Intraoperative hypotension and postoperative risks in non-cardiac surgery: A meta- analysis DOI Creative Commons
Guangqi Qin,

Ming-cheng Du,

Yi Kang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background Postoperative complications are often associated with the severity and duration of intraoperative hypotension. However, optimal approach to manage hypotension during surgery remains controversial. The aim this meta-analysis randomized controlled trials was compare incidence common postoperative different levels management. Methods We searched PubMed, Cochrane Database, Embase from August 2014 2024 for studies comparing management (low [mean arterial pressure < 60 mmHg], moderate [60–75 high [> 75 mmHg]). Only conducted 2014–2024 were included in without language restrictions. Studies following characteristics included: study; involved non-cardiac, non-obstetric surgery; blood strategies; evaluated major complications; acute kidney injury, myocardial altered consciousness, or infection. Data patient age, type surgery, group criteria, adverse events. Mantel–Haenszel method used analysis. primary outcomes complications, including injury. secondary length hospital stay all-cause mortality. Results Of 2160 identified, eight 9108 participants included. No significant differences observed between mean groups (risk ratio = 1.0, 95% confidence interval 0.86–1.18, P 0.96). Sensitivity analysis confirmed these findings. Length hospitalization not significantly (standardized difference -0.39; -0.69 1.31; 0.03). Limited data prevented at lower levels. Conclusion Moderate may reduce stay. available evidence suggests no

Language: Английский

Personalized intraoperative arterial pressure management and mitochondrial oxygen tension in patients having major non-cardiac surgery: a pilot substudy of the IMPROVE trial DOI Creative Commons
Moritz Flick, Christina Vokuhl, Alina Bergholz

et al.

Journal of Clinical Monitoring and Computing, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 7, 2025

Abstract The “Cellular Oxygen METabolism” (COMET) system (Photonics Healthcare, Utrecht, Netherlands) non-invasively measures mitochondrial oxygen tension (mitoPO 2 ) in the skin. effects of general anesthesia and major non-cardiac surgery on mitoPO remain unknown. In this pre-planned pilot substudy “Intraoperative blood pressure Management based individual PRessure profile: impact postOperatiVE organ function” (IMPROVE) trial, we measured from induction until end 19 patients (10 assigned to personalized 9 routine intraoperative arterial management). overall cohort, median (25th 75th percentile) preoperative awake was 63 (53 82) mmHg after 42 (35 59) mmHg. average 39 (30 50) Thirteen (68%) had values below 20 percentage surgical time with < 17 (0 31)%. MitoPO weakly correlated mean (repeated correlation (r rm ( n ); r (984) = 0.26, 95% confidence interval 0.20 0.32; P 0.001), but not meaningfully heart rate -0.05, -0.11 0.01; 0.117). There no important difference between or management (P 0.653). under about a quarter lower than , substantially fluctuated during surgery, transiently decreased two-thirds patients. Personalized – compared did increase . Whether decreases are clinically meaningful warrants further investigation.

Language: Английский

Citations

0
Intraoperative hypotension and postoperative risks in non-cardiac surgery: a meta-analysis DOI Creative Commons
Guangqi Qin,

Ming-cheng Du,

Yi Kang

et al.

BMC Anesthesiology, Journal Year: 2025, Volume and Issue: 25(1)

Published: Feb. 26, 2025

Postoperative complications are often associated with the severity and duration of intraoperative hypotension. However, optimal approach for managing hypotension remains controversial. The aim this meta-analysis randomized controlled trials was to compare incidence common postoperative different treatment threshold We searched PubMed, Cochrane Database, Embase from August 2014 2024 studies comparing (low [mean arterial pressure < 60 mmHg], moderate [60–75 high [> 75 mmHg]). Only conducted during 2014–2024 were included in without language restrictions. Studies following characteristics included: study; involved non-cardiac, non-obstetric surgery; blood management strategies; evaluated major complications; acute kidney injury, myocardial altered consciousness, or infection. Data patient age, type surgery, group criteria, adverse events. Mantel–Haenszel method used analysis. primary outcomes complications, including injury. secondary length hospital stay all-cause mortality. Of 2160 identified, eight 9108 participants included. No significant differences observed between mean groups (risk ratio = 1.0, 95% confidence interval 0.86–1.18, P 0.96). Sensitivity analysis confirmed these findings. Length hospitalization not significantly (standardized difference -0.39; -0.69 1.31; 0.03). Limited data prevented at lower thresholds. results suggest no management.

Language: Английский

Citations

0
„Ich weiß, dass ich nichts weiß“ – Intraoperatives Blutdruckmanagement in der Kinderanästhesiologie DOI

Katharina Röher,

Bernd Saugel

Die Anaesthesiologie, Journal Year: 2024, Volume and Issue: 73(11), P. 721 - 723

Published: Oct. 29, 2024

Citations

0
Intraoperative hypotension and postoperative risks in non-cardiac surgery: A meta- analysis DOI Creative Commons
Guangqi Qin,

Ming-cheng Du,

Yi Kang

et al.

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: Nov. 20, 2024

Abstract Background Postoperative complications are often associated with the severity and duration of intraoperative hypotension. However, optimal approach to manage hypotension during surgery remains controversial. The aim this meta-analysis randomized controlled trials was compare incidence common postoperative different levels management. Methods We searched PubMed, Cochrane Database, Embase from August 2014 2024 for studies comparing management (low [mean arterial pressure < 60 mmHg], moderate [60–75 high [> 75 mmHg]). Only conducted 2014–2024 were included in without language restrictions. Studies following characteristics included: study; involved non-cardiac, non-obstetric surgery; blood strategies; evaluated major complications; acute kidney injury, myocardial altered consciousness, or infection. Data patient age, type surgery, group criteria, adverse events. Mantel–Haenszel method used analysis. primary outcomes complications, including injury. secondary length hospital stay all-cause mortality. Results Of 2160 identified, eight 9108 participants included. No significant differences observed between mean groups (risk ratio = 1.0, 95% confidence interval 0.86–1.18, P 0.96). Sensitivity analysis confirmed these findings. Length hospitalization not significantly (standardized difference -0.39; -0.69 1.31; 0.03). Limited data prevented at lower levels. Conclusion Moderate may reduce stay. available evidence suggests no

Language: Английский

Citations

0