Genes Are Tools of Intelligent Cells DOI
Arthur S. Reber, František Baluška, William B. Miller

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 105 - 122

Published: Oct. 5, 2023

Abstract In our biological system, self-referential cognitive competent cells assess imperfect information individually and collectively to solve cell-centred problems. Accordingly, the conscious cell is epicentre of activity. The cellular measurement environmental cues depends on a cell-wide senomic apparatus highly refined management system. real-time assessment ambiguous drives evolution as informational interactome by which can make productive cell-based predictions from cues. 20th century, neo-Darwinian Modern Synthesis dominated evolutionary narrative, whose cardinal assumptions were that resulted random genetic mutations natural selection. construct, genes viewed driver. Twenty-first-century biology recognizes are tools intelligent measuring cells. Decades contemporary research reveal central genome represents one among many contributors retrievable deployable memory systems Consequently, participants in complex information-based activities crucial archive successful viral–cellular solutions large body contributory sources code continuously assist greater narrative assimilation external environment.

Language: Английский

Genesis of Mitochondria to Power Complex Lifeforms DOI
David F. Stowe

Published: Jan. 1, 2025

Language: Английский

Citations

0
Structural Features and Synteny Analysis of the Sea Buckthorn Mitochondrial Genome DOI
Lei Ding, Yanli Tong, J. Zhang

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 23, 2025

Abstract Background Sea buckthorn (Hippophae rhamnoides L.) is a plant of significant economic, culinary, medicinal, ecological, and societal value. In order to gain deeper understanding the sea mitochondrial genome, sequencing assembly genome was performed, its substructures were explored in this study. Results The seabuckthorn consists two circular chromosomes, with lengths 297,507 bp 167,037 bp, respectively. It encompasses 36 annotated protein-coding genes, 3 rRNA 25 tRNA genes. addition, 212 pairs repeats detected, including pair that mediated homologous recombination chromosomes form conformations. existence these conformations confirmed through PCR amplification Sanger sequencing. A total 162 SSR loci identified genome. There are 30 fragments chloroplast genomes, length 44,950 accounting for 9.89% genomes. Conclusions summary, study conducted annotation providing comprehensive plant. This knowledge great significance effective utilization genetic improvement seabuckthorn, especially breeding evolutionary analysis cytoplasmic male sterility.

Language: Английский

Citations

0
Sentient cells as basic units of tissues, organs and organismal physiology DOI Creative Commons
František Baluška, William B. Miller, Arthur S. Reber

et al.

The Journal of Physiology, Journal Year: 2023, Volume and Issue: 602(11), P. 2491 - 2501

Published: Oct. 17, 2023

Cells evolved some 4 billion years ago, and since then the integrity of structural functional continuity cellular life has been maintained via highly conserved ancient processes cell reproduction division. The plasma membrane as well all cytoplasmic structures are reproduced inherited uninterruptedly by each two daughter cells resulting from every Although our understanding evolutionary emergence very first is obscured extremely long timeline that revolutionary event, generally accepted position de novo formation not possible; present products other prior cells. This essential biological principle was discovered Robert Remak effectively coined Omnis Cellula e (every cell) Rudolf Virchow: currently living have direct connections to Based on previous theoretical analysis, endowed with individual sentient cognition guides their agency, behaviour evolution. There a vital consequence this new cognitive view cells: when assemble tissue ecologies organs within multicellular organisms, including plants, animals humans, these aggregates display derivative versions aggregate tissue- organ-specific sentience consciousness. innovative evolution physiology organisms supports singular principle: organismal based extends unicellular roots.

Language: Английский

Citations

9
Self-empowerment of life through RNA networks, cells and viruses DOI Creative Commons

Luis P. Villarreal,

Guenther Witzany

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 138 - 138

Published: March 6, 2023

Our understanding of the key players in evolution and development all organisms domains life has been aided by current knowledge about RNA stem-loop groups, their proposed interaction motifs an early world regulative roles steps substeps nearly cellular processes, such as replication, transcription, translation, repair, immunity epigenetic marking. Cooperative was enabled promiscuous interactions between single-stranded regions loops naturally forming structures RNAs. It also shown that cooperative stem-loops outcompete selfish ones provide foundational self-constructive groups (ribosome, editosome, spliceosome,etc.). Self-empowerment from abiotic matter to biological behavior does not just occur at beginning evolution; it is essential for levels socially interacting RNAs, cells viruses.

Language: Английский

Citations

7
The Sentient Cell DOI
Arthur S. Reber, František Baluška, William B. Miller

et al.

