Published: Jan. 1, 2024
Language: Английский
Polymers, Journal Year: 2024, Volume and Issue: 16(12), P. 1691 - 1691
Published: June 14, 2024
The placement of endotracheal prostheses is a procedure used to treat tracheal lesions when no other surgical options are available. Unfortunately, this technique remains controversial. Both silicon and metallic stents with unpredictable success rates, as they have advantages but also disadvantages. Typical side effects include restenosis due epithelial hyperplasia, obstruction granuloma formation. Repeat interventions often required. Biodegradable promising in the field cardiovascular biomechanics not yet approved for use respiratory system. aim present study summarize important information evaluate role different geometrical features fabrication new tracheo-bronchial prosthesis prototype, which should be biodegradable, adaptable patient’s lesion producible by 3D printing. A parametric design subsequent computational analysis using finite element method carried out. Two stent designs parameterized analyzed. biodegradable material chosen simulations polylactic acid. Experimental tests conducted assessing its mechanical properties. key parameters on radial force investigated. results allow us elucidate pitch angle, wire thickness number cells or units, among parameters, force. This work may useful ad hoc airway according patient type lesion.
Language: Английский
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Published: Jan. 1, 2024
Bioprinting, akin to 3D printing, employs cell-laden hydrogels such as GelMA (Gelatine Methacrylate) and Alginate instead of plastic or resin create biological structures. The printing process followed by subsequent tissue maturation is known 4D bioprinting, where the fourth dimension time. Ensuring adequate consistent oxygen, O2, supply within bioprint volume over entire period crucial, even transient hypoxia can impact cellular behavior phenotypes. However, fully developed vasculature remains an unresolved technical challenge. Several approaches chemically (peroxides) biologically (photosynthesis) generate oxygen during have been proposed. a comprehensive evaluation optimization these methods not currently possible due lack quantitative longitudinal O2 imaging modality. electron paramagnetic resonance (EPRI) demonstrated be method choice solve problem oxygenation in prolonged EPRI permits noninvasive mapping using incorporate bioinks probes. Two types probes utilized: water soluble triarylmehyl (trityls) stable radicals solid lithium octa-nbutoxy-phthalocyanine (LiNc-BuO) particles. Incorporation materials modifies its chemical optical properties. For example, LiNc-BuO absorbing light affects photopolymerization. Also, bioprinting Trityls react with formed intermediate radicals. Part presented work was dedicated understanding that includes addition into commonly used GelMa alginate bioinks. Bioprinting done locally digital processing (DLP) extrusion bioprinters. oximetry performed built instrument. Both acellular constructs were successfully printed imaged. Experiments revealed previously unreported phenomenon depletion presence residual photoinitiator. Oxygen consumption rates HEK293T cells structures quantified. changing levels murine macrophage-laden freeform reversible embedding suspended (FRESH) methodology. computed analyzing consecutive EPR images time dimension. Given incorporation bioink, proper control experiments evaluating temporal probe stability signal intensity bioink conducted. In conclusion, we've shown feasibility integrating paving way for diverse applications various molecular spin These findings are foundational advancing technologies dynamics engineering.
Language: Английский
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Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown
Published: Jan. 1, 2024
Language: Английский
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Journal of Intelligent Manufacturing, Journal Year: 2024, Volume and Issue: unknown
Published: Dec. 3, 2024
Language: Английский
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0
Published: Jan. 1, 2024
Language: Английский
Citations
0