant
therapies
have
made
significant
progress
in
cancer
treatment.
However,
tumor
therapy
still
faces
challenges
due
to
the
intrinsic
heterogeneity
of
cancer,
genomic
instability,
formation
an
immunosuppressive
microenvironment.
Functional
materials
possess
unique
biological
properties
such
as
long
circulation
times,
tumor-specific
targeting,
immunomodulation.
The
combination
functional
with
natural
substances
nanotechnology
has
led
development
smart
biomaterials
multiple
functions,
high
biocompatibilities,
negligible
immunogenicities,
which
can
be
used
for
precise
Recently,
subcellular
structure-targeting
received
particular
attention
various
biomedical
applications
including
diagnosis,
sensing,
imaging
tumors
drug
delivery.
Subcellular
organelle-targeting
precisely
accumulate
therapeutic
agents
organelles,
considerably
reduce
threshold
dosages
agents,
minimize
drug-related
side
effects.
This
review
provides
a
systematic
comprehensive
overview
research
organelle-targeted
based
on
nanomaterials.
Moreover,
it
explains
prospects
precision
oncology.
will
serve
excellent
cutting-edge
guide
researchers
field
therapy.
Nature Communications,
Journal Year:
2024,
Volume and Issue:
15(1)
Published: Oct. 31, 2024
Lipid
droplets
(LDs)
feature
a
unique
monolayer
lipid
membrane
that
has
not
been
extensively
studied
due
to
the
lack
of
suitable
molecular
probes
are
able
distinguish
this
from
LD
core.
In
work,
we
present
three-pronged
probe
design
strategy
combines
lipophilicity-based
organelle
targeting
with
microenvironment-dependent
activation
and
an
labeling
pro-probe
called
LDM.
Upon
by
HClO/ClO−
microenvironment
surrounds
LDs,
LDM
releases
LDM-OH
binds
proteins
thus
enabling
visualization
ring-like
membrane.
By
utilizing
LDM,
identify
dynamic
mechanism
contacts
their
protein
accumulation
parameters.
Taken
together,
represents
first
for
imaging
membranes
in
live
cells
best
our
knowledge,
attractive
tool
further
investigations
into
specific
regulatory
mechanisms
LD-related
metabolism
diseases
drug
screening.
play
essential
roles
many
biological
processes,
but
LDs
probes.
Here,
authors
report
labelling
which,
upon
undergoes
color
change
proteins.
Analytical Chemistry,
Journal Year:
2024,
Volume and Issue:
96(5), P. 2264 - 2272
Published: Jan. 24, 2024
Lipid
metabolism
diseases
have
become
a
tremendous
risk
worldwide,
along
with
the
development
of
productivity
and
particular
attention
to
public
health.
It
has
been
an
urgent
necessity
exploit
reliable
imaging
strategies
for
lipids
thus
monitor
fatty
liver
diseases.
Herein,
by
converting
NIR-I
signal
NIR-II
IR1061
monitoring
lipid,
in
vivo
disease
was
promoted
on
contrast
visual
effect.
The
main
advantages
promotion
this
work
included
long
emission
wavelength,
rapid
response,
high
signal-background-ratio
(SBR)
value.
After
promoting
signal,
achieved
higher
SBR
value
exhibited
dose-dependent
fluorescence
intensity
at
1100
nm
increase
EtOH
proportion
as
well
steady
selective
optical
responses
toward
liposomes.
further
applied
lipid
In
spite
differences
body
weight
gain
TC
level
between
healthy
mice
two
models,
high-resolution
region
status.
This
might
be
informatic
clinical
diagnosis
therapeutical
treatments
