The Effectiveness of Curcumin Nanoparticle-Coated Titanium Surfaces in Osteogenesis: A Systematic Review DOI Creative Commons

Nandita Suresh,

Matti Mauramo, Tuomas Waltimo

et al.

Journal of Functional Biomaterials, Journal Year: 2024, Volume and Issue: 15(9), P. 247 - 247

Published: Aug. 27, 2024

(1) Background: This systematic review critically appraises and synthesizes evidence from in vitro studies investigating the effects of curcumin nanoparticles on titanium surface modification, focusing cell adhesion, proliferation, osteogenic differentiation, mineralization. (2) Methods: A comprehensive electronic search was conducted PubMed, Cochrane Central Register Controlled Trials, Google Scholar databases, yielding six that met inclusion criteria. The strategy study selection process followed PRISMA (Preferred Reporting Items for Systematic Reviews Meta-Analyses) guidelines. qualitative methodological assessment performed using SciRAP (Science Risk Assessment Policy) method, which evaluated reporting quality included studies. (3) Results: All consistently demonstrated curcumin-coated surfaces inhibited osteoclastogenesis promoted activity, evidenced by enhanced mean score 91.8 (SD = 5.7), 85.8 10.50), as assessed method. Half used hydroxyapatite-coated a control, while other half uncoated titanium, introducing potential variability baseline comparisons. (4) Conclusions: provides compelling supporting nanoparticle-coated surfaces. findings suggest this modification may enhance implants' biocompatibility properties, potentially improving dental orthopedic implant outcomes. However, highlights significant heterogeneity experimental designs concentration single research group. Further research, particularly vivo clinical trials diverse teams, is essential to validate these comprehensively understand translational promising approach.

Language: Английский

Recent advances of NFATc1 in rheumatoid arthritis-related bone destruction: mechanisms and potential therapeutic targets DOI Creative Commons
Hao Zheng, Y. Liu,

Yasi Deng

et al.

Molecular Medicine, Journal Year: 2024, Volume and Issue: 30(1)

Published: Feb. 3, 2024

Abstract Rheumatoid arthritis (RA) is a chronic autoimmune inflammatory disease characterized by inflammation of the synovial tissue and joint bone destruction, often leading to significant disability. The main pathological manifestation deformity in RA patients which occurs due differentiation proliferation osteoclasts. transcription factor nuclear factor-activated T cell 1 (NFATc1) plays crucial role this process. regulation NFATc1 osteoclast influenced three factors. Firstly, activated through upstream kappa-B ligand (RANKL)/RANK signaling pathway. Secondly, Ca 2+ -related co-stimulatory pathway amplifies activity. Finally, negative action cytokines such as B-cell Lymphoma 6 (Bcl-6), interferon regulatory 8 (IRF8), MAF basic leucine zipper B (MafB), LIM homeobox 2 (Lhx2). These phases collectively govern subsequently affect expression downstream target genes including TRAF6 NF-κB. Ultimately, intricate network mediates differentiation, fusion, degradation both organic inorganic components matrix. This review provides comprehensive summary recent advances understanding mechanism context RA-related destruction discusses potential therapeutic agents that NFATc1, with aim offering valuable insights for future research field RA. To assess their RA, we conducted drug-like analysis drugs precise structures.

Language: Английский

Citations

11
Curcumin-loaded scaffolds in bone regeneration DOI Creative Commons

Mohammad Ebrahim Astaneh,

Fariba Noori, Narges Fereydouni

et al.

Heliyon, Journal Year: 2024, Volume and Issue: 10(11), P. e32566 - e32566

Published: June 1, 2024

In recent years, there has been a notable surge in the development of engineered bone scaffolds intended for repair defects. While autografts and allografts have traditionally served as primary methods tissue engineering, their inherent limitations spurred exploration novel avenues biomedical implant development. The emergence not only facilitates reconstruction but also offers platform targeted delivery therapeutic agents. There exists pervasive interest leveraging various drugs, proteins, growth factors, biomolecules with osteogenic properties to augment formation, enduring side effects associated current clinical modalities necessitate pursuit safer alternatives. Curcumin, principal bioactive compound found turmeric, demonstrated efficacy regulating proliferation differentiation cells while promoting formation. Nevertheless, its utility is hindered by restricted water solubility poor bioavailability. Strategies aimed at enhancing solubility, stability, bioavailability curcumin, including formulation techniques such liposomes nanoparticles or complexation metals, explored. This investigation dedicated exploring impact curcumin on proliferation, differentiation, migration osteocytes, osteoblasts, osteoclasts.

Language: Английский

Citations

9
Different types of cell death and their interactions in myocardial ischemia–reperfusion injury DOI Creative Commons

Bingxin Du,

Qiang Fu, Qin Yang

et al.

