Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface DOI Creative Commons
Miharu Maeda, Masashi Arakawa, Kota Saito

et al.

Traffic, Journal Year: 2025, Volume and Issue: 26(1-3)

Published: Jan. 1, 2025

The endoplasmic reticulum (ER)-Golgi interface is essential for directing the transport of proteins synthesized in ER to Golgi apparatus via ER-Golgi intermediate compartment, as well recycling back ER. This facilitated by various components, including COPI and COPII coat protein complexes particle complex. Recently, pathway has gained attention due emerging evidence nonvesicular mechanisms regulation trafficking through liquid-liquid phase separation. Numerous diseases have been linked mutations localized at interface, highlighting need comprehensive analysis these conditions. review examines disease phenotypes associated with dysfunctional factors explores their cellular effects, providing insights into potential therapeutic strategies.

Language: Английский

Disease‐Associated Factors at the Endoplasmic Reticulum–Golgi Interface DOI Creative Commons
Miharu Maeda, Masashi Arakawa, Kota Saito

et al.

Traffic, Journal Year: 2025, Volume and Issue: 26(1-3)

Published: Jan. 1, 2025

The endoplasmic reticulum (ER)-Golgi interface is essential for directing the transport of proteins synthesized in ER to Golgi apparatus via ER-Golgi intermediate compartment, as well recycling back ER. This facilitated by various components, including COPI and COPII coat protein complexes particle complex. Recently, pathway has gained attention due emerging evidence nonvesicular mechanisms regulation trafficking through liquid-liquid phase separation. Numerous diseases have been linked mutations localized at interface, highlighting need comprehensive analysis these conditions. review examines disease phenotypes associated with dysfunctional factors explores their cellular effects, providing insights into potential therapeutic strategies.

Language: Английский

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