Nanomaterial-mediated self-calibrating biosensors for ultra-precise detection of food hazards: Recent advances and new horizons

Coordination Chemistry Reviews, Journal Year: 2024, Volume and Issue: 522, P. 216204 - 216204

Published: Sept. 10, 2024

Language: Английский

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Enhancing 3D DNA Walker-Induced CRISPR/Cas12a Technology for Highly Sensitive Detection of ExomicroRNA Associated with Osteoporosis

ACS Sensors, Journal Year: 2024, Volume and Issue: 9(3), P. 1438 - 1446

Published: March 7, 2024

Exosomal microRNAs (exomiRNAs) have emerged as promising biomarkers for the early clinical diagnosis of osteoporosis. However, their limited abundance and short length in peripheral blood present significant challenges accurate detection exomiRNAs. Herein, we designed implemented an efficacious fluorescence-based biosensor highly sensitive exomiRNA associated with osteoporosis, leveraging enhancing 3D DNA walker-induced CRISPR/Cas12a technology. The engineered walker is capable efficiently transforming target into amplifying strands, thereby sensitivity developed biosensor. Concurrently, liberated strands serve activators to trigger Cas12a trans-cleavage activity, culminating a significantly amplified fluorescent signal exomiRNA-214. Under optimal conditions, devised technology demonstrated capacity detect exomiRNA-214 at concentrations low 20.42 fM, encompassing wide linear range extending from 50.0 fM 10.0 nM. Moreover, could accurately differentiate between healthy individuals osteoporosis patients via exomiRNA-214, which was agreement RT-qPCR results. As such, this biosensing offers promise valuable tool

Language: Английский

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Ti3C2Tx/Au NPs/PPy ternary heterostructure-based intra-capacitive self-powered sensor for DEHP detection

Journal of Hazardous Materials, Journal Year: 2025, Volume and Issue: 488, P. 137311 - 137311

Published: Jan. 22, 2025

Language: Английский

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Graphdiyne-based nanomaterials: Synthesis, properties, and biomedical applications

ChemPhysMater, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 1, 2025

Language: Английский

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A dual-mode nanoplatform based on Cu2O@Au-Pt nanoenzyme and CHA-HCR DNA framework circuit for sensitive detection of CD122 and CD17

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 142740 - 142740

Published: April 1, 2025

Language: Английский

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Integrated OPECT and Smartphone Colorimetry Dual‐Mode Detection of Okadaic Acid Based on Ce‐MOF Modified MXene@SnO₂ Z‐Scheme Heterostructure

Advanced Functional Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Sept. 20, 2024

Abstract The organic photoelectrochemical transistor (OPECT) biosensing relies solely on a singular signal readout inherently, which restrains the precision and dependability nestled within pertinent biological measurements. Herein, high‐precision magnetic assisted OPECT smartphone colorimetric (SCL) dual‐mode platform is first established for detecting harmful algal toxin okadaic acid (OA) by biocatalytic reaction. MXene@SnO 2 ‐Ce‐MOF (MXSnO/Ce‐MOF) Z‐scheme heterojunctions with abundant oxygen vacancies are prepared as photoactive materials. Initially, in presence of OA, coupling trigger DNA (tDNA) to beads (MBs) via anchor (aDNA) released through interaction target analyte aptamer. Subsequently, carried tDNA triggers HCR between two hairpin sequences, producing long double helix chains capture glucose oxidase (GOx). obtained GOx supernatant catalyzes produce H O , can oxidize Ce‐MOF, leading alteration electrode color significant decrease overall photocurrent MXSnO/Ce‐MOF. Crucially, novel OPECT‐SCL biosensor exhibits excellent sensitivity precision, boasting detection thresholds low 42.9 p M 1.2 n respectively, accomplishes automated OA real samples. proposed dual‐signal measurement model constitutes sensitive, portable, precise quantification marine toxins.

Language: Английский

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Designing a Simple Electrochemical Genosensor for the Detection of Urinary PCA3, a Prostate Cancer Biomarker

Micromachines, Journal Year: 2024, Volume and Issue: 15(5), P. 602 - 602

Published: April 29, 2024

This study investigates the feasibility of a simple electrochemical detection Prostate Cancer Antigen 3 (PCA3) fragments extracted from patients’ urine, using thiolated single-strand DNA probe immobilized on gold surface without redox probe. To enhance PCA3 recognition process, we conducted comparative analysis hybridization location two probes: Probe 1 targets first 40 bases, while 2 fragment bases 47 to 86. Hybridization with followed, square wave voltammetry. The limit designed genosenors were order (2.2 ng/mL), and (1.6 ng/mL) for Probes 2, respectively, subsequent sensitivities (0.09 ± 0.01) µA−1 · µg−1 mL (0.10 mL. Specificity tests then sensor functionalized as it presents better analytical performances. results indicate that can clearly discriminate complementary target non-complementary one. A further modeling calibration curves Power Law/Hill model indicates dissociation constant increases by one magnitude, confirming ability perfectly ones.

Language: Английский

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Enhanced luminol electrochemiluminescence biosensing system based on highly dispersed bimetallic nanozyme coreaction accelerator and 3D DNA walker signal amplifier

Biosensors and Bioelectronics, Journal Year: 2024, Volume and Issue: 263, P. 116574 - 116574

Published: July 14, 2024

Language: Английский

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Graphdiyne-based biomaterials for biosensor and imaging applications

Elsevier eBooks, Journal Year: 2025, Volume and Issue: unknown, P. 533 - 568

Published: Jan. 1, 2025

Language: Английский

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Advances of functional graphdiyne in separation and detection

Talanta, Journal Year: 2025, Volume and Issue: 287, P. 127673 - 127673

Published: Jan. 30, 2025

Language: Английский

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