Cell Death Discovery, Journal Year: 2025, Volume and Issue: 11(1)

Published: March 5, 2025

Myocardial ischemia-reperfusion (I/R) injury is a multifaceted process observed in patients with coronary artery disease when blood flow restored to the heart tissue following ischemia-induced damage. Cardiomyocyte cell death, particularly through apoptosis, necroptosis, autophagy, pyroptosis, and ferroptosis, pivotal myocardial I/R injury. Preventing death during of vital for improving ischemic cardiomyopathy. These multiple forms can occur simultaneously, interact each other, contribute complexity In this review, we aim provide comprehensive summary key molecular mechanisms regulatory patterns involved these five types We will also discuss crosstalk intricate interactions among mechanisms, highlighting interplay between different death. Furthermore, explore specific molecules or targets that participate pathways elucidate their action. It important note manipulating distinct processes may have significant impact on reducing By enhancing researchers' understanding injury, review aims pave way development novel interventions cardio-protection affected by

Language: Английский

Citations

2
Design and fabrication of functionalized curdlan-curcumin delivery system to facilitate the therapeutic effects of curcumin on breast cancer DOI
Showkat Ali Ganie, Rayees Ahmad Naik, Ovas Ahmad Dar

et al.

International Journal of Biological Macromolecules, Journal Year: 2024, Volume and Issue: 267, P. 131388 - 131388

Published: April 11, 2024

Language: Английский

Citations

5
Interruption of mitochondrial symbiosis is associated with the development of osteoporosis DOI Creative Commons
Haoling Zhang, Rui Zhao, Xuemei Wang

et al.

Frontiers in Endocrinology, Journal Year: 2025, Volume and Issue: 16

Published: Feb. 3, 2025

Mitochondria maintain bacterial traits because of their endosymbiotic origins, yet the host cell recognizes them as non-threatening since organelles are compartmentalized. Nevertheless, controlled release mitochondrial components into cytoplasm can initiate death, activate innate immunity, and provoke inflammation. This selective interruption endosymbiosis early 2 billion years ago allowed mitochondria to become intracellular signaling hubs. Recent studies have found that symbiosis may be closely related occurrence various diseases, especially osteoporosis (OP). OP is a systemic bone disease characterized by reduced mass, impaired microstructure, elevated fragility, susceptibility fracture. The intra-mitochondrial affects energy metabolism cells, leads imbalance formation absorption, promotes osteoporosis. In this paper, we reviewed mechanism intersymbiosis in OP, discussed relationship between marrow mesenchymal stem osteoblasts osteoclasts, well inheritance adaptation evolutionary process, prospected future research direction provide new ideas for clinical treatment.

Language: Английский

Citations

0
Comprehensive systematic review and meta-analysis on the therapeutic efficacy of curcumin in osteoporosis: unveiling mechanisms and preclinical evidence DOI Creative Commons

Shenglei Yang,

J. Wang,

F. C. Ma

et al.

Frontiers in Nutrition, Journal Year: 2025, Volume and Issue: 12

Published: May 21, 2025

Background Osteoporosis (OP) is a common degenerative bone disease that seriously affects the quality of life patients and poses significant public health burden. Curcumin (CUR), natural compound, has attracted much attention due to its anti-inflammatory, antioxidant protective effects. However, there currently lack systematic evaluation efficacy mechanism CUR in treating OP. Methods This study review meta-analysis conducted per PRISMA guidelines. Studies meeting inclusion criteria were retrieved screened from PubMed, Embase, Web Science, Cochrane Library databases. The included studies limited animal models OP, intervention group was treated with single dose CUR. A performed using Review Manager 5.4 R Studio software. standardized mean difference (SMD) 95% confidence interval (CI) calculated fixed-effect or random-effects model. Sources heterogeneity, sensitivity, publication bias also explored. Results total 17 high-quality involving 282 animals included. results metaanalysis showed compared control group, significantly increased mineral density (BMD femur: SMD = 2.18, CI: 1.53–2.83; BMD tibia: 1.08, 0.30–1.87), improved trabecular microstructure (BV/TV: 2.74, 1.84–3.64; Tb.N: 2.31, 1.65–2.96; Tb.Th: 2.09, 1.43–2.76; Tb.Sp: −2.32, −3.15 −1.50). In addition, reduced serum CTX-1 TRAP-5b levels, while increasing OCN ALP levels. Mechanism have shown may act through OPG/RANKL, Wnt/β-catenin, NF-κB, MAPK, TGF-β/Smad2/3 signaling pathways. Conclusion first systematically evaluate CUR's therapeutic effect on an OP show can improve pathological state osteoporosis multi-target good potential. heterogeneity differences literature suggest prospective are needed verify clinical value further.

