Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility DOI Creative Commons
Julieta Gomez‐Frittelli, Gabrielle Devienne, Lee Edward Travis

et al.

eLife, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility digestion. Neuronal subtypes ENS have been distinguished by their electrophysiological properties, morphology, expression characteristic markers, notably neurotransmitters neuropeptides. Here we investigated synaptic cell adhesion molecules as novel type markers ENS. Our work identifies two Type II classic cadherins, Cdh6 Cdh8, specific to mouse colon. We show that Cdh6+ demonstrate all other distinguishing classifications including marker Calcb Nmu , Dogiel morphology AH-type electrophysiology I H current. Optogenetic activation distal colon evokes retrograde colonic motor complexes (CMCs), while pharmacologic blockade rhythmicity-associated current disrupts spontaneous generation CMCs. These findings provide first demonstration selective single neurochemical functional class neurons, critical for

Language: Английский

Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility DOI Open Access
Julieta Gomez‐Frittelli, Gabrielle Devienne, Lee Edward Travis

et al.

Published: Nov. 21, 2024

Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility digestion. Neuronal subtypes ENS have been distinguished by their electrophysiological properties, morphology, expression characteristic markers, notably neurotransmitters neuropeptides. Here we investigated synaptic cell adhesion molecules as novel type markers ENS. Our work identifies two Type II classic cadherins, Cdh6 Cdh8, specific to mouse colon. We show that Cdh6+ demonstrate all other distinguishing classifications including marker Calcb Nmu , Dogiel morphology AH-type electrophysiology I H current. Optogenetic activation distal colon evokes retrograde colonic motor complexes (CMCs), while pharmacologic blockade rhythmicity-associated current disrupts spontaneous generation CMCs. These findings provide first demonstration selective single neurochemical functional class neurons, critical for

Language: Английский

Citations

0
Synaptic cell adhesion molecule Cdh6 identifies a class of sensory neurons with novel functions in colonic motility DOI Creative Commons
Julieta Gomez‐Frittelli, Gabrielle Devienne, Lee Edward Travis

et al.

eLife, Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 21, 2024

Intrinsic sensory neurons are an essential part of the enteric nervous system (ENS) and play a crucial role in gastrointestinal tract motility digestion. Neuronal subtypes ENS have been distinguished by their electrophysiological properties, morphology, expression characteristic markers, notably neurotransmitters neuropeptides. Here we investigated synaptic cell adhesion molecules as novel type markers ENS. Our work identifies two Type II classic cadherins, Cdh6 Cdh8, specific to mouse colon. We show that Cdh6+ demonstrate all other distinguishing classifications including marker Calcb Nmu , Dogiel morphology AH-type electrophysiology I H current. Optogenetic activation distal colon evokes retrograde colonic motor complexes (CMCs), while pharmacologic blockade rhythmicity-associated current disrupts spontaneous generation CMCs. These findings provide first demonstration selective single neurochemical functional class neurons, critical for

Language: Английский

Citations

0