Domain‐Limited Sub‐Nanometer Co Nanoclusters in Defective Nitrogen Doped Carbon Structures for Non‐Invasive Drug Monitoring

Small, Journal Year: 2023, Volume and Issue: 20(16)

Published: Nov. 27, 2023

Abstract In this work, sub‐nanometer Co clusters anchored on porous nitrogen‐doped carbon (C─N─Co NCs) are successfully prepared by high‐temperature annealing and pre‐fabricated template strategies for non‐invasive sensing of clozapine (CLZ) as an efficient substrate adsorption electrocatalyst. The introduction sub‐nanoclusters (Co provides enhanced electrochemical performance better potential compared to structures. Combined with ab initio calculations, it is found that the favorable CLZ catalytic C─N─Co NCs mainly attributed possessing a more stable structure lower conversion barriers oxidized state CLZ. An sensor detection conceptualized wide operating range high sensitivity, monitoring capabilities validated in variety body fluid environments. Based developed system, correlation between blood saliva accuracy investigated gold standard method rat model drug administration, paving way monitoring. This work new insights into development electrocatalysts enable therapy administration personalized healthcare systems.

Language: Английский

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Recent advances in nano biosensors: An overview

Measurement, Journal Year: 2024, Volume and Issue: 236, P. 115073 - 115073

Published: June 6, 2024

Language: Английский

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Structural bioelectrochemistry of direct electron transfer-type multimeric dehydrogenases: Basic principle and rational strategies

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108973 - 108973

Published: March 1, 2025

Language: Английский

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Multisensors based on electrolyte-gated organic field-effect transistors (EGOFETs) with aptamers as recognition elements: current state of research

Russian Chemical Reviews, Journal Year: 2024, Volume and Issue: 93(4), P. RCR5116 - RCR5116

Published: April 1, 2024

The review gives a systematic account of published data devoted to multisensor technologies for manufacturing effective miniature devices capable simultaneous accurate determination several analytes and/or characteristics biological fluids. use electrolyte-gated field-effect transistors as biosensing platform is considered in detail. based on these demonstrate record-low limits detection and are easy mass production. combination with aptamers specifically binding various forms the grounds innovations early medical diagnosis (label-free biomarker detection). most successful examples using presented, prospects recognition element demonstrated.<br>Bibliography — 154 references.

Language: Английский

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Tailoring Water-Based Graphite Conductive Ink Formulation for Enzyme Stencil-Printing: Experimental Design to Enhance Wearable Biosensor Performance

Chemistry of Materials, Journal Year: 2023, Volume and Issue: 36(1), P. 358 - 370

Published: Dec. 27, 2023

Herein, we report for the first time an experimental design-based approach to develop water-based graphite conductive ink containing enzymes and redox mediators obtain fully printed wearable biosensors lactate glucose monitoring. The design encompasses both electrochemical parameters, such as electroactive area electron transfer rate constant, rheological including elastic (G′) viscous (G″) moduli where G″/G′ is expressed tanδ. Notably, electrodes exhibited AEA of 3.95 ± 0.31 cm2 a roughness factor, ρ, 43.8, which 50 times higher than those commercially available screen-printed electrodes. Furthermore, oxidase are integrated within enzyme-based inks: enzyme-ink (E-INK), detect lactate, enzyme mediator-ink (EM-INK), glucose. resulting demonstrated high sensitivity low limit detection 3.3 μA mM–1 0.3 0.1 μM (ferricyanide mediator), 4.3 3 1 μM, E-INK EM-INK, respectively. also excellent selectivity, maintaining their storage stability, with approximately 80–90% initial signal retained after 90 days. Overall, this promising system holds potential be utilized flexible biosensor. Its use biocompatible inks makes it suitable applications in sports medicine remote clinical care.

