Organic Radiosensitizer with Aggregation-Induced Emission Characteristics for Tumor Ablation through Synergistic Apoptosis and Immunogenic Cell Death DOI
Danni Xie,

Xueke Yan,

Shangping Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Inspired by the clinical application of thermotherapy to promote efficacy radiotherapy, this study demonstrates multimodal diagnostic pure organic nanoparticles in combined treatment tumors through imaging and photothermal properties. The developed demonstrated unique properties multiple functionalities, including excellent photostability thermostability, strong fluorescence emission near-infrared-II (NIR-II) region, extremely high conversion efficiency, good biocompatibility, significant radiosensitizing properties, effective tumor site accumulation. In vitro vivo evaluations that these are ideal candidates for synergistic radiotherapy guided NIR-II fluorescence, NIR-I photoacoustic, trimodal imaging. They act as radiosensitizers alleviating hypoxic microenvironment, modulating cell cycle, inducing apoptosis immunogenic death during which may provide a potential approach tumors.

Language: Английский

Organic Radiosensitizer with Aggregation-Induced Emission Characteristics for Tumor Ablation through Synergistic Apoptosis and Immunogenic Cell Death DOI
Danni Xie,

Xueke Yan,

Shangping Wang

et al.

ACS Nano, Journal Year: 2025, Volume and Issue: unknown

Published: April 9, 2025

Inspired by the clinical application of thermotherapy to promote efficacy radiotherapy, this study demonstrates multimodal diagnostic pure organic nanoparticles in combined treatment tumors through imaging and photothermal properties. The developed demonstrated unique properties multiple functionalities, including excellent photostability thermostability, strong fluorescence emission near-infrared-II (NIR-II) region, extremely high conversion efficiency, good biocompatibility, significant radiosensitizing properties, effective tumor site accumulation. In vitro vivo evaluations that these are ideal candidates for synergistic radiotherapy guided NIR-II fluorescence, NIR-I photoacoustic, trimodal imaging. They act as radiosensitizers alleviating hypoxic microenvironment, modulating cell cycle, inducing apoptosis immunogenic death during which may provide a potential approach tumors.

Language: Английский

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