Ctenophores and parahoxozoans independently evolved complex and functionally diverse sets of voltage-gated K+channels DOI Open Access
Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract The ctenophore species Mnemiopsis leidyi is known to have a large set of voltage-gated K + channels, but little about the functional diversity these channels or evolutionary history this gene family in other species. Here, we searched genomes two additional species, Beroe ovata and Hormiphora californensis , for functionally expressed subset M. channels. We found that last common ancestor three disparate lineages probably had at least 33 Two genes belong EAG family, remaining 31 Shaker form single clade within animal/choanoflagellate phylogeny. additionally evidence 10 transcriptome early branching lineage Euplokamis dunlapae suggesting diversification was already underway evolution. 16 Shakers they encode diverse array conductances with orthologs many classic subtypes cnidarians bilaterians. Ctenophores therefore appear independently evolved much channel shared between

Language: Английский

Ctenophores and parahoxozoans independently evolved functionally diverse voltage-gated K+ channels DOI
Benjamin T. Simonson,

Zhaoyang Jiang,

Joseph F. Ryan

et al.

The Journal of General Physiology, Journal Year: 2025, Volume and Issue: 157(3)

Published: Feb. 27, 2025

The ctenophore species Mnemiopsis leidyi is known to have a large set of voltage-gated K+ channels, but little about the functional diversity these channels or their evolutionary history in other species. Here, we searched genomes two additional species, Beroe ovata and Hormiphora californensis, for functionally expressed subset M. channels. We found that last common ancestor three disparate lineages probably had at least 33 Two genes belong EAG family, remaining 31 Shaker family form single clade within animal/choanoflagellate phylogeny. additionally evidence 10 transcriptome early branching lineage Euplokamis dunlapae, suggesting diversification was already underway evolution. 16 Shakers they encode diverse array conductances with orthologs many classic subtypes cnidarians bilaterians. Analysis data show are wide variety cell types, including neurons, muscle, comb cells, colloblasts. Ctenophores therefore appear independently evolved much channel shared between

Language: Английский

Citations

2
A broad survey of choanoflagellates revises the evolutionary history of the Shaker family of voltage-gated K + channels in animals DOI Creative Commons
Timothy Jegla, Benjamin T. Simonson, J. David Spafford

et al.

Proceedings of the National Academy of Sciences, Journal Year: 2024, Volume and Issue: 121(30)

Published: July 17, 2024

The Shaker family of voltage-gated K

Language: Английский

Citations

5
How the Blind Watchmaker messed around with potassium channels DOI
Lawrence Salkoff

The Journal of General Physiology, Journal Year: 2025, Volume and Issue: 157(3)

Published: March 19, 2025

Studies of potassium channel evolution from the Jegla group contribute valuable insights into complexity in electrical signaling and conservation repurposing key molecular components throughout evolutionary history.

Language: Английский

Citations

0
Ctenophores and parahoxozoans independently evolved complex and functionally diverse sets of voltage-gated K+channels DOI Open Access
Benjamin T. Simonson, Zhaoyang Jiang, Joseph F. Ryan

et al.

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2024, Volume and Issue: unknown

Published: Dec. 11, 2024

Abstract The ctenophore species Mnemiopsis leidyi is known to have a large set of voltage-gated K + channels, but little about the functional diversity these channels or evolutionary history this gene family in other species. Here, we searched genomes two additional species, Beroe ovata and Hormiphora californensis , for functionally expressed subset M. channels. We found that last common ancestor three disparate lineages probably had at least 33 Two genes belong EAG family, remaining 31 Shaker form single clade within animal/choanoflagellate phylogeny. additionally evidence 10 transcriptome early branching lineage Euplokamis dunlapae suggesting diversification was already underway evolution. 16 Shakers they encode diverse array conductances with orthologs many classic subtypes cnidarians bilaterians. Ctenophores therefore appear independently evolved much channel shared between

Language: Английский

Citations

0