Effectiveness of perioperative low-dose esketamine infusion for postoperative pain management in pediatric urological surgery: a prospective clinical trial

BMC Anesthesiology, Journal Year: 2024, Volume and Issue: 24(1)

Published: Feb. 15, 2024

Postoperative pain is common in pediatric urological surgery. The study assess the impact of perioperative intravenous infusion low-dose esketamine on postoperative

Language: Английский

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Mapping Theme Trends and Research Frontiers in Dexmedetomidine Over Past Decade: A Bibliometric Analysis

Drug Design Development and Therapy, Journal Year: 2024, Volume and Issue: Volume 18, P. 3043 - 3061

Published: July 1, 2024

Dexmedetomidine, an α

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Effects of Dexmedetomidine as an Adjuvant in Preoperative Ultrasound-Guided Internal Branch of Superior Laryngeal Nerve Block on Postoperative Sore Throat and Hemodynamics in Patients With Double-Lumen Endotracheal Intubation: A Randomized Controlled Trial

Journal of Pain Research, Journal Year: 2025, Volume and Issue: Volume 18, P. 229 - 241

Published: Jan. 1, 2025

Postoperative sore throat (POST) is a significant adverse effect after endotracheal intubation, especially with double-lumen tubes (DLTs). Ultrasound-guided internal branch of the superior laryngeal nerve block (US-guided iSLNB) presents potential intervention for POST. In this first randomized controlled trial to date, we aimed investigate effects US-guided iSLNB, or without perineural dexmedetomidine, on incidence and severity POST following DLTs. A total 159 patients were randomly assigned three groups: control, bilateral iSLNB (2 mL 0.20% ropivacaine + 1 saline each side), combined dexmedetomidine group 0.5 μg·kg-1 side). The POST, hemodynamic fluctuations during intubation extubation, cough agitation perioperative complications assessed. primary outcome was at 6 h surgery. Compared control group, preoperative significantly reduced surgery, mitigated attenuated responses, including heart rate, mean arterial pressure, rate-pressure product min extubation (all P < 0.01). alone, combination 1, 6, 12 h, as well coughing However, it demonstrated little hemodynamics > 0.05). No observed in groups Preoperative effectively incidence, severity, duration extubation. additional benefits observed. Chinese Clinical Trial Registry (ChiCTR2200061001).

Language: Английский

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Clinical effects of intravenous patient-controlled analgesia with dexmedetomidine plus inhalation-intravenous combined anesthesia in patients with gastric cancer undergoing laparoscopic radical gastrectomy

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(1), P. 51 - 59

Published: Jan. 22, 2025

Language: Английский

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Clinical effects of intravenous patient-controlled analgesia with dexmedetomidine plus inhalation-intravenous combined anesthesia in patients with gastric cancer undergoing laparoscopic radical gastrectomy

Shijie huaren xiaohua zazhi, Journal Year: 2025, Volume and Issue: 33(1), P. 53 - 61

Published: Jan. 25, 2025

Language: Английский

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The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial

Drug Design Development and Therapy, Journal Year: 2025, Volume and Issue: Volume 19, P. 1971 - 1981

Published: March 1, 2025

Recently, opioid-sparing (OS) interventions have been proposed to facilitate rapid postoperative recovery for patients. However, the advantages of OS anesthesia strategy in laparoscopic abdominal major surgery are still unknown. 157 patients undergoing were randomly assigned two groups: Remi (77, remifentanil) and (80, esketamine combined with dexmedetomidine), drugs administered at 0.2-0.5 mg/kg/h (remifentanil or esketamine) 0.2-0.7μg/kg/h dexmedetomidine) syringes, respectively The primary outcome was numeric rating scale (NRS) pain score on day (POD)1. proportion rescue analgesia within 48 h, extubation time, quality recover (PQRS), Pittsburgh Sleep Quality Index (PSQI) POD30 also recorded. In postanaesthesia care unit (PACU), NRS group significantly higher than that (3 [1 3] vs 1 3], P = 0.001; 15.6% 5.0%, 0.028, respectively), although there no statistical differences POD1, POD7 between groups [2 3 0.648; 2 2] 2], 0.418; 0 1] 1], 0.656, respectively). time longer dreaminess (20 [11 34] 31 [21 40], < 0.01; 42.5%, 0.01), PSQI similar (8.27±3.94 8.37±3.89, 0.870). this study, during decreases scores PACU reduces use analgesia, though it may prolong increase hospitalization. ChiCTR2200060130.

