Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 267, P. 116805 - 116805
Published: Sept. 20, 2024
Language: Английский
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 271, P. 117067 - 117067
Published: Dec. 14, 2024
Language: Английский
Citations
2
Proteins Structure Function and Bioinformatics, Journal Year: 2023, Volume and Issue: unknown
Published: Aug. 2, 2023
Abstract Before the controversial approval of humanized monoclonal antibody lecanemab, which binds to soluble amyloid‐β protofibrils, all treatments available earlier, for Alzheimer's disease (AD) were symptomatic. The researchers are still struggling find a breakthrough in AD therapeutic medicine, is partially attributable lack understanding structural information associated with intrinsically disordered proteins and amyloids. One major challenges this area research understand diversity under vitro conditions. Therefore, review, we have summarized applications biophysical methods, aimed shed some light on heterogeneity, pathogenicity, structures mechanisms protein aggregates proteinopathies including AD. This review will also rationalize strategies modulating disease‐relevant pathogenic entities by small molecules using biology approaches characterization. We highlighted tools techniques simulate vivo conditions native cytotoxic tau/amyloids assemblies, urge new chemical replicate assemblies similar those conditions, addition designing novel potential drugs.
Language: Английский
Citations
5
Journal of Materials Chemistry B, Journal Year: 2023, Volume and Issue: 11(46), P. 11082 - 11093
Published: Jan. 1, 2023
The development of a theranostic platform that integrates both diagnostic and therapeutic capabilities is in great need for precise personalized medicine. Here, we present novel nanoplatform (AuNS@CS-hpDNA) formulated by chitosan functionalized gold nanostar composites further complexed with fluorescent hairpin DNA (hpDNA) probes tumor-related miRNA imaging photothermal therapy (PTT). optimized AuNS@CS-hpDNA mediated efficient hpDNA probe loading intracellular delivery. Subsequently, the cytosol transfer enabled specific hybridization using targeted miRNA, which triggered recovery fluorescence detection biomarker miR21 living cells realized distinguishing cancer cell line MCF-7 normal cells. Meanwhile, exhibited excellent conversion properties, induced killing under laser irradiation. Thus, developed could simultaneously realize accurately initiate PTT, represents promising strategy therapy.
Language: Английский
Citations
5
Luminescence, Journal Year: 2024, Volume and Issue: 39(1)
Published: Jan. 1, 2024
Abstract The coronavirus disease‐2019 pandemic reflects the underdevelopment of point‐of‐care diagnostic technology. Nuclei acid (NA) detection is “gold standard” method for early diagnosis B.1.1.529 (Omicron) variant severe acute respiratory syndrome‐coronavirus disease‐2. Polymerase chain reaction main NA but requires considerable manpower and sample processing taking ≥ 3 h. To simplify operation processes reduce time, exonuclease III (Exo III)‐aided MoS 2 /AIE nanoprobes were developed rapid sensitive oligonucleotides Omicron. Molybdenum disulfide (MoS ) nanosheets with excellent optical absorbance distinguishable affinity to single‐strand duplex DNAs applied as quenchers, aggregation‐induced emission (AIE) molecules high luminous efficiency designed donor in fluorescence resonance energy transfer‐based nanoprobes. Exo catalytic capability was used signal amplification increase sensitivity detection. composite detected mutated nucleocapsid (N)‐gene spike (S)‐gene Omicron within 40 min a limit 4.7 pM, showed great potential application community medicine.
Language: Английский
Citations
1
Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 267, P. 116805 - 116805
Published: Sept. 20, 2024
Language: Английский
Citations
1