Flexible Screen‐Printed Electrochemical Sensor for Alkaline Phosphatase Detection in Biofluids for Biomedical Applications

ChemistryOpen, Journal Year: 2025, Volume and Issue: unknown

Published: April 13, 2025

Alkaline phosphatase (ALP) is an enzyme present in the human body responsible for dephosphorylation of phosphorylated chemical species. It primarily expressed organs such as bones, liver, intestine, and placenta during pregnancy, playing a crucial role cellular processes like gene expression, transport, metabolism. Physiological ALP levels vary with age sex, normal serum ranges healthy adults between 40 190 U/L. Alterations can be indicative several pathologies, including cancer diagnosis metastasis, well bone growth dysfunctions hypophosphatasia. Conventional methods detection often require complex assay principles, extensive sample pretreatment, trained personnel. Herein, development portable, flexible electrochemical sensor fabricated through screen‐printing to monitor biological samples introduced. The sensor, characterized by high efficiency, sustainability, low cost, ease disposal, achieves limit 0.03 0.08 U/L, respectively, buffer solution samples, satisfactory repeatability lower than 10%. This simple configuration approach enables real‐time disease monitoring improves access point‐of‐care diagnostics, paving way affordable, decentralized sensors that support early better healthcare.

Language: Английский

A CRISPR/Cas12a mediated click immunoassay catalyzed by in situ formation of clickase for highly sensitive detection of Trichinella spiralis

Biosensors and Bioelectronics, Journal Year: 2025, Volume and Issue: unknown, P. 117521 - 117521

Published: April 1, 2025

Language: Английский

Ratiometric electrochemical detection of alkaline phosphatase based on SWCNTs/Cu-MOF modified graphite paper electrodes

Microchemical Journal, Journal Year: 2024, Volume and Issue: unknown, P. 111934 - 111934

Published: Oct. 1, 2024

Language: Английский