Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(3), P. 166 - 166
Published: March 4, 2023
Triple-negative
breast
cancer
(TNBC)
represents
an
aggressive
subtype
of
(BC)
with
a
typically
poorer
prognosis
than
other
subtypes
BC
and
limited
therapeutic
options.
Therefore,
new
drugs
would
be
particularly
welcome
to
help
treat
TNBC.
Preussin,
isolated
from
the
marine
sponge-associated
fungus,
Aspergillus
candidus,
has
shown
potential
reduce
cell
viability
proliferation
as
well
induce
death
cycle
arrest
in
2D
culture
models.
However,
studies
that
better
mimic
tumors
vivo,
such
3D
cultures,
are
needed.
Here,
we
studied
effects
preussin
MDA-MB-231
line,
comparing
using
ultrastructural
analysis
MTT,
BrdU,
annexin
V-PI,
comet
(alkaline
FPG
modified
versions),
wound
healing
assays.
Preussin
was
found
decrease
viability,
both
dose-dependent
manner,
impair
proliferation,
death,
therefore
excluding
hypothesis
genotoxic
properties.
The
cellular
impacts
were
reflected
by
alterations
also
significantly
inhibited
migration
cells.
data
expanded
knowledge
on
actions
while
supporting
studies,
highlighting
its
molecule
or
scaffold
for
development
anticancer
against
Journal of Biomolecular Structure and Dynamics,
Journal Year:
2023,
Volume and Issue:
42(8), P. 3983 - 4001
Published: May 26, 2023
AbstractAbstractThe
new
coronavirus
variant
(SARS-CoV-2)
and
Zika
virus
are
two
world-wide
health
pandemics.
Along
history,
natural
products-based
drugs
have
always
crucially
recognized
as
a
main
source
of
valuable
medications.
Considering
the
SARS-CoV-2
proteases
(Mpro)
re-production
key
element
viral
cycle
its
target,
herein
we
report
an
intensive
computer-aided
virtual
screening
for
focused
list
39
marine
lamellarins
pyrrole
alkaloids,
against
using
set
combined
modern
computational
methodologies
including
molecular
docking
(MDock),
molecule
dynamic
simulations
(MDS)
structure-activity
relationships
(SARs)
well.
Indeed,
studies
had
revealed
four
promising
alkaloids
[lamellarin
H
(14)/K
(17)]
S
(26)/Z
(39)],
according
to
their
notable
ligand-protein
energy
scores
relevant
binding
affinities
with
pocket
residues,
respectively.
Consequentially,
these
chemical
hits
were
further
examined
thermodynamically
though
investigating
MD
at
100
ns,
where
they
showed
prominent
stability
within
accommodated
pockets.
Moreover,
in-deep
SARs
suggested
crucial
roles
rigid
fused
polycyclic
ring
system,
particularly
aromatic
A-
F-
rings,
position
phenolic
-OH
δ-lactone
functionalities
essential
structural
pharmacophoric
features.
Finally,
investigated
in-silico
ADME
SWISS
platform,
displayed
appropriated
drug-likeness
properties.
Such
motivating
outcomes
greatly
recommending
in
vitro/vivo
examinations
regarding
those
(LPAs).Communicated
by
Ramaswamy
H.
SarmaKeywords:
SARS-CoV-2Zika
virusantiviralmarine
spongeslamellarins
alkaloidsmolecular
dockingdynamics
simulation
AcknowledgmentsAmr
El-Demerdash
is
immensely
grateful
his
home
university,
Mansoura
University,
Egypt,
unlimited
support
inside
outside.
The
authors
thank
Tobin
Florio
(http://flozbox-science.com/)
scientific
illustrations
Figures
1
2.
Amr
John
Innes
Centre,
Norwich
Research
Park,
United
Kingdom
postdoctoral
fellowship.
Florbela
Pereira
would
like
Fundacão
para
Ciência
e
Tecnologia,
MCTES,
scope
project
UIDB/50006/2020
Unit,
Associate
Laboratory
Green
Chemistry,
LAQVDisclosure
statementThe
declare
that
no
known
competing
financial
interests
or
personal
could
appeared
influence
work
reported
this
paper.Credits
authorship
contributionConceptualization:
Pereira,
Reem
K.
Arafa
El-Demerdash.
Validation:
Formal
analysis:
Investigation:
Loay
Bedda,
Mohamed
A.
Tammam,
Abdul
Kader
Alabdullah,
Resources:
Data
curation:
Writing
original
draft:
Writing-review
&
editing:
El-Demerdash.Additional
informationFundingAmr
Kingdom,
LAQV.
PNAS Nexus,
Journal Year:
2022,
Volume and Issue:
1(4)
Published: Sept. 1, 2022
The
morphology,
physiology,
and
behavior
of
marine
organisms
have
been
a
valuable
source
inspiration
for
solving
conceptual
design
problems.
Here,
we
introduce
this
rich
rapidly
expanding
field
biomimetics,
identify
it
as
poorly
articulated
often
overlooked
element
the
ocean
economy
associated
with
substantial
monetary
benefits.
We
showcase
innovations
across
seven
broad
categories
biomimetic
(adhesion,
antifouling,
armor,
buoyancy,
movement,
sensory,
stealth),
use
framing
context
closer
consideration
increasingly
frequent
focus
on
deep-sea
life
an
design.
contend
that
biomimetics
is
not
only
"forgotten"
sector
economy,
but
has
potential
to
drive
appreciation
nonmonetary
values,
conservation,
stewardship,
making
well-aligned
notions
sustainable
blue
economy.
note,
however,
highest
ambitions
are
drives
sustainability,
also
greater
equity
inclusivity,
conclude
by
articulating
challenges
considerations
bringing
onto
trajectory.
Marine Drugs,
Journal Year:
2023,
Volume and Issue:
21(3), P. 166 - 166
Published: March 4, 2023
Triple-negative
breast
cancer
(TNBC)
represents
an
aggressive
subtype
of
(BC)
with
a
typically
poorer
prognosis
than
other
subtypes
BC
and
limited
therapeutic
options.
Therefore,
new
drugs
would
be
particularly
welcome
to
help
treat
TNBC.
Preussin,
isolated
from
the
marine
sponge-associated
fungus,
Aspergillus
candidus,
has
shown
potential
reduce
cell
viability
proliferation
as
well
induce
death
cycle
arrest
in
2D
culture
models.
However,
studies
that
better
mimic
tumors
vivo,
such
3D
cultures,
are
needed.
Here,
we
studied
effects
preussin
MDA-MB-231
line,
comparing
using
ultrastructural
analysis
MTT,
BrdU,
annexin
V-PI,
comet
(alkaline
FPG
modified
versions),
wound
healing
assays.
Preussin
was
found
decrease
viability,
both
dose-dependent
manner,
impair
proliferation,
death,
therefore
excluding
hypothesis
genotoxic
properties.
The
cellular
impacts
were
reflected
by
alterations
also
significantly
inhibited
migration
cells.
data
expanded
knowledge
on
actions
while
supporting
studies,
highlighting
its
molecule
or
scaffold
for
development
anticancer
against
