Resistance Evolution and Local Adaptation of Venturia inaequalis to Old and New Generation SDHI Fungicides

Fungal Biology, Journal Year: 2025, Volume and Issue: 129(2), P. 101543 - 101543

Published: Jan. 25, 2025

Language: Английский

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Naturally-Occurring Sulphur Compounds

Published: Jan. 1, 2025

Language: Английский

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Discovery of Novel Pyrazole/Thiazole Derivatives Containing Cyano/Thiocyanato Groups as Fungicide Candidates

Journal of Agricultural and Food Chemistry, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

The introduction of groups with high drug activity is an effective strategy for discovering novel succinate dehydrogenase inhibitor (SDHI) fungicides, providing insights the future design SDHI fungicides higher efficacy and resistance. In this study, we designed synthesized a series pyrazole/thiazole derivatives containing cyano/thiocyanato evaluated them antifungal activity. Some compounds exhibited promising activities against tested fungi, among them, B31 B35 displayed excellent in vitro Rhizoctonia solani EC50 values 1.83 1.08 μg/mL, which were close proximity to commercial fungicide boscalid (EC50 = 0.87 μg/mL). For Altemaria solani, compound (11.14 μg/mL) showed good below (15.31 SAR studies further reveal that induced conjugated interactions between target receptor facilitate electron transport process, contributing its preliminary mechanistic studies, mycelium cells irregular abnormal state under SEM TEM observation caused production accumulation ROS. Molecular docking results SDH enzyme assays indicate has potential be fungicide.

Language: Английский

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Design, synthesis and biological activity evaluation of novel imidazo[5,1‐b]thiazole derivatives containing a pyrazole ring based on the intermediate derivatization method

Pest Management Science, Journal Year: 2025, Volume and Issue: unknown

Published: March 3, 2025

Abstract BACKGROUND A substantial amount of empirical research indicates that the development novel pesticides through intermediate derivatization method can significantly enhance success rate new pesticide creation while reducing and costs. In response to this demand, a series derivatives containing pyrazole imidazo[5,1‐b]thiazole were synthesized by modify imine skeleton, which was found have good antifungal activity in previous work, subjecting it intramolecular nucleophilic substitution reaction. RESULTS These compounds showed performance tests. Compounds 4f 18f [median effective concentration (EC 50 ) values 0.98 0.95 mg L −1 , respectively] had comparable against Sclerotinia sclerotiorum commercial boscalid = 0.82 ). vivo testing compound protective effect on rape leaves at 40 concentration. Scanning (SEM) transmission electron microscopy (TEM) revealed exerted notable detrimental integrity fungal cell membrane, thus activity. Subsequent leakage content, relative conductivity tests, membrane permeability assays reactive oxygen species (ROS) similar results. Moreover, we evaluated lower toxicity aquatic organisms compared positive control acute experiments zebrafish. CONCLUSIONS study, designed derivative ring using subsequently its The highly efficient low may become candidate pesticide. This study provides certain reference value for fungicides based derivatives. © 2025 Society Chemical Industry.

Language: Английский

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Protective effects of commercial propolis ethanolic extracts on maize seeds contaminated with Aspergillus flavus , Aspergillus parasiticus or Fusarium verticillioides

Journal of Apicultural Research, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 9

Published: March 19, 2025

Language: Английский

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