The role of miRNAs in the pathogenesis, diagnosis, and treatment of colorectal cancer and colitis-associated cancer

Clinical and Experimental Medicine, Journal Year: 2025, Volume and Issue: 25(1)

Published: March 16, 2025

MicroRNAs (miRNAs) are a group of noncoding single-stranded RNA biomolecules that act in posttranscriptional regulation gene expression. Their role the development inflammatory bowel disease (IBD), colitis-associated cancer (CAC), and colorectal (CRC) is currently under investigation. A few miRNAs present promising results terms diagnostic or therapeutic use, for example, miR-21 increases CRC inflammation, while also being possible target therapy; miR-301a inflammation but only patients with IBD; miR-31 CRC, especially advanced stages, namely III-IV TNM scale; miR-200 family plays carcinogenesis other tumors; examined as group, miR-31-5p, miR-223-3p, let-7f-5p trigger exacerbate CAC; miR-19a could potentially be used therapy prevention both CAC. Here, we discuss available studies outline future directions concerning validity using diagnosis and/or IBD, CAC, CRC. Extensive research confirms play an important pathogenesis CAC Since significantly altered expression certain early prognostic marker these diseases, have potential to serve tools, enabling quick straightforward detection.

Language: Английский

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Circadian rhythmicity and human health

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100855 - 100855

Published: April 1, 2025

Language: Английский

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Rhythms Under Tension: Circadian Clocks in an Unsynced Society

Biomedical Journal, Journal Year: 2025, Volume and Issue: unknown, P. 100873 - 100873

Published: May 1, 2025

Language: Английский

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