Intra-articular nanoparticles based therapies for osteoarthritis and rheumatoid arthritis management

Materials Today Bio, Journal Year: 2023, Volume and Issue: 19, P. 100597 - 100597

Published: Feb. 26, 2023

Osteoarthritis (OA) and rheumatoid arthritis (RA) are chronic progressive inflammatory joint diseases that affect a large population worldwide. Intra-articular administration of various therapeutics is applied to alleviate pain, prevent further progression, promote cartilage regeneration bone remodeling in both OA RA. However, the effectiveness intra-articular injection with traditional drugs uncertain controversial due issues such as rapid drug clearance barrier afforded by dense structure cartilage. Nanoparticles can improve efficacy facilitating controlled release, prolonged retention time, enhanced penetration into tissue. This review systematically summarizes nanoparticle-based therapies for RA management. Firstly, we explore interaction between nanoparticles joints, including articular fluids cells. followed comprehensive analysis current designed OA/RA, divided two categories based on therapeutic mechanisms: direct nanoparticles-based delivery systems. We highlight nanoparticle design tissue/cell targeting release before discussing challenges efficient treatment their future clinical translation. anticipate rationally local will be more effective, convenient, safer than approach.

Language: Английский

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Bone-targeted bioengineered bacterial extracellular vesicles delivering siRNA to ameliorate osteoporosis

Composites Part B Engineering, Journal Year: 2023, Volume and Issue: 255, P. 110610 - 110610

Published: Feb. 13, 2023

Language: Английский

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Zero‐Valence Selenium‐Enriched Prussian Blue Nanozymes Reconstruct Intestinal Barrier against Inflammatory Bowel Disease via Inhibiting Ferroptosis and T Cells Differentiation

Advanced Healthcare Materials, Journal Year: 2023, Volume and Issue: 12(12)

Published: Jan. 18, 2023

Abstract The structural disruption of mechanical barrier and dysfunction immune in intestinal, are important factors, that aggravate inflammatory bowel disease (IBD). To tackle this challenge, a multifunctional nanozyme capable scavenging reactive oxygen species (ROS) inhibiting ferroptosis or T cells differentiation for IBD therapy is here reported. In work, zero‐valence selenium‐enriched Prussian blue nanozymes (Se‐HMPB nanozymes) prepared via the hard template method. PB with multi‐enzyme activities can effectively scavenge various ROS tissues. Meanwhile, presence selenium element endows glutathione peroxidase activity Se‐HMPB nanozymes, which inhibit reverse lipid peroxidation intestinal epithelial to protect ulcerative colitis (UC) model. addition, supplementation realize efficient inhibition on Crohn's (CD) model, regulating barrier. Thus, reconstructed UC CD models, depicting great potential alleviate IBD.

Language: Английский

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Stem cell-derived hepatocyte therapy using versatile biomimetic nanozyme incorporated nanofiber-reinforced decellularized extracellular matrix hydrogels for the treatment of acute liver failure

Bioactive Materials, Journal Year: 2023, Volume and Issue: 28, P. 112 - 131

Published: May 18, 2023

Reactive oxygen species (ROS)-associated oxidative stress, inflammation storm, and massive hepatocyte necrosis are the typical manifestations of acute liver failure (ALF), therefore specific therapeutic interventions essential for devastating disease. Here, we developed a platform consisting versatile biomimetic copper oxide nanozymes (Cu NZs)-loaded PLGA nanofibers [email protected] nanofibers) decellularized extracellular matrix (dECM) hydrogels delivery human adipose-derived mesenchymal stem/stromal cells-derived hepatocyte-like cells (hADMSCs-derived HLCs) (HLCs/Cu protected]/dECM). Cu could conspicuously scavenge excessive ROS at early stage ALF, reduce accumulation pro-inflammatory cytokines, herein efficiently preventing deterioration hepatocytes necrosis. Moreover, also exhibited cytoprotection effect on transplanted HLCs. Meanwhile, HLCs with hepatic-specific biofunctions anti-inflammatory activity acted as promising alternative cell source ALF therapy. The dECM further provided desirable 3D environment favorably improved hepatic functions In addition, pro-angiogenesis facilitated integration whole implant host liver. Hence, HLCs/Cu protected]/dECM performed excellent synergistic efficacy mice. This strategy using nanofiber-reinforced in situ is approach therapy shows great potential clinical translation.

Language: Английский

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Tailoring Functional Micromotors for Sensing

Research, Journal Year: 2023, Volume and Issue: 6

Published: Jan. 1, 2023

Micromotors are identified as a promising candidate in the field of sensing benefiting from their capacity autonomous movement. Here, review on development tailoring micromotors for is presented, covering propulsion mechanisms and strategies to applications. First, we concisely summarize mechanism involving fuel-based fuel-free introducing principles. Then, emphasis laid stratagems including speed-based strategy, fluorescence-based other strategies. We listed typical examples different stratagems. After that, introduce applications fields environmental science, food safety, biomedical fields. Finally, discuss challenges prospects tailored sensing. believe that this comprehensive can help readers catch research frontiers thus burst out new ideas.

