Role of chirality in photoinduced electron transfer in pentapeptide (L)-His-(L/D)-Asp-(L/D)-Ser-Gly-(L)Tyr in solutions DOI
Ilya M. Magin,

Roman S. Lukyanov,

Aleksandra A. Ageeva

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 116164 - 116164

Published: Nov. 1, 2024

Language: Английский

From Self-Assembly to Drug Delivery: Understanding and Exploring Protein Fibrils DOI

Anu Jain,

Manu Lopus, Nand Kishore

et al.

Langmuir, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 2, 2025

It is crucial to comprehend protein misfolding and aggregation in the domains of biomedicine, pharmaceuticals, proteins. Amyloid fibrils are formed when proteins misfold assemble, resulting debilitating illness known as "amyloidosis". This work investigates lysozyme fibrillation with pluronics (F68 F127). The effect on has been studied mechanistically using a combination calorimetric spectroscopic techniques. TEM images ThT binding experiment were used analyze conformation fibrils, results showed that accelerated process. When interact at different stages fibrillation, their pre- postmicellar concentrations show decrease Δ

Language: Английский

Citations

1
The amyloidogenic peptide stretch in human tau, tau306–311 is a promising injectable hydrogelator DOI
Satish Verma, Shinjini Bhattacharya, Sachin Kumar

et al.

Biophysical Chemistry, Journal Year: 2025, Volume and Issue: unknown, P. 107438 - 107438

Published: March 1, 2025

Language: Английский

Citations

0
Assessing amyloid fibrils and amorphous aggregates: A review DOI Creative Commons
Shaik Basha,

Darshan Chikkanayakanahalli Mukunda,

Aparna Pai

et al.

International Journal of Biological Macromolecules, Journal Year: 2025, Volume and Issue: unknown, P. 143725 - 143725

Published: May 1, 2025

Language: Английский

Citations

0
Thermodynamics of oligomerization and Helix-to-sheet structural transition of amyloid β-protein on anionic phospholipid vesicles DOI
Keisuke Ikeda,

Yuuki Sugiura,

Hiroyuki Nakao

et al.

Biophysical Chemistry, Journal Year: 2024, Volume and Issue: 310, P. 107248 - 107248

Published: April 18, 2024

Language: Английский

Citations

3
Critical aggregation concentration and reversibility of amyloid-β (1-40) oligomers DOI Creative Commons
Sara Illodo, Wajih Al‐Soufi, Mercedes Novo

et al.

Archives of Biochemistry and Biophysics, Journal Year: 2024, Volume and Issue: 761, P. 110179 - 110179

Published: Oct. 10, 2024

Language: Английский

Citations

1
Inhibitory Effects of Gliadin Hydrolysates on BACE1 Expression and APP Processing to Prevent Aβ Aggregation DOI Open Access
Chin‐Yu Lin,

Cheng-Hong Hsieh,

Paul B.S. Lai

et al.

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(23), P. 13212 - 13212

Published: Dec. 9, 2024

Alzheimer's disease (AD), a leading neurodegenerative disorder, is closely associated with the accumulation of amyloid-beta (Aβ) peptides in brain. The enzyme β-secretase (BACE1), pivotal Aβ production, represents promising therapeutic target for AD. While bioactive derived from food protein hydrolysates have neuroprotective properties, their inhibitory effects on BACE1 remain largely unexplored. In this study, we evaluated potential gliadin, whey, and casein proteins prepared using bromelain, papain, thermolysin. Through vitro cellular assays, bromelain-hydrolyzed gliadin (G-Bro) emerged as most potent inhibitor, an IC

Language: Английский

Citations

1
Role of chirality in photoinduced electron transfer in pentapeptide (L)-His-(L/D)-Asp-(L/D)-Ser-Gly-(L)Tyr in solutions DOI
Ilya M. Magin,

Roman S. Lukyanov,

Aleksandra A. Ageeva

et al.

Journal of Photochemistry and Photobiology A Chemistry, Journal Year: 2024, Volume and Issue: unknown, P. 116164 - 116164

Published: Nov. 1, 2024

Language: Английский

Citations

0