Journal of Stomatology Oral and Maxillofacial Surgery, Journal Year: 2024, Volume and Issue: unknown, P. 102131 - 102131
Published: Nov. 1, 2024
Language: Английский
Journal of Reproductive Immunology, Journal Year: 2025, Volume and Issue: 169, P. 104538 - 104538
Published: May 8, 2025
Language: Английский
Citations
0
Reproductive Biology and Endocrinology, Journal Year: 2025, Volume and Issue: 23(1)
Published: May 14, 2025
Language: Английский
Citations
0
Theranostics, Journal Year: 2024, Volume and Issue: 14(6), P. 2345 - 2366
Published: Jan. 1, 2024
Rationale: Primordial follicles are limited in number and cannot be regenerated, dormant primordial reversed once they enter a growth state.Therefore, the length of female reproductive lifespan depends on orderly progression selective activation follicles, mechanism which remains unclear.Methods: We used human ovarian cortical biopsy specimens, granulosa cells from diminished reserve (DOR) patients, Hdac6-overexpressing transgenic mouse model, RNA sequencing to analyze crucial roles histone deacetylase 6 (HDAC6) fertility preservation follicle activation.Results: In present study, we found that HDAC6 was highly expressed most follicles.The expression reduced accompanying senescence ovaries.Overexpression Hdac6 delayed rate activation, thereby prolonging lifespan.Short-term inhibition promoted follicular development humans mice.Mechanism studies revealed directly interacted with NGF, reducing acetylation modification NGF accelerating its ubiquitination degradation.Consequently, protein level maintained dormancy follicles. Conclusions:The physiological significance high is reduce prevent maintain fertility.Reduced increases activating their contributing reproduction.Our study provides clinical reference value for preservation.
Language: Английский
Citations
3
Modern Agriculture, Journal Year: 2024, Volume and Issue: 2(1)
Published: May 30, 2024
Abstract Proper nutrition is essential for sustaining optimal reproductive function in both humans and ruminants. Studies have shown that undernutrition overnutrition can negatively impact human processes. However, the Mediterranean diet, with its balanced nutrient‐rich composition, recognised positive effects on reproduction. In context of ruminants, a well‐balanced diet equally crucial achieving peak performance. Grazing, which allows ruminants to feed natural pasture open environments, contrasts indoor feeding, conducted more controlled settings. A dietary approach vital successful reproduction ruminant animals, combination grazing feeding has been identified as an effective strategy enhance their success. This review emphasises outcomes populations, advocating practices improve success across species. thorough understanding complex relationship between health offer valuable insights into enhancing fertility efficiency various contexts.
Language: Английский
Citations
3
Frontiers in Nutrition, Journal Year: 2024, Volume and Issue: 11
Published: Oct. 30, 2024
This study aims to understand the association between body roundness index (BRI) and female infertility prevalence. Infertility is a public health concern with significant implications for individuals' well-being rights.
Language: Английский
Citations
3
Frontiers in Endocrinology, Journal Year: 2024, Volume and Issue: 15
Published: Dec. 12, 2024
Background Visceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and infertility remains ambiguous. Methods This study employed cross-sectional design analyzed data from National Health Nutrition Examination Survey (NHANES, 2012–2016). Weighted logistic regression models were utilized to examine association Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted assess diagnostic efficacy of these for Results Individuals experiencing exhibited markedly elevated levels Chinese Adiposity Index (CVAI) (108.30 vs. 69.86, P <0.001) (VAI) (1.68 1.35, <0.001). When considered as continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, <0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, =0.259), demonstrated significant with risk Consistent findings also evident after dividing participants into 4 subgroups based quartiles. Additionally, ROC curves indicated that most robust value compared other indices. Subgroup analyses revealed across different populations. Conclusion Females faced significantly heightened in United States. holds promise valuable tool stratifying
Language: Английский
Citations
1
Quality in Sport, Journal Year: 2024, Volume and Issue: 21, P. 53937 - 53937
Published: Aug. 28, 2024
Introduction Women who want to get pregnant soon often ask their doctors how prepare best. During such a visit, usually mention folic acid supplementation, check-up with the dentist and gynaecologist or vaccinations. However, it is also worth pointing out importance of lifestyle factors that affect fertility fetal development. Modifying daily habits can improve naturally make getting faster. An increasing number studies are being published on nutrition, physical activity, sleep, stress, stimulants other women's reproductive health. This article summary current state knowledge in this area. Aim study The aim review literature summarize association between female function. Material methods research based researches from PubMed platform. We searched articles describing connection potentially modifiable women’s fertility. Search terms included keywords: „lifestyle”, „female fertility”, „obesity”, „sleep”, „nutrition”, „diet”, „stress”, „physical activity”, „smoking”, „alcohol”, „weight loss”, „reproductive health”.
