Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects DOI Creative Commons
Katharigatta N. Venugopala, Vinuta Kamat

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1258 - 1258

Published: Sept. 24, 2024

Pyrimidine is a moiety that occurs in living organisms and has variety of significant biological properties pharmacology. Due to the easy handling synthesis, easily available precursor, less duration for reaction, not many technical skills are needed. All these factors attract chemists focus more on pyrimidines. Apart from synthesis applications pyrimidines, medicinal have gathered explore pyrimidine scaffolds due their interesting targeting various binding sites. This review delves into diverse activities compounds derived during year 2024. We attempted growing significance derivatives provide new path designing potent molecules.

Language: Английский

Synthesis, single crystal XRD, in vitro evaluation, molecular docking and ADMET studies of cuminaldehyde-thiazolidine-2,4-dione hybrids as potential α-glucosidase inhibitors DOI
Abhik Paul,

Sai Satyaprakash Mishra,

Arnab Sarkar

et al.

Journal of Molecular Structure, Journal Year: 2025, Volume and Issue: unknown, P. 141510 - 141510

Published: Jan. 1, 2025

Language: Английский

Citations

0
Synthesis, Computational, DFT Calculations, Photophysical and Docking Studies of Novel Fluorescent Pyrimidine-Chlorothymol Hybrid as Potent Antimicrobial Agent DOI

S. Chandrasekhar,

B.S. Prathibha,

S Bindu

et al.

Journal of Fluorescence, Journal Year: 2025, Volume and Issue: unknown

Published: March 28, 2025

Language: Английский

Citations

0
Review of Recent Advances in Thiazolidin-4-One Derivatives as Promising Antitubercular Agents (2021–Present) DOI Creative Commons

Wiktoria Drzał,

Nazar Trotsko

Molecules, Journal Year: 2025, Volume and Issue: 30(10), P. 2201 - 2201

Published: May 17, 2025

Tuberculosis (TB) remains one of the leading causes mortality worldwide, exacerbated by emergence multidrug-resistant (MDR) and extensively drug-resistant (XDR) Mycobacterium tuberculosis strains. In pursuit novel therapeutic strategies, thiazolidin-4-one derivatives have gained significant attention due to their structural diversity broad-spectrum biological activities. This review provides a comprehensive summary recent advances (2021–present) in synthesis, structure–activity relationship (SAR), mechanisms action as promising antitubercular agents. A detailed discussion synthetic pathways is presented, including classical multi-component reactions various subclasses such thiazolidine-2,4-diones, rhodanines, pseudothiohydantoins. The SAR analysis highlights key functional groups that enhance antimycobacterial activity, halogen substitutions heterocyclic linkers, while molecular docking vitro studies elucidate interactions with Mtb targets InhA, MmpL3, DNA gyrase. Several compounds demonstrate potent inhibitory effects MIC values lower than or comparable first-line TB drugs, alongside favorable cytotoxicity profiles. These findings underscore potential scaffolds valuable platform for development next-generation therapeutics.

Language: Английский

Citations

0
Pyrimidines: A New Versatile Molecule in the Drug Development Field, Scope, and Future Aspects DOI Creative Commons
Katharigatta N. Venugopala, Vinuta Kamat

Pharmaceuticals, Journal Year: 2024, Volume and Issue: 17(10), P. 1258 - 1258

Published: Sept. 24, 2024

Pyrimidine is a moiety that occurs in living organisms and has variety of significant biological properties pharmacology. Due to the easy handling synthesis, easily available precursor, less duration for reaction, not many technical skills are needed. All these factors attract chemists focus more on pyrimidines. Apart from synthesis applications pyrimidines, medicinal have gathered explore pyrimidine scaffolds due their interesting targeting various binding sites. This review delves into diverse activities compounds derived during year 2024. We attempted growing significance derivatives provide new path designing potent molecules.

Language: Английский

Citations

3