Language: Английский

Citations

0
Curcumin inhibits PAT-induced renal ferroptosis via the p62/Keap1/Nrf2 signalling pathway DOI

Jianan Zhai,

Zhengguo Chen,

Qi zhu

et al.

Toxicology, Journal Year: 2024, Volume and Issue: 506, P. 153863 - 153863

Published: June 13, 2024

Language: Английский

Citations

3
The Inhibitory Effect of the Active Ingredients in the Bushen Huoxue Formula on the IL-17A Signaling Pathway and Its Alleviating Effect on Osteoarthritis DOI Creative Commons
Xuan Wang,

Yunheng Zhang,

Xin Chang

et al.

Journal of Inflammation Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 6505 - 6527

Published: May 1, 2025

Osteoarthritis (OA) stands as a prevalent degenerative disease worldwide. Despite the demonstrated therapeutic efficacy of Bushen Huoxue formula (BSHXF) in treating OA, its underlying mechanism remains elusive. Network pharmacology is commonly employed for investigating drug-disease associations and processes. In this study, we network alongside vitro vivo experiments to elucidate molecular by which BSHXF treats OA. Based on TCMSP database, active components were screened, OA-related targets retrieved from GeneCard DisGeNET construct "component-target-pathway" using Cytoscape. Core target functions pathways (KEGG/GO) analyzed through STRING Metascape, while component-target binding affinity was validated via Autodock. For experiments, an IL-1β-induced chondrocyte inflammation model established, key protein expression detected Western blot immunofluorescence. OA created medial meniscectomy knee joint rats, assessed histological staining micro-CT. This study screened 89 ingredients identified 189 common targets. pharmacological analysis revealed luteolin tanshinone IIA most crucial with BSHXF. The potential mechanisms action treatment involve inhibition, immune function regulation, resistance oxidative stress, significant regulatory role played IL-17 signaling pathway. Molecular docking results luteolin's strong such B-cell lymphoma 2 (Bcl-2), Matrix metalloproteinase-9 (Mmp-9), IL-6.In that significantly suppressed inflammatory responses chondrocytes, downregulating IL-17A (p < 0.05), reducing MMP-9 0.05) IL-6 inhibiting apoptosis. Additionally, high-dose group (150 mg/kg) markedly alleviated cartilage damage OARSI scores decreased compared 0.05). Micro-CT showed inhibited osteophyte formation ameliorated pathological conditions. has alleviate suppressing inflammation, apoptosis hindering extracellular matrix degradation Our elucidated effects thus highlighting further research implications novel drug candidate.

Language: Английский

Citations

0
Evolutionary edge: NOD-like receptors in immunity DOI Creative Commons
Aila Akosua Kattner

Biomedical Journal, Journal Year: 2024, Volume and Issue: 47(1), P. 100702 - 100702

Published: Jan. 30, 2024

This issue of the Biomedical Journal delves into multifaceted roles NOD-like receptors (NLRs) in immunity, examining their subfamilies and functions within innate adaptive autoimmune inflammatory conditions, mitophagy regulation. In this dynamics mRNA vaccines are explored, as well synergistic effects a ketogenic diet with anti-tumor therapies, curcumin RANKL osteoclastogenesis, validation rapid diagnostic test for an oral cancer biomarker. Additionally, advancements ocular care highlighted, featuring novel prodrug targeting corneal neovascularization, discussing efficacy dexamethasone implants against macular edema. Concluding, further insights impact sweetened foods on child development given.

Language: Английский

Citations

2
A Docking and Network Pharmacology Study on the Molecular Mechanisms of Curcumin in Dental Caries and Streptococcus mutans DOI Creative Commons
Juan Manuel Guzmán‐Flores, Ángel Pérez-Reyes, Sonia Isela Vázquez‐Jiménez

et al.

Dentistry Journal, Journal Year: 2024, Volume and Issue: 12(6), P. 153 - 153

Published: May 21, 2024

Background: Dental caries is a dynamic, multifactorial disease that destroys teeth and can affect anyone’s quality of life because it cause tooth loss make chewing difficult. involves various factors, such as Streptococcus mutans host factors. Currently, adjuvant therapies, curcumin, have emerged, but how they work has not been adequately described. Therefore, this aims to identify the molecular mechanism curcumin in mutans. Methods: We obtained differentially expressed genes from GEO dataset, targets were other databases. The common analyzed according gene ontology enrichment, key obtained, binding was verified by docking. Results: Our analysis showed presents 134 therapeutic caries. According analysis, these are mainly involved apoptosis inflammation. There seven proteins action on caries: MAPK1, BCL2, KRAS, CXCL8, TGFB1, MMP9, IL1B, all which spontaneously bind curcumin. In addition, affects metabolic pathways related lipid, purine, pyrimidine metabolism Conclusions: Curcumin both carious processes

Language: Английский

Citations

2