Language: Английский
Citations
0
Applied Sciences, Journal Year: 2023, Volume and Issue: 13(24), P. 13028 - 13028
Published: Dec. 6, 2023
Infertility is a major issue at present and common disease that exists in both male female reproductive systems, described as failure to attain pregnancy. The most important physiological phenomenon for establishing clinical pharmacy defined infertility (FI). Obesity enhances the risks many chronic disorders, especially causing high risk women’s health. relationship between infertile women thrombophilia characterized by abnormal blood coagulation. Among thrombophilic variants, Factor V Leiden (FVL), prothrombin (PT) methyl tetrahydrofolate reductase (MTHFR) genes such G1691A (rs6020), G20210A (rs1799963) C677T (rs1801133) are commonly studied majority of human diseases. In this case–control study, we investigated role variants G1691A, FVL, PII MTHFR Saudi women. Based on sample size calculation, 100 control (fertile) were selected based inclusion exclusion criteria. Genotyping was performed with polymerase chain reaction followed precise restriction enzymes, which can accurately detect nucleotide amendment C677T. required statistics applied case (infertile) document age, weight BMI found be comparison None genotypes, genetic models or allele frequencies associated SNPs (p > 0.05). Furthermore, regression model ANOVA analysis also showed negative statistical associations. combination genotypes among positive associations recessive = 0.0006). Finally, GMDR moderate gene–gene interaction, dendrogram depletion models. study confirmed have no may not involved
Language: Английский
Citations
1
Revista Ibero-Americana de Humanidades, Ciências e Educação, Journal Year: 2024, Volume and Issue: 9(12), P. 1268 - 1279
Published: Jan. 26, 2024
A obesidade é uma condição de saúde globalmente prevalente, associada a série complicações e impactos negativos em diversos aspectos da vida. Entre as ramificações menos discutidas, mas igualmente importantes, encontra-se o impacto na fertilidade gestação das mulheres. relação entre reprodutivas tem sido objeto estudo, cirurgia bariátrica emergiu como intervenção significativa para perda peso casos extrema. No entanto, implicações dessa demandam análise mais aprofundada. compreensão dos efeitos nesse contexto crucial fornecer informações embasadas mulheres obesas que consideram ou já passaram por esse procedimento, assim profissionais lidam com reprodutiva. Objetivo: Este estudo visa realizar revisão sistemática literatura avaliar obesas. Buscaremos sintetizar analisar estudos recentes, publicados nos últimos 10 anos, presentes nas bases dados PubMed, Scielo Web of Science, utilizando cinco descritores principais: "cirurgia bariátrica", "obesidade", "fertilidade", "gestação" "complicações". O objetivo visão abrangente sobre evidências científicas disponíveis, contribuindo desdobramentos desse procedimento fases Metodologia: seguirá diretrizes do checklist PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). busca será conduzida mencionadas, artigos anos. Serão incluídos abordem Critérios inclusão englobam observacionais ensaios clínicos controlados. excluídos não se enquadram no escopo tema, amostras representativas aqueles cuja metodologia atenda aos critérios qualidade estabelecidos. Resultados: Os resultados desta revelam variedade descobertas relacionadas ao Dentre os principais tópicos, destacam-se alterações hormonais, taxas concepção, gestacionais desfechos neonatais. crítica selecionados proporciona benefícios desafios associados à específico. Conclusão: Em síntese, esta destaca necessidade abordagem individualizada considerar idade Embora possa oferecer significativos peso, potenciais gestação. Profissionais devem estar cientes dessas complexidades aconselhar pacientes bariátrica, enfatizando multidisciplinar otimizar reprodutivos global mulher obesa.
Citations
0
Toxicology and Applied Pharmacology, Journal Year: 2024, Volume and Issue: 486, P. 116930 - 116930
Published: April 16, 2024
Language: Английский
Citations
0