In‐Vitro Antimicrobial, Antidiabetic and Anticancer Activities of Calyptocarpus Vialis Extract and its Integration with Computational Studies

ChemistrySelect, Journal Year: 2024, Volume and Issue: 9(35)

Published: Sept. 12, 2024

Abstract Calyptocarpus vialis ( C. ), a plant of Asteraceae family exhibits nutritional value, antioxidant properties and has potential for various other biomedical applications. The present study is focused to assess the antimicrobial, antidiabetic, anticancer extract its integration with computational studies. antimicrobial activity performed against Staphylococcus aureus S. Bacillus subtilis B. ) pseudomonas aeruginosa P. , Escherichia coli E. bacteria Saccharomyces cerevisiae Candida albicans fungi using disc diffusion method. Maximum Zone Inhibition (ZOI) 37±3.2 35±2.9 mm obtained respectively, whereas ZOI 39±2.8 at dose 500 μg/mL. shows strong α‐amylase inhibition IC 50 ~46.8±0.81 μg/mL inferring about antidiabetic potential. Anticancer checked HCT‐116 DU‐145 cell lines 3‐(4,5‐dimethylthiazol‐2‐yl)‐2,5‐diphenyltetrazolium‐bromide (MTT) assay, which excellent value 38.09±0.65 μg/ml 36.34±1.05 respectively. results are further verified studies considering interaction among phytochemicals selected targets. Extract found potent biological activities promising candidate development new drugs.

Language: Английский

Selective anti-proliferative lignans towards TNBC cells from Knema elegans (Myristicaceae)

Phytochemistry Letters, Journal Year: 2025, Volume and Issue: 66, P. 31 - 34

Published: Feb. 13, 2025

Language: Английский

Site-selective structural modification of toosendanin enables one-step synthesis of 12-hydroxyamoorastatin: A natural tautomeric antitumor lead with low toxicity

Bioorganic Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 108578 - 108578

Published: May 1, 2025

Language: Английский