Electrochemical Sensing of Phenylalanine using Polyaniline-Based Molecularly Imprinted Polymers DOI

Sonia Sarangi,

Ravishankar Srivastava,

Jully Gogoi-Tiwari

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(41), P. 10258 - 10271

Published: Sept. 24, 2024

Polyaniline (PANI)-based molecularly imprinted polymers were investigated for their efficacy in sensing phenylalanine (Phe) when fabricated on both glassy carbon electrode (GCE) and indium tin oxide (ITO) sheets. This study highlights the superior performance of PANI-MIP/ITO over PANI-MIP/GCE Phe, with clear distinct redox responses. Molecular computation helps to understand interaction mechanism between PANI where molecular crowding, aggregated clusters, hydrogen bonding, π-π stacking facilitate stable interactions. We tested specificity Phe by PANI-MIP different amino acids such as cysteine, tryptophan, tyrosine well organic molecules ascorbic acid, allantoin, sucrose, urea, confirming its remarkable electrochemical efficiency. The oxidation response curve yielded a limit detection 4.88 μM quantification 16.3 μM, comparable or better than earlier reported sensors. work demonstrates promise MIP-based sensing. It also lays groundwork future investigations into optimizing PANI-MIPs nanocomposites develop more selective

Language: Английский

Specific and sensitive detection of capsaicin for edible oils authentication using fluorescent molecularly imprinted silica particles DOI
Jinjin Wang,

Xinping Yu,

Haijuan Zhao

et al.

Food Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 144632 - 144632

Published: May 1, 2025

Language: Английский

Citations

0
State‐of‐the‐Art Synthesis of Porous Polymer Materials and Their Several Fantastic Biomedical Applications: a Review DOI Open Access
Yohannis Wondwosen Ahmed, Alexandrе Loukanov, Hsieh‐Chih Tsai

et al.

Advanced Healthcare Materials, Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 26, 2024

Porous polymers, including hydrogels, covalent organic frameworks (COFs), and hyper crosslinked polymers (HCPs), have become essential in biomedical research for their tunable pore architectures, large surface areas, functional versatility. This review provides a comprehensive overview of classification updated synthesis mechanisms, such as 3D printing, electrospinning, molecular imprinting. Their pivotal roles drug delivery, tissue engineering, wound healing, photodynamic/photothermal therapies, focusing on how size, distribution, architecture impact release, cellular interactions, therapeutic outcomes, are explored. Key challenges, biocompatibility, mechanical strength, controlled degradation, scalability, critically assessed alongside emerging strategies to enhance clinical potential. Finally, recent challenges future perspectives, emphasizing the broader applications porous addressed. work valuable insights advancing next-generation innovations through these materials.

Language: Английский

Citations

2
Troponin I Biomarker Sensing Using Molecularly Imprinted Polymer Nanoparticles for Advancing Healthcare Approaches in Cardiovascular Disease DOI
Joshua Saczek,

Oliver Jamieson,

Jake McClements

et al.

Published: Jan. 1, 2024

Language: Английский

Citations

1
Effect of Various Carbon Electrodes on MIP-Based Sensing Proteins Using Poly(Scopoletin): A Case Study of Ferritin DOI Creative Commons
Aysu Yarman

Biomimetics, Journal Year: 2024, Volume and Issue: 9(7), P. 426 - 426

Published: July 13, 2024

Sensitivity in the sub-nanomolar concentration region is required to determine important protein biomarkers, e.g., ferritin. As a prerequisite for high sensitivity, this paper, affinity of functional monomer macromolecular target ferritin solution was compared with value respective molecularly imprinted polymer (MIP)-based electrodes, and influence various surface modifications electrode investigated. The analytical performance sensing investigated using three different carbon electrodes (screen-printed single-walled-carbon-nanotube-modified screen-printed glassy electrodes) covered scopoletin-based MIP layer. Regardless type, template molecule mixed scopoletin, electropolymerization conducted multistep amperometry. All stages preparation were followed by evaluating diffusional permeability redox marker ferricyanide/ferrocyanide through layer differential pulse voltammetry. best results obtained electrodes. sensor responded up 0.5 µM linearly Kd 0.30 µM. Similar also upon interaction scopoletin fluorescence spectroscopy, resulting quenching signal, calculated 0.81 Moreover, binding 1 led 49.6% suppression, whereas human serum albumin caused 8.6% suppression.

Language: Английский

Citations

1
Electrochemical Sensing of Phenylalanine using Polyaniline-Based Molecularly Imprinted Polymers DOI

Sonia Sarangi,

Ravishankar Srivastava,

Jully Gogoi-Tiwari

et al.

The Journal of Physical Chemistry B, Journal Year: 2024, Volume and Issue: 128(41), P. 10258 - 10271

Published: Sept. 24, 2024

Polyaniline (PANI)-based molecularly imprinted polymers were investigated for their efficacy in sensing phenylalanine (Phe) when fabricated on both glassy carbon electrode (GCE) and indium tin oxide (ITO) sheets. This study highlights the superior performance of PANI-MIP/ITO over PANI-MIP/GCE Phe, with clear distinct redox responses. Molecular computation helps to understand interaction mechanism between PANI where molecular crowding, aggregated clusters, hydrogen bonding, π-π stacking facilitate stable interactions. We tested specificity Phe by PANI-MIP different amino acids such as cysteine, tryptophan, tyrosine well organic molecules ascorbic acid, allantoin, sucrose, urea, confirming its remarkable electrochemical efficiency. The oxidation response curve yielded a limit detection 4.88 μM quantification 16.3 μM, comparable or better than earlier reported sensors. work demonstrates promise MIP-based sensing. It also lays groundwork future investigations into optimizing PANI-MIPs nanocomposites develop more selective

Language: Английский

Citations

1