The Paradox of the Self-Studying Brain

Physics of Life Reviews, Journal Year: 2025, Volume and Issue: 52, P. 197 - 204

Published: Jan. 7, 2025

Language: Английский

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Toward understanding the emergence of life: A dual function of the system of nucleotides in the metabolically closed autopoietic organization

Biosystems, Journal Year: 2023, Volume and Issue: 224, P. 104837 - 104837

Published: Jan. 14, 2023

General structure of metabolism includes the reproduction catalysts that govern metabolism. In this structure, system becomes autopoietic in sense Maturana and Varela, it is closed to efficient causation as defined by Robert Rosen. The maintenance operation takes place via set free nucleotides while synthesis occurs information encoded arranged polymers RNA DNA. Both energy charge genetic use components same pool nucleoside triphosphates, which equilibrated thermodynamic buffering enzymes such diphosphate kinase adenylate kinase. This a way internally stable metabolically closed, initially could be realized at level ribozymes catalyzing basic metabolic reactions well own reproduction. function ATP, GTP, UTP, CTP dual, these species participate both general transfer covalent polymerization nucleic acids. changes their pools directly impact bioenergetic pathways acid turnover. Here we outline concept closure biosystems grounded dual nucleotide coenzymes serve energetic informational molecules through duality generate performance ability for codepoietic evolutionary transformations living systems starting from emergence prebiotic systems.

Language: Английский

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Physical limits of natural computation as the biological constraints of morphogenesis, evolution, and consciousness: On the 100th anniversary of Efim Liberman (1925-2011)

Biosystems, Journal Year: 2025, Volume and Issue: unknown, P. 105451 - 105451

Published: March 1, 2025

Efim Liberman (1925-2011) introduced in 1972 the idea of natural computation realized internally by living systems. He considered physical principles employed systems as essential constraints that limit computational process occurring course adaptation, morphogenesis, and neural activity. The most general limits determined fundamental constants are universal for all nature. However, more specific intrinsic to each biological system can be overcome evolutionary process. We discuss roles macromolecules, particularly cytoskeleton, shaping actualization patterns formed internal measurement Cytoskeletal rearrangements determine cellular, morphogenetic, perceptive transformations participate combinatorial genetic events lead transformations. operation neurons is based on transmission signals via where digital output generated decoded through a reflexive action perceiving agent. It concluded formulated represent feature beings form basis theory systems, with consequences understanding metabolic closure, evolution, consciousness.

Language: Английский

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Macroevolution, differentiation trees, and the growth of coding systems

Biosystems, Journal Year: 2023, Volume and Issue: 234, P. 105044 - 105044

Published: Sept. 30, 2023

Language: Английский

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Reflexive neural circuits and the origin of language and music codes

Biosystems, Journal Year: 2024, Volume and Issue: unknown, P. 105346 - 105346

Published: Sept. 1, 2024

Language: Английский

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Reflexive structure of the conscious subject and the origin of language codes

Biosystems, Journal Year: 2023, Volume and Issue: 231, P. 104983 - 104983

Published: July 25, 2023

Language: Английский

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Nested Selves: Self‐Organization and Shared Markov Blankets in Prenatal Development in Humans

Topics in Cognitive Science, Journal Year: 2023, Volume and Issue: unknown

Published: Dec. 30, 2023

Abstract The immune system is a central component of organismic function in humans. This paper addresses self‐organization biological systems relation to—and nested within—other pregnancy. Pregnancy constitutes fundamental state for human embodiment and key step the evolution conservation our species. While not all humans can be pregnant, initial emerging growing within another person's body universal. Hence, pregnant does concern some individuals but individuals. Indeed, hierarchical relationship pregnancy reflects an even earlier autopoietic process embryo by which number single blastoderm dynamically determined cell– interactions. interactions between two self‐organizing during may play pivotal role understanding nature per se Specifically, we consider self‐ organization addition to neural/brain that furnish us with sense self. We examine complex case pregnancy, whereby need negotiate exchange resources information order maintain viable self‐regulation systems. conclude proposal mechanisms—that scaffold self‐organising pregnancy—through lens Active Inference, focus on shared Markov blankets.

Language: Английский

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Toward the Relational Formulation of Biological Thermodynamics

Entropy, Journal Year: 2023, Volume and Issue: 26(1), P. 43 - 43

Published: Dec. 31, 2023

Classical thermodynamics employs the state of thermodynamic equilibrium, characterized by maximal disorder constituent particles, as reference frame from which Second Law is formulated and definition entropy derived. Non-equilibrium analyzes fluxes matter energy that are generated in course general tendency to achieve equilibrium. The systems described classical non-equilibrium may be heuristically useful within certain limits, but epistemologically, they have fundamental problems application autopoietic living systems. We discuss here paradigm defined a relational biological thermodynamics. standard this refers relates function operating context particular environment not abstract This stable state, following Ervin Bauer. Similar physics, where abandoning absolute space-time resulted non-Euclidean geometry, leads revealing basic iterative structures formed consequence search for an optimal coordinate system organisms maintain non-equilibrium. Through search, developing achieves condition maximization its power via synergistic effects.

Language: Английский

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Overcoming the limits of natural computation in biological evolution toward the maximization of system efficiency

Biological Journal of the Linnean Society, Journal Year: 2022, Volume and Issue: 139(4), P. 539 - 554

Published: Sept. 22, 2022

Abstract The goal-directedness of biological evolution is realized via the anticipatory achievement final state system that corresponds to condition its perfection in self-maintenance and adaptability. In course individual development, a maximizes power synergistic effects becomes able perform external work most efficiently. this state, defined as stasis, robust self-maintaining configurations act attractors resistant internal perturbations. This local energy–time constraints efficiently fit integral optimization whole system. evolution, major evolutionary transitions establish new states stasis are achieved codepoiesis, process which undecided statements existing coding systems form basis for unfolding by assigning values them. genetic fixation macroevolutionary leads programmes development representing natural computation. phenomenon complexification represents metasystem transition results maximization system’s ability increase performed

Language: Английский

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Disgust as a primary emotional system and its clinical relevance

Frontiers in Psychology, Journal Year: 2024, Volume and Issue: 15

Published: Aug. 28, 2024

This paper advocates for considering disgust as a primary emotional system within Panksepp's Affective Neuroscience framework, which has the potential to improve efficacy of psychotherapy with obsessive-compulsive disorder, hypochondriasis, and emetophobia. In 2007, Toronchuk Ellis provided comprehensive evidence that DISGUST system, they defined it, matched all criteria system. A debate ensued was not unambiguously resolved. is an attempt resume this discussion supplement it data accumulated since then on DISGUST's relationship immune role dysregulation in psychopathology. We hope renewed research interest clinical hard-to-treat conditions.

Language: Английский

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