MX/MWCNTs composite material aids new strategy for HBV-DNA electrochemical biosensor: achieving multi-level signal amplification and unlabeled detection

Advanced Composites and Hybrid Materials, Journal Year: 2025, Volume and Issue: 8(1)

Published: Jan. 17, 2025

Hepatitis B virus DNA (HBV-DNA) serves as a crucial biomarker for the detection of hepatitis virus, with variations in its concentration blood samples providing vital insights into patient infection and recovery status. We have developed an electrochemical biosensor tailored HBV-DNA detection, exhibiting high sensitivity, specificity, broad range. The utilizes composite material composed MXene multiwalled carbon nanotubes (MX/MWCNTs), prepared through hand-shaking self-assembly technique, to modify glassy electrode (GCE) serve signal receivers. A meticulously designed padlock probe specifically recognizes forms double-stranded structure, which is subsequently degraded by exonuclease III. resulting sequence then hybridizes PolyT-primer create template, triggering rolling circle amplification releasing substantial amount pyrophosphate initial level amplification. Subsequently, induces release methylene blue (MB) from MB@ZIF-90 composite, achieving second released MB adsorbed MX/MWNCNTs-modified GCE, possesses cationic dye adsorption capabilities large specific surface area, generating completing third This offers range spanning 1.0 pM × 106 pM, remarkable limit low 0.5 (3σ/S), capable distinguishing base mismatches. Furthermore, it has demonstrated excellent specificity performance serum testing. this demonstrates significant potential clinical application, ultimate goal improving diagnosis management B.

Language: Английский

---

Wearable MOF Biosensors: A New Frontier in Real-Time Health Monitoring

TrAC Trends in Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 118156 - 118156

Published: Jan. 1, 2025

Language: Английский

---

“Off-on-off”-based metal-organic framework fluorescent sensor for adenosine triphosphate detection and tumor microenvironment-triggered drug release

Analytica Chimica Acta, Journal Year: 2025, Volume and Issue: 1345, P. 343741 - 343741

Published: Jan. 29, 2025

Language: Английский

---

Near-Infrared-II Fluorescent Probes for Analytical Applications: From In Vitro Detection to In Vivo Imaging Monitoring

Accounts of Chemical Research, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 5, 2025

ConspectusBiomarkers play a vital role in the regulation of life processes, especially predicting occurrence and development diseases. For early diagnosis precise treatment diseases, it has become necessary significant to detect biomarkers with sensitivity, accuracy, simplicity, convenience, even visualization. Fluorescent-probe-based techniques have been recognized as one most powerful tools for sensitive detection real time imaging biological samples. However, traditional optical probes, mainly including visible probes (400–700 nm) near-infrared I (NIR-I, 700–900 suffer from low poor resolution, strong absorption scattering, high background fluorescence, which hinder effective monitoring biomarkers.Fortunately, past decade witnessed remarkable evolution application fields II (NIR-II, 900–1700 driven by its exceptional characteristics advancement technologies. Leveraging superior penetration capabilities, negligible autofluorescence, extended fluorescence emission wavelengths, NIR-II fluorescent significantly enhance signal-to-noise ratio (SNR) vitro (IVD) temporal resolution vivo imaging. Our team committed design strategy, controlled synthesis, luminous mechanisms, biomedical applications probes. In this Account, we present representative works recent years our group field analytical applications, ranging different various also will further provide general overview First, are fully summarized, tumor marker detection, virus bacteria analysis, cell testing, small-molecule sensing. Second, adequately discussed, ROS gas monitoring, pH sensing, receptor some serious Finally, outline advantages discuss detail challenges well their future development. There is reasonable prospect that technology based on exhibit great potential research clinical disease diagnosis. We hope Account can expand reach into an broader spectrum fields, enhancing impact scientific discovery medical practice.

