Electrochemical Biosensors for the Detection of Exosomal microRNA Biomarkers for Early Diagnosis of Neurodegenerative Diseases

Analytical Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 9, 2025

Early and precise diagnosis of neurodegenerative disorders like Alzheimer's (AD) Parkinson's (PD) is crucial for slowing their progression enhancing patient outcomes. Exosomal microRNAs (miRNAs) are emerging as promising biomarkers due to ability reflect the diseases' pathology, yet low abundance poses significant detection hurdles. This review article delves into burgeoning field electrochemical biosensors, designed exosomal miRNA biomarkers. Electrochemical biosensors offer a compelling solution, combining sensitivity required detect low-abundance with specificity needed discern profiles distinctive neural pathological states. We explore operational principles these including transduction mechanisms that facilitate detection. The also summarizes advancements in nanotechnology, signal enhancement, bioreceptor anchoring, microfluidic integration improve sensor accuracy. evidence use disease analyzed, focusing on clinical impact, diagnostic precision, obstacles faced practical applications. Their potential point-of-care testing regulatory considerations market entry discussed. Looking toward future, highlights forthcoming innovations might revolutionize early processes. impressive sensitivity, specificity, compatibility, track become instrumental diseases, possibly transforming care prognosis.

Language: Английский

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A Triple Signal Amplification Strategy for Accurate and Ultrasensitive miRNA-21 Detection

Analytical Chemistry, Journal Year: 2024, Volume and Issue: 96(36), P. 14464 - 14470

Published: Aug. 26, 2024

A triple signal amplification strategy was integrated with a built-in double electrode and external energy storage device to fabricate novel self-powered biosensor for ultrasensitive detection of miRNA-21. Specifically, DNA tetrahedra haripin2-glucose oxidase are modified on the surface biocathode bioanode by catalytic hairpin assembly (CHA) achieve dual amplification. Moreover, is realized including an capacitor. Consequently, as-constructed demonstrates low limit 0.06 fM toward miRNA-21 assay within range 0.1 10 pM. This study presents practical sensitive approach timely cancer detection.

Language: Английский

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Applications of Carbon-Based Multivariable Chemical Sensors for Analyte Recognition

Nano-Micro Letters, Journal Year: 2025, Volume and Issue: 17(1)

Published: May 3, 2025

Abstract Over recent decades, carbon-based chemical sensor technologies have advanced significantly. Nevertheless, significant opportunities persist for enhancing analyte recognition capabilities, particularly in complex environments. Conventional monovariable sensors exhibit inherent limitations, such as susceptibility to interference from coexisting analytes, which results response overlap. Although arrays, through modification of multiple sensing materials, offer a potential solution recognition, their practical applications are constrained by intricate material processes. In this context, multivariable emerged promising alternative, enabling the generation outputs construct comprehensive space while utilizing single material. Among various carbon nanotubes (CNTs) and graphene ideal candidates constructing high-performance sensors, owing well-established batch fabrication processes, superior electrical properties, outstanding capabilities. This review examines progress focusing on CNTs/graphene materials field-effect transistors transducers recognition. The discussion encompasses fundamental aspects these including architectures, performance metrics, pattern algorithms, mechanism. Furthermore, highlights innovative extraction schemes when integrated with algorithms.

Language: Английский

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Recent Advances in the miRNA-Mediated Regulation of Neuronal Differentiation and Death

NeuroMolecular Medicine, Journal Year: 2024, Volume and Issue: 26(1)

Published: Dec. 8, 2024

Language: Английский

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