Published: Feb. 27, 2024

The premise of this volume is that there a continuum semiotic agents across biology, extending from the first individually competent cells to their colonial aggregations and then further becoming functioning tissue ecologies, multicellular eukaryotic organisms, holobionic species. This same agency propels collective human thought our organizations, including nations or political movements. Our contribution explains causal chain by focusing on conscious cell. In recent publications, we have argued presented empirical evidence for sentience/cognition in all unicellular prokaryotes Homo sapiens . Put simply, life sentience are coterminous. All living biological entities, feel, learn, remember, choose, react, communicate. biosemiotic agents. Therefore, evolutionary development directly related intelligent suite sentient, problem-solving behaviors. perspective has been codified as Cellular Basis Consciousness (CBC), its particulars chapter. Several critical ramifications derive within parameters cellular sentience. Notably, consciousness exists an organized whole such even meaningful experiences at scale include semantic elements. requires interactive external membrane, separating internal milieu cell environment. That perceptive membrane must link retrievable deployable memory enable learning effective problem-solving. complex receptive apparatus supporting termed senome, representing pivotal architecture connecting interior CBC, aspects coordinate support sentience, architecture, genes, tools. Because any information about environment travel media interact with transit intervening environmental degraded compared source. inescapable informational ambiguity means measure gauge validity. Consequently, self-generated interior. create own reality. So do other CBC asserts creatures conscious, plants. On hand, non-biological cannot be since they not living. Creating creating life, which, date, unable do.

Language: Английский

Citations

2
Sensing, feeling and sentience in unicellular organisms and living cells DOI
František Baluška, William B. Miller, Predrag Slijepčević

et al.

Biosystems, Journal Year: 2024, Volume and Issue: 247, P. 105374 - 105374

Published: Nov. 17, 2024

Language: Английский

Citations

1
Self-empowerment of life through RNA networks, cells and viruses DOI Creative Commons

Luis P. Villarreal,

Guenther Witzany

F1000Research, Journal Year: 2023, Volume and Issue: 12, P. 138 - 138

Published: Feb. 6, 2023

Our understanding of the key players in evolution and development all organisms domains life has been aided by current knowledge about RNA stem-loop groups, their proposed interaction motifs an early world regulative roles steps substeps nearly cellular processes, such as replication, transcription, translation, repair, immunity epigenetic marking. Cooperative was enabled promiscuous interactions between single-stranded regions loops naturally forming structures RNAs. It also shown that cooperative stem-loops outcompete selfish ones provide foundational self-constructive groups (ribosome, editosome, spliceosome,

Language: Английский

Citations

3
Advanced Praise for The Sentient Cell: The Cellular Foundations of Consciousness DOI
Arthur S. Reber, František Baluška, William B. Miller

et al.

Published: Oct. 5, 2023

Extract The perfect book for any scientifically curious individual seeking updates to research on my favourite subject in all the world—the intelligent living cell.Brian J. Ford President Emeritus University of Cambridge Society Application Research (UK) most comprehensive vision post-neo-Darwinian biology date. Life is not about genes and digital information codes. sentience, consciousness, mind, intelligence. building blocks sentience consciousness are cells. A landmark that heralds a welcome paradigm shift biology.Predrag B. Slijepčević Department Sciences, Brunel London In 20 years researching biological cognition unicellular organisms I have studiously avoided what call ‘C-word’, consciousness. Sentient Cell has made me thoroughly reconsider reticence. It remarkable exposes standard model early 19th-century relic it is, providing abundant empirical evidence why should be supplanted. An excellent introduction necessary conversation will unfold over coming decades which sits squarely right side history. Vive la révolution!Pamela Lyon Adelaide (Australia)

Language: Английский

Citations

3
On the emergence of eukaryotes and other enigmas DOI
Gustavo Gollo

Biosystems, Journal Year: 2023, Volume and Issue: 231, P. 104958 - 104958

Published: July 12, 2023

Language: Английский

Citations

2
The Biological Information Cycle DOI
Arthur S. Reber, František Baluška, William B. Miller

et al.

Oxford University Press eBooks, Journal Year: 2023, Volume and Issue: unknown, P. 89 - 104

Published: Oct. 5, 2023

Abstract Biology is driven by self-referential cognition, which cells become aware of the uncertainties environmental cues. Cells evaluate ambiguous information through a cellular cycle as crucial tool problem-solving. Since all imprecise, must measure it. A senomic architecture supports that intricate process an integral component its management system. have learned validity (measuring value) their available can be improved shared assessment. This basal impulse stimulating factor leads to multicellularity. Consequently, informational ambiguity constitutes actual driver biological and evolutionary development reverberations among sentient cells. There growing recognition biomolecular processes represent flow equates with energy mobilization useful predictions. However, any productive requires channelling. The epicentre consciousness. Accordingly, are interactomes. As conscious, macro-organisms architectures, theory consciousness or mind should based on cell theory.

Language: Английский

Citations

1