Language: Английский

---

Nanotechnology in Plant Nanobionics: Mechanisms, Applications, and Future Perspectives

Advanced Biology, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 12, 2025

Abstract Plants are vital to ecosystems and human survival, possessing intricate internal inter‐plant signaling networks that allow them adapt quickly changing environments maintain ecological balance. The integration of engineered nanomaterials (ENMs) with plant systems has led the emergence nanobionics, a field holds potential enhance capabilities significantly. This may result in improved photosynthesis, increased nutrient uptake, accelerated growth development. treated ENMs can be stress mitigators, pollutant detectors, environmental sensors, even light emitters. review explores recent advancements focusing on nanoparticle (NP) synthesis, adhesion, transport, fate, application enhancing physiological functioning, mitigation, health monitoring, energy production, sensing, overall productivity. Potential research directions challenges nanobionics highlighted, how material optimization innovation propelling smart agriculture, pollution remediation, energy/biomass production discussed.

Language: Английский

---

An electrochemical biosensor using AuNPs-Ti3C2Tx and ARGET ATRP reactions as signal amplification strategies for ultra-sensitive detection of HER2 protein

Bioelectrochemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108970 - 108970

Published: March 1, 2025

Language: Английский

---

Cadmium MOF-Based Varied {Cd₂} Clusters as Multifunctional Fluorescence Sensors to Detect Fe³⁺, Cr₂O₇^2–, TNP, and NFT

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: March 19, 2025

Metal-organic frameworks (MOFs) have been widely used in the field of fluorescence sensing due to their highly ordered spatial structures, large porosity, and uniform pore sizes. Here, two new Cd- MOFs (JLJU-2 JLJU-3), based on ligand 4-(1H-1,2,4-triazol-1-yl)phenyl-4,2':6',4"-terpyridine (L) carboxylate ligands, were synthesized by solvothermal method. JLJU-2 JLJU-3 characterized single-crystal X-ray diffraction, powder infrared spectroscopy, UV-visible thermogravimetric analysis. Respectively, exhibit 2D 3D structures using L 2-aminoterephthalic acid (2-ATA)/nitroterephthalic (NTPA), adopted with different coordination modes. Furthermore, porous crystal enable them be well-suited for applications sensing, which can detect Fe3+, Cr2O72-, TNP, NFT high selectivity sensitivity. This work provides useful information a versatile platform detection environmental contaminants.

Language: Английский

---

Recent Advances in Fluorescent Probe for Detecting Biorelevant Analytes during Stress in Plants

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: April 28, 2025

Plants are constantly exposed to various stressors that can severely hinder their growth and threaten agricultural productivity. Recent advancements in plant imaging using fluorescent probes have opened new avenues for exploring the intricate processes involved stress perception signaling. This review represents comprehensive effort consolidate recent advances probe technologies, encompassing small-molecule probes, nanoprobes, genetically encoded indicators, as revolutionary tools deciphering stress-induced physiological dynamics. We present a classification of designed detecting key biomolecules responses, including reactive species, phytohormones, enzymes, other signaling molecules. By critically evaluating design principles, practical applications, distinct advantages over conventional analytical methods, we aim empower scientists unraveling spatiotemporal regulation networks. Finally, propose strategic directions overcome current technical bottlenecks maximize potential fluorescence-based sensing advancing sustainable agriculture.

Language: Английский

---

Light-emitting probes for in situ sensing of plant information

Trends in Plant Science, Journal Year: 2024, Volume and Issue: unknown

Published: July 1, 2024

Language: Английский

---

Hydrodynamic Fluidic Pump Empowered Sensitive Recognition and Active Transport of Hydrogen Peroxide in 1D Channels

Advanced Science, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 11, 2024

Through synthetic chemistry, the development of molecular devices for precise selective recognition and active transport small molecules stands as one most ambitious objectives in extensive medical, environmental, biological applications. The periodical channels metal-organic frameworks (MOFs) with excellent chemical affinity offer vast regulatory space reaching this goal. Herein, by post-modifying fluorescent probes ionic liquid into Zr-MOFs (NU-1000), a donor-acceptor (D-A) system within 1D is created to construct hydrodynamic fluidic pump abundant channels. Irradiation light serves initiate direct fluid motion, expediting H

Language: Английский

---