Language: Английский

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Circadian Clock Regulation via Biomaterials for Nucleus Pulposus

Advanced Materials, Journal Year: 2023, Volume and Issue: 35(32)

Published: April 15, 2023

Circadian clock disorder during tissue degeneration has been considered the potential pathogenesis for various chronic diseases, such as intervertebral disc (IVDD). In this study, circadian clock-regulating biomaterials (ClockMPs) that can effectively activate intrinsic of nucleus pulposus cells (NPCs) in IVDD and improve physiological function NPCs regeneration are fabricated via air-microfluidic technique chemical cross-linking between polyvinyl alcohol modified-phenylboronic acid. vitro experiments verified ClockMPs scavenge reactive oxygen species to maintain a stable microenvironment by promoting binding BMAL1 CLOCK proteins. regulate expression core genes activating PI3K-AKT pathway remodel promote extracellular matrix synthesis. Furthermore, vivo treated with proved regulating NPCs. conclusion, provided novel promising strategy regulation regeneration.

Language: Английский

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Advances in networking droplets

Droplet, Journal Year: 2025, Volume and Issue: unknown

Published: Feb. 18, 2025

Abstract Compartmentalization in living systems, where multiple reactions occur parallel within confined spaces, has inspired the development of droplet networks past decade. These fascinating assemblies offer unique and versatile functions that are unattainable by single droplets have shown their potential as advanced platforms for chemical biological applications. This review highlights recent progress creation application networks, covering strategies generating assembling them into functional networks. Key applications such microreactors, signal conductors, actuators, power sources summarized. We also discuss challenges future trends this field, aiming to narrow gap between fundamental research real

Language: Английский

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Recent Advances and Challenges for Biological Materials in Micro/Nanocarrier Synthesis for Bone Infection and Tissue Engineering

ACS Biomaterials Science & Engineering, Journal Year: 2025, Volume and Issue: unknown

Published: March 11, 2025

Roughly 1.71 billion people worldwide suffer from large bone abnormalities, which are the primary cause of disability. Traditional grafting procedures have several drawbacks that impair their therapeutic efficacy and restrict use in clinical settings. A great deal work has been done to create fresh, more potent strategies. Under these circumstances, a crucial technique for regeneration major lesions emerged: tissue engineering (BTE). BTE involves biomaterials can imitate natural design bone. To yet, no biological material able fully meet parameters perfect implantable material, even though varieties created investigated regeneration. Against this backdrop, researchers focused interest over past few years on subject nanotechnology nanostructures regenerative medicine. The ability nanoengineered particles overcome current constraints strategies─such as decreased cell proliferation differentiation, insufficient mechanical strength materials, production extrinsic factors required effective osteogenesis revolutionized field engineering. effects nanoparticles characteristics application materials main topics our review, summarizes most recent vitro vivo research context BTE.

Language: Английский

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Microfluidics‐Based Microcarriers for Live‐Cell Delivery

Advanced Science, Journal Year: 2025, Volume and Issue: unknown

Published: April 4, 2025

Abstract Live‐cell therapy has emerged as a revolutionary treatment modality, providing novel therapeutic avenue for intractable diseases. However, major challenge in live‐cell is to maintain viability and efficacy during the treatment. Microcarriers are crucial enhancing cell retention, viability, functions by protective scaffold creating supportive environment proliferation metabolism. For microcarrier construction, microfluidic technology demonstrates excellent characteristics terms of controllability over size morphology well potential high‐throughput production. To date, multiple delivery types (e.g., microspheres, microfibers, microneedles) prepared via liquid templates meet different needs. In this review, recent developments microfluidics‐based microcarriers presented. It focused on categorizing structural design microfluidic‐derived cell‐laden microcarriers, summarizing various applications. Finally, an outlook provided future challenges opportunities field.

Language: Английский

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Chinese herb pollen derived micromotors as active oral drug delivery system for gastric ulcer treatment

Bioactive Materials, Journal Year: 2023, Volume and Issue: 32, P. 28 - 36

Published: Sept. 27, 2023

Considerable efforts have been devoted to treating gastric ulcers. Attempts in this field tend develop drug delivery systems with prolonged retention time. Herein, we novel Chinese herb pollen-derived micromotors as active oral system for ulcer. Such are simply produced by asymmetrically sputtering Mg layer onto one side of pollen grains. When exposed juice, the can react hydrogen ions, resulting intensive generation bubbles propel micromotors. Benefiting from autonomous motion and unique spiny structure, our move actively stomach adhere surrounding tissues. Besides, their special architecture endows salient capacity loading releasing. Based on these features, demonstrated that could effective deliver berberine hydrochloride show desirable curative effect ulcer model mice. Therefore, anticipated serve promising carriers clinical applications.

Language: Английский

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