Language: Английский

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Enhanced Electron Transfer Efficiency of Fructose Dehydrogenase onto Roll-to-Roll Thermal Stamped Laser-Patterned Reduced Graphene Oxide Films

ACS Applied Materials & Interfaces, Journal Year: 2024, Volume and Issue: 16(17), P. 22443 - 22454

Published: April 17, 2024

Herein, a strategy to stamp laser-produced reduced graphene oxide (rGO) onto flexible polymers using only office-grade tools, namely, roll-to-roll thermal stamping, is proposed, proving for the first time its effectiveness direct bioelectrocatalysis. This straightforward, scalable, and low-cost approach allows us overcome limits of integration laser-induced rGO-films in bioanalytical devices. Laser-produced rGO has been thermally stamped (TS) different polymeric substrates (PET, PVC, EVA) simple roll-laminator; obtained TS-rGO films have compared with native (untransferred) via morphochemical electrochemical characterization. Particularly, electron transfer (DET) reaction between fructose dehydrogenase (FDH) transducers investigated, respect influence amount enzyme on catalytic process. Remarkable differences observed among transducers; PET proved be elective substrate support rGO, allowing preservation features material returning capacitive current. Noteworthily, TS-rGOs ensure superior electrocatalysis very low FDH units (15 mU). Eventually, TS-rGO-based third-generation complete enzymatic biosensors were fabricated benchtop technologies. TS-rGOPET exhibited performances sensitive (0.0289 μA cm-2 μM-1) reproducible (RSD = 3%, n 3) d-fructose determination at nanomolar level (LOD 0.2 μM). exploitability as point-of-need device was monitoring during banana (Musa acuminata) postharvest ripening, accurate (recoveries 110-90%; relative error -13/+1%) ≤ 7%; data.

Language: Английский

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Self-powered wearable biosensor based on stencil-printed carbon nanotube electrodes for ethanol detection in sweat

Analytical and Bioanalytical Chemistry, Journal Year: 2024, Volume and Issue: 416(24), P. 5303 - 5316

Published: Aug. 12, 2024

Herein we introduce a novel water-based graphite ink modified with multiwalled carbon nanotubes, designed for the development of first wearable self-powered biosensor enabling alcohol abuse detection through sweat analysis. The stencil-printed (SPG) electrodes, printed onto flexible substrate, were by casting nanotubes (MWCNTs), electrodepositing polymethylene blue (pMB) at anode to serve as catalyst nicotinamide adenine dinucleotide (NADH) oxidation, and hemin cathode selective H

Language: Английский

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High voltage flexible glucose/O₂ fully printed hydrogel-based enzymatic fuel cell

Journal of Physics D Applied Physics, Journal Year: 2023, Volume and Issue: 57(13), P. 135503 - 135503

Published: Dec. 22, 2023

Abstract Herein we report on a novel enzymatic fuel cell (EFC) based stencil printed electrodes modified with pyrrolo quinoline quinone glucose dehydrogenase and bilirubin oxidase, which are assembled by considering two different configurations: (i) normal assembling in liquid electrolyte (ii) six EFCs connected series, each one comprising both bioanode biocathode, coupled through hydrogel-based stack-like mode similar to Voltaic pile. After deep characterization, they according the first configuration obtaining an open circuit voltage (OCV) of 0.562 ± 0.002 V. Moreover, EFC performance substantially improved using second (six series) OCV 2.36 0.22 V maximum power output 22.9 0.9 μ W at 1.95 (operating 10 mM D-glucose). This innovative approach represents proof-of-concept towards development renewable sources could serve as critical step powering implantable bioelectronics, such pacemakers.

Language: Английский

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Fire up Biosensor Technology to Assess the Vitality of Trees after Wildfires

Biosensors, Journal Year: 2024, Volume and Issue: 14(8), P. 373 - 373

Published: July 31, 2024

The development of tools to quickly identify the fate damaged trees after a stress event such as wildfire is great importance. In this context, an innovative approach assess irreversible physiological damage in could help support planning management decisions for disturbed sites restore biodiversity, protect environment and understand adaptations ecosystem functionality. vitality can be estimated by several indicators, cambium activity amount starch soluble sugars, while accumulation ethanol cambial cells phloem considered alarm sign cell death. However, their determination requires time-consuming laboratory protocols, making impractical field. Biosensors hold considerable promise substantially advancing general objective review define system quantifying plant forest areas exposed fire. This describes recent electrochemical biosensors that detect molecules, focusing on glucose, fructose, indicators tree vitality.

Language: Английский

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Disposable electrochemical aptasensor with mesoporous carbon spheres modified screen-printed dual-working electrodes for Pb2+ and Hg2+ detection

Sensors and Actuators B Chemical, Journal Year: 2024, Volume and Issue: 422, P. 136558 - 136558

Published: Aug. 30, 2024

Language: Английский

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