Gut microbiota and risk of iron deficiency anemia: A two-sample Mendelian randomization study
Wenhui Lei,
No information about this author
Zhaoyun Liu,
No information about this author
Hai-Ping Lai
No information about this author
et al.
Medicine,
Journal Year:
2025,
Volume and Issue:
104(8), P. e41617 - e41617
Published: Feb. 21, 2025
Previous
studies
have
suggested
a
link
between
gut
microbiota
and
iron-deficiency
anemia
(IDA).
However,
interpreting
these
findings
is
difficult
due
to
various
factors
that
influence
microbiome
composition
the
limitations
of
observational
studies,
such
as
confounding
variables
reverse
causation.
This
study
aims
explore
causal
relationship
IDA
using
Mendelian
randomization
(MR)
overcome
limitations.
We
conducted
2-sample
MR
analysis
data
from
genome-wide
association
MiBioGen
Consortium
UK
Biobank.
The
included
211
genus-level
microbes
linked
single-nucleotide
polymorphisms
18,340
participants
in
Consortium.
outcome
for
were
obtained
484,598
Biobank,
with
2941
cases
481,657
controls.
assessed
relationships
techniques,
primarily
inverse
variance
weighting,
performed
sensitivity
analyses
confirm
robustness
our
results.
Nine
significantly
associated
(
P
<
.05).
Protective
Clostridia,
Actinomycetaceae,
Pasteurellaceae,
Oscillospira,
Prevotella,
Roseburia,
while
risk
Ruminococcus
gnavus
group,
Hungatella,
Parasutterella.
Sensitivity
showed
reliability
without
significant
variability.
provides
evidence
specific
bacteria
risk,
identifying
potential
targets
therapies
aimed
at
improving
outcomes
those
IDA.
Further
research
needed
clarify
involved.
Language: Английский
Advancing Wastewater-Based Biohydrogen Production Through Microbial Engineering and Process Innovations
Current Pollution Reports,
Journal Year:
2025,
Volume and Issue:
11(1)
Published: March 4, 2025
Language: Английский
Assessing the Efficiency and Mechanisms of Chlorobenzene Degradation Using an Immobilized Bacterial Consortium Supplemented with Micron Zerovalent Iron and Biomass
ACS ES&T Water,
Journal Year:
2025,
Volume and Issue:
unknown
Published: April 22, 2025
Language: Английский
Biohydrogen fermentation from pretreated biomass in lignocellulose biorefinery: Effects of inhibitory byproducts and recent progress in mitigation strategies
Zitong Zhao,
No information about this author
Shan-Shan Yang,
No information about this author
Geng Luo
No information about this author
et al.
Biotechnology Advances,
Journal Year:
2024,
Volume and Issue:
unknown, P. 108508 - 108508
Published: Dec. 1, 2024
Language: Английский
The potential of native and engineered Clostridia for biomass biorefining
Paola Ponsetto,
No information about this author
Emilia Malgorzata Sasal,
No information about this author
Roberto Mazzoli
No information about this author
et al.
Frontiers in Bioengineering and Biotechnology,
Journal Year:
2024,
Volume and Issue:
12
Published: Aug. 16, 2024
Since
their
first
industrial
application
in
the
acetone-butanol-ethanol
(ABE)
fermentation
early
1900s,
Clostridia
have
found
large
biomass
biorefining.
Overall,
products
include
organic
acids
(e.g.,
acetate,
butyrate,
lactate),
short
chain
alcohols
ethanol,
n-butanol,
isobutanol),
diols
1,2-propanediol,
1,3-propanediol)
and
H
2
which
several
applications
such
as
fuels,
building
block
chemicals,
solvents,
food
cosmetic
additives.
Advantageously,
clostridial
strains
are
able
to
use
cheap
feedstocks
lignocellulosic
biomass,
waste,
glycerol
or
C1-gases
(CO
,
CO)
confer
them
additional
potential
key
players
for
development
of
processes
less
dependent
from
fossil
fuels
with
reduced
greenhouse
gas
emissions.
The
present
review
aims
provide
a
survey
research
progress
aimed
at
developing
Clostridium
-mediated
processes,
especially
regards
strain
improvement
by
metabolic
engineering.
Language: Английский
Waste Nitrogen Upcycling to Amino Acids during Anaerobic Fermentation on Biochar: An Active Strategy for Regulating Metabolic Reducing Power
Environmental Science & Technology,
Journal Year:
2024,
Volume and Issue:
58(45), P. 20060 - 20072
Published: Nov. 1, 2024
This
study
proposes
a
novel
strategy
that
utilizes
biochar
(BC)
during
anaerobic
fermentation
(AF)
to
generate
amino
acids
(AAs)
toward
nitrogen
upcycling.
The
BC,
pyrolyzed
at
800
°C
(BC800)
enhance
graphite
structures
and
electron-accepting
sites,
effectively
addresses
issues
related
biosynthetic
reducing
power
nicotinamide
adenine
dinucleotide
phosphate
insufficiency
by
altering
cellular
conditions
alleviates
feedback
inhibition
through
the
immobilization
of
end
products.
process
establishes
unique
microbial
signaling
energy
networks,
with
Language: Английский