Language: Английский

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Effects of the subanesthetic dose of esketamine on postoperative sleep quality in patients undergoing modified radical mastectomy: a randomized, double-blind controlled trial

Frontiers in Medicine, Journal Year: 2025, Volume and Issue: 12

Published: April 2, 2025

Breast cancer is the most common malignant tumor among women worldwide. Surgical intervention a critical component of treatment, yet associated stress and anxiety can significantly disrupt postoperative sleep quality. Emerging evidences suggest that esketamine may offer benefits in alleviating emotional distress enhancing sleep. The purpose this study was to observe effects intraoperative subanesthetic dose on patients undergoing modified radical mastectomy. This randomized, double-blind, controlled trial enrolled 145 female patients, who were randomly assigned either group (Group E, n = 72) or control C, 73). Patients Group E received (0.2 mg/kg loading dose, followed by 0.1 mg/kg/h infusion), while those C saline mL/kg mL/kg/h infusion). primary outcome total score Richards-Campbell Sleep Questionnaire (RCSQ) measured day (POD) 1. Secondary outcomes included recovery time, incidence adverse events rescue analgesia, Visual Analogue Scale (VAS) pain scores, short-form McGill's Pain (SF-MPQ) sensory affective Pittsburgh Quality Index (PSQI) scores. No significant differences observed RCSQ scores POD 1 between (median [interquartile range]: 46 [32-68] vs. 54 [40-71], p > 0.05). Recovery time longer compared (8 [5-11] 6 [4-11] minutes; 0.02). There no remedial analgesia within 48 h postoperatively. Furthermore, groups VAS SF-MPQ at 4, 24, PSQI 30 not different (p For without pre-existing disorders mastectomy, impact quality but potentially contribute prolonged time. registered Chinese Clinical Trial Registry July 03, 2022 (https://www.chictr.org.cn; Registration number: ChiCTR2200061818).

Language: Английский

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Progress of Clinical Application of Esketamine in Abdominal Tumor Surgery in Elderly Patients

Current anesthesiology reports, Journal Year: 2025, Volume and Issue: 15(1)

Published: April 7, 2025

Language: Английский

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Ascorbic Acid and Esketamine for Mental Disorders in Women with Miscarriage: A Randomized Controlled Double-Blind Trial Protocol

Neuropsychiatric Disease and Treatment, Journal Year: 2025, Volume and Issue: Volume 21, P. 815 - 825

Published: April 1, 2025

Pregnancy leads to vulnerabilities and susceptibilities mental disorders. Miscarriage, as an adverse pregnancy outcome, following curettage for treatment, add the risks of further psychiatric disorders, including depression, anxiety, insomnia, etc., current approaches prevention are unsatisfactory. Ketamine its S-enantiomer esketamine can prevent postpartum even treats depressive symptoms after miscarriage curettage, but their side effects bring limitations. Ascorbic acid (AA, Vitamin C) modulate mood enhance ketamine's antidepressant efficacy synergistically, reducing dosages potentially. The purpose this study is clarify beneficial modification AA on preventing depression other disorders in patients with painless well interaction between esketamine. This a 2×2 factorial, double-blinded, randomized, controlled trial that will recruit women undergoing curettage. A total 424 participants be recruited randomly 1:1:1:1 allocated four groups (106 each): Group A0K0 (normal saline normal saline), A0K1 esketamine), A1K0 (AA A1K1 esketamine). primary outcome incidence postoperative day 7, assessed Edinburgh Postnatal Depression Scale (EPDS). secondary outcomes include EPDS score, assessments sleep, pain, events, perianesthetic data patient satisfaction. provides clinical trial-based evidence alone or combination/interacting emerging rapid-acting Our expected suggest AA's potential application optimizing strategies promoting post-miscarriage health, possible adjunctive improvement (es)ketamine's usage antidepressants. One major limitation single-center study, results might biased due regional factors.

Language: Английский

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Effect of perioperative intravenous ketamine on postoperative sleep disturbance in patients undergoing non-cardiac surgery: A systematic review and meta-analysis

Indian Journal of Anaesthesia, Journal Year: 2025, Volume and Issue: 69(5), P. 434 - 449

Published: April 16, 2025

Background and Aims: Postoperative sleep disturbance (PSD) is a common condition that may lead to pain, cognitive impairment, depression, delayed recovery. This review evaluates the efficacy of perioperative intravenous ketamine in alleviating PSD offers evidence-based recommendations for clinical practice. Methods: A systematic search was performed PubMed, Embase, Cochrane Library, Wanfang Data, VIP Information Resource System, China National Knowledge Infrastructure Biology Medicine disc (SinoMed) up 6 th November 2024. article included meta-analysis randomised controlled trials (RCTs) along with Grading Recommendations Assessment, Development Evaluation analysis. Results: total 2355 patients from 21 RCTs were analysed. The pooled results indicated improved quality compared placebo on first postoperative day, as evidenced by reduction Pittsburgh Sleep Quality Index scores [mean difference (MD): −2.69; 95% confidence interval (CI): −3.95, −1.42; P < 0.0001, I 2 = 96%]. Ketamine also second day (MD: −2.45; CI: −3.99, −0.91; 0.002, 96%) during three days −2.90; −4.79, −1.00; 0.003, 97%). In addition, reduced Visual Analogue Scale pain −0.38; −0.55, −0.21; 0.00001, 84%). These suggest reduces PSDs without significantly increasing adverse reactions. However, given high heterogeneity limited evidence this review, should be interpreted caution. Conclusion: indicates administering period can enhance quality. optimal dose, timing method administration remain undetermined, emphasising need further research establish standardised guidelines.

Language: Английский

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