Astrocytes in Rodent Anxiety-Related Behavior: Role of Calcium and Beyond

International Journal of Molecular Sciences, Journal Year: 2025, Volume and Issue: 26(6), P. 2774 - 2774

Published: March 19, 2025

Anxiety is a physiological, emotional response that anticipates distal threats. When kept under control, anxiety beneficial response, helping animals to maintain heightened attention in environments with potential dangers. However, an overestimation of threats can lead excessive expression that, humans, may evolve into disorders. Pharmacological treatments show variable efficacy among patients, highlighting the need for more efforts better understand pathogenesis Mounting evidence suggests astrocytes, type glial cells, are active partners neurons brain circuits and regulation behaviors both physiological pathological conditions. In this review, I summarize current literature on role astrocytes from different regions modulating anxious states, goal exploring novel cerebral mechanisms identify innovative therapeutic targets treatment

Language: Английский

Astrocyte morphological remodeling regulates consciousness state transitions induced by inhaled general anesthesia

Molecular Psychiatry, Journal Year: 2025, Volume and Issue: unknown

Published: April 1, 2025

Language: Английский