Construction of nucleus-targeted photosensitizer and highly effective photodynamic immunotherapy for cancer DOI
Yuanpeng Liao, Xiaoping Lin,

Zhenhu He

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108022 - 108022

Published: Dec. 1, 2024

Language: Английский

A PDI-based NIR-II fluorescence imaging guided molecular phototheranostic platform for GSH-triggered gas therapy, mild photothermal therapy and NIR-activated photodynamic therapy DOI
Wei Zhou,

Di He,

Ning Liu

et al.

Chinese Chemical Letters, Journal Year: 2025, Volume and Issue: unknown, P. 110854 - 110854

Published: Jan. 1, 2025

Language: Английский

Citations

1
Near‐Infrared Multiple‐Resonance Polycyclic Aromatic Hydrocarbon as Type I Photosensitizer Toward High‐Performance Synergistic Phototherapy DOI
Yulong Shi, Wei Yang, He Zhang

et al.

Advanced Functional Materials, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 23, 2025

Abstract Type I photosensitization is of particular significance in the anaerobic tumor treatment. Nonetheless, development high‐performance type photosensitizers (PSs) remains challenging, due to weak absorption and inefficient intersystem crossing (ISC) progress. Herein, an effective approach toward a near‐infrared (NIR) PS ( NIR‐BN ) demonstrated using boron/nitrogen‐embedded polycyclic aromatic hydrocarbon with multiple‐resonance (MR) character, for first time. A small singlet‐triplet splitting (Δ E ST = 0.09 eV) high molar extinction coefficient (3.3 × 10 4 M −1 cm NIR MR‐configured supports efficient ISC triplet sensitization. The distorted molecular configurations induce multi‐model structural relaxations after optical excitation, resulting remarkable photothermal conversion efficiency exceeding 50% nanoparticles. Of note, nanoparticles are capable generating highly toxic superoxide anion radical (O 2 •− under 660 nm laser irradiation, benefiting from vigorous intramolecular dihedral angle vibrations excited states. Consequently, biocompatible demonstrates superior performance vivo synergistic photodynamic therapies.

Language: Английский

Citations

0
Advancements in small molecule fluorescent probes for the detection of formaldehyde in environmental and food samples: A comprehensive review DOI
Pengfei Wang,

Minggui Gong,

Ru‐Song Zhao

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144041 - 144041

Published: March 1, 2025

Language: Английский

Citations

0
Versatile albumin as a booster to optimize the excited state energy redistribution in photosensitizers enabling fluorescence imaging-guided photodynamic therapy DOI
Ting Wang, Lixin Ma,

Yingcui Bu

et al.

Chemical Engineering Journal, Journal Year: 2025, Volume and Issue: unknown, P. 163896 - 163896

Published: May 1, 2025

Language: Английский

Citations

0
Two-pronged strategy: A mitochondria targeting AIE photosensitizer for hydrogen sulfide detection and type I and type II photodynamic therapy DOI

Jizhong Shi,

Manshan Liang,

Yiting Qiu

et al.

Talanta, Journal Year: 2024, Volume and Issue: 282, P. 127074 - 127074

Published: Oct. 18, 2024

Language: Английский

Citations

3
Applications of Nanotheranostic in the Second Near-Infrared Window in Bioimaging and Cancer Treatment DOI
Huimin Li, Pengju Li, Jiarui Zhang

et al.

Nanoscale, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Achieving accurate and efficient tumor imaging is crucial in the field of treatment, as it facilitates early detection precise localization tissues, thereby informing therapeutic strategies surgical interventions. The optical technology within second near-infrared (NIR-II) window has garnered significant interest for its remarkable benefits, such enhanced tissue penetration depth, superior signal-to-background ratio (SBR), minimal autofluorescence, reduced photon attenuation, lower scattering. This review explained design optimization nano-agents responsive to NIR-II window, single-walled carbon nanotubes, quantum dots, lanthanum-based nanomaterials, noble metal nanomaterials. These enable non-invasive, deep-tissue with high spatial resolution their properties significantly improve accuracy, efficiency, versatility imaging-guided treatments. And we discussed characteristics advantages fluorescence (FL)/photoacoustic (PA) providing a comprehensive overview latest research progress different FL/PA therapy. Furthermore, exhaustively reviewed applications multifunctional nano-phototherapy technologies carried out by light including photothermal therapy (PTT), photodynamic (PDT), combined modalities like photothermal-chemodynamic (PTT-CDT), photothermal-chemotherapy (PTT-CT), photothermal- immunotherapy (PTT-IO). integrated approaches have gradually matured over past decade are expected become safe effective non-invasive treatment. Finally, outlined prospects challenges development innovation diagnosis nanoplatform. aims provide insightful perspectives future advancements treatment platforms.

Language: Английский

Citations

2
Molecular Engineering of membrane structure targeted photosensitizers for antitumor photodynamic therapy DOI
Xiaojuan Wang, Xin Liu, Wei Lü

et al.

Dyes and Pigments, Journal Year: 2024, Volume and Issue: unknown, P. 112497 - 112497

Published: Oct. 1, 2024

Language: Английский

Citations

0
Construction of nucleus-targeted photosensitizer and highly effective photodynamic immunotherapy for cancer DOI
Yuanpeng Liao, Xiaoping Lin,

Zhenhu He

et al.

Bioorganic Chemistry, Journal Year: 2024, Volume and Issue: 154, P. 108022 - 108022

Published: Dec. 1, 2024

Language: Английский

Citations

0