Editorial: Natural product chemical biology DOI
Qi Zhang, Xiaoguang Lei, Hang Yin

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 109, P. 129817 - 129817

Published: May 31, 2024

Indole Derivatives: A Versatile Scaffold in Modern Drug Discovery—An Updated Review on Their Multifaceted Therapeutic Applications (2020–2024) DOI Creative Commons

Xingyou Mo,

Devendra Pratap Rao,

Kirandeep Kaur

et al.

Molecules, Journal Year: 2024, Volume and Issue: 29(19), P. 4770 - 4770

Published: Oct. 9, 2024

Indole derivatives have become an important class of compounds in medicinal chemistry, recognized for their wide-ranging biological activities and therapeutic potential. This review provides a comprehensive overview recent advances the evaluation indole-based last five years, highlighting roles cancer treatment, infectious disease management, anti-inflammatory therapies, metabolic disorder interventions, neurodegenerative management. shown significant efficacy targeting diverse pathways, making them valuable scaffolds designing new drugs. Notably, these demonstrated ability to combat drug-resistant cells pathogens, breakthrough field, offer promising options chronic diseases such as diabetes hypertension. By summarizing key findings exploring underlying mechanisms, this underscores potential indole addressing major healthcare challenges, thereby instilling hope optimism field modern medicine.

Language: Английский

Citations

10
Indole-3-Lactic Acid Derived from Lacticaseibacillus paracasei Inhibits Helicobacter pylori Infection via Destruction of Bacteria Cells, Protection of Gastric Mucosa Epithelial Cells, and Alleviation of Inflammation DOI
Mengke Yao,

Junhan Cao,

Ping Zhang

et al.

Journal of Agricultural and Food Chemistry, Journal Year: 2024, Volume and Issue: 72(28), P. 15725 - 15739

Published: July 8, 2024

Indole-3-lactic acid (ILA) has exhibited antimicrobial properties. However, its role in inhibiting

Language: Английский

Citations

9
Synthesis, biological evaluation and molecular modeling studies of methyl indole-isoxazole carbohydrazide derivatives as multi-target anti-Alzheimer’s agents DOI Creative Commons
Aida Iraji,

Parisa Nikfar,

Mohammad Nazari Montazer

et al.

Scientific Reports, Journal Year: 2024, Volume and Issue: 14(1)

Published: Sept. 10, 2024

Language: Английский

Citations

6
Exploration of endophytic and rhizospheric bacteria of invasive plant Xanthium strumarium L. reveals their potential in plant growth promotion and bacterial wilt suppression DOI

Priyanka Das,

Sampurna Kashyap, Indrani Sharma

et al.

Brazilian Journal of Microbiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 29, 2025

Language: Английский

Citations

0
Design, synthesis and antifungal activity of novel matrine-hydroxamic acid derivatives containing benzene sulfonamide DOI Creative Commons

Suzhen Yan,

Jamal A.H. Kowah,

Qingfeng Long

et al.

RSC Advances, Journal Year: 2025, Volume and Issue: 15(21), P. 16510 - 16524

Published: Jan. 1, 2025

Novel matrine derivative 10g exhibits superior anti- C. albicans activity versus fluconazole by inhibiting biofilm formation and disrupting mature biofilms, potentially targeting SAP protein.

Language: Английский

Citations

0
Editorial: Natural product chemical biology DOI
Qi Zhang, Xiaoguang Lei, Hang Yin

et al.

Bioorganic & Medicinal Chemistry Letters, Journal Year: 2024, Volume and Issue: 109, P. 129817 - 129817

Published: May 31, 2024

Citations

0