A review of computational optimization of bone scaffold architecture: Methods, challenges, and perspectives DOI Creative Commons
Ali H. Foroughi,

Caleb Valeri,

Mir Jalil Razavi

et al.

Progress in Biomedical Engineering, Journal Year: 2024, Volume and Issue: 7(1), P. 012003 - 012003

Published: Oct. 16, 2024

Abstract The design and optimization of bone scaffolds are critical for the success tissue engineering (BTE) applications. This review paper provides a comprehensive analysis computational methods scaffold architecture, focusing on balance between mechanical stability, biological compatibility, manufacturability. Finite element method (FEM), fluid dynamics (CFD), various algorithms discussed their roles in simulating refining designs. integration multiobjective topology has been highlighted developing that meet multifaceted requirements BTE. Challenges such as need consideration manufacturing constraints incorporation degradation regeneration models into process have identified. underscores potential advanced tools additive techniques evolving field BTE, aiming to improve patient outcomes regeneration. reliability current is examined, with suggestions incorporating non-deterministic approaches vivo validations enhance practical application optimized scaffolds. concludes call further research artificial intelligence-based advance optimization.

Language: Английский

3D Bioprinting of Natural Materials and Their AI-Enhanced Printability: A Review DOI
Soumaya Grira, Mohammad Sayem Mozumder, Abdel‐Hamid I. Mourad

et al.

Bioprinting, Journal Year: 2025, Volume and Issue: unknown, P. e00385 - e00385

Published: Jan. 1, 2025

Language: Английский

Citations

2
AI-driven 3D bioprinting for regenerative medicine: From bench to bedside DOI
Huajin Zhang, Xianhao Zhou, Yongcong Fang

et al.

Bioactive Materials, Journal Year: 2024, Volume and Issue: 45, P. 201 - 230

Published: Nov. 23, 2024

Language: Английский

Citations

11
Innovative technologies for the fabrication of 3D/4D smart hydrogels and its biomedical applications - A comprehensive review DOI
Uday Shashikumar,

Aditya Saraswat,

Kalim Deshmukh

et al.

Advances in Colloid and Interface Science, Journal Year: 2024, Volume and Issue: 328, P. 103163 - 103163

Published: May 7, 2024

Language: Английский

Citations

8
Characterization and Machine Learning-Driven Property Prediction of a Novel Hybrid Hydrogel Bioink Considering Extrusion-Based 3D Bioprinting DOI Creative Commons

Rokeya Sarah,

Kory Schimmelpfennig,

Riley Rohauer

et al.

Gels, Journal Year: 2025, Volume and Issue: 11(1), P. 45 - 45

Published: Jan. 7, 2025

The field of tissue engineering has made significant advancements with extrusion-based bioprinting, which uses shear forces to create intricate structures. However, the success this method heavily relies on rheological properties bioinks. Most bioinks use shear-thinning. While a few component-based efforts have been reported predict viscosity bioinks, impact rate vastly ignored. To address gap, our research presents predictive models using machine learning (ML) algorithms, including polynomial fit (PF), decision tree (DT), and random forest (RF), estimate bioink based component weights rate. We utilized novel composed varying percentages alginate (2-5.25%), gelatin TEMPO-Nano fibrillated cellulose (0.5-1%) at rates from 0.1 100 s-1. Our study analyzed 169 measurements 80% training 20% validation data. results, coefficient determination (R2) mean absolute error (MAE), showed that RF algorithm-based model performed best: [(R2, MAE) = (0.99, 0.09), (R2, PF (0.95, 0.28), DT (0.98, 0.13)]. These serve as valuable tools for formulation optimization, allowing researchers determine effective viscosities without extensive experimental trials accelerate engineering.

Language: Английский

Citations

1
Advancements in 3D Printing Technologies for Personalized Treatment of Osteonecrosis of the Femoral Head DOI Creative Commons
Tingting Chen,

Lincong Luo,

Jiaying Li

et al.

Materials Today Bio, Journal Year: 2025, Volume and Issue: 31, P. 101531 - 101531

Published: Feb. 5, 2025

Three-dimensional (3D) printing technology has shown significant promise in the medical field, particularly orthopedics, prosthetics, tissue engineering, and pharmaceutical preparations. This review focuses on innovative application of 3D addressing challenges osteonecrosis femoral head (ONFH). Unlike traditional hip replacement surgery, which is often suboptimal for younger patients, offers precise localization necrotic areas ability to create personalized implants. By integrating advanced biomaterials, this a promising strategy approach early hip-preserving treatments. Additionally, 3D-printed bone engineering scaffolds can mimic natural environment, promoting regeneration vascularization. In future, potential extends combining with artificial intelligence optimizing treatment plans, developing materials enhanced bioactivity compatibility, translating these innovations from laboratory clinical practice. demonstrates how uniquely addresses critical ONFH treatment, including insufficient vascularization, poor mechanical stability, limited long-term success conventional therapies. introducing gradient porous scaffolds, bioactive material coatings, AI-assisted design, work outlines novel strategies improve interventions. These advancements not only enhance efficacy but also pave way findings into applications.

Language: Английский

Citations

1
Recent Developments in Bio-Ink Formulations Using Marine-Derived Biomaterials for Three-Dimensional (3D) Bioprinting DOI Creative Commons
Zied Khiari

Marine Drugs, Journal Year: 2024, Volume and Issue: 22(3), P. 134 - 134

Published: March 16, 2024

3D bioprinting is a disruptive, computer-aided, and additive manufacturing technology that allows the obtention, layer-by-layer, of complex structures. This believed to offer tremendous opportunities in several fields including biomedical, pharmaceutical, food industries. Several processes bio-ink materials have emerged recently. However, there still pressing need develop low-cost sustainable with superior qualities (excellent mechanical, viscoelastic thermal properties, biocompatibility, biodegradability). Marine-derived biomaterials, polysaccharides proteins, represent viable renewable source for formulations. Therefore, focus this review centers around use marine-derived biomaterials formulations bio-ink. It starts general overview followed by description most commonly used bioprinting, special attention paid chitosan, glycosaminoglycans, alginate, carrageenan, collagen, gelatin. The challenges facing application within biomedical pharmaceutical along future directions are also discussed.

Language: Английский

Citations

7
3D printing of an artificial intelligence-generated patient-specific coronary artery segmentation in a support bath DOI Creative Commons

Serkan Sokmen,

Soner Çakmak, İlkay Öksüz

et al.

Biomedical Materials, Journal Year: 2024, Volume and Issue: 19(3), P. 035038 - 035038

Published: April 16, 2024

Abstract Accurate segmentation of coronary artery tree and personalized 3D printing from medical images is essential for CAD diagnosis treatment. The current literature on relies solely generic models created with different software or manually segmented images. Moreover, there are not many studies examining the bioprintability a model generated by artificial intelligence (AI) complex branched structures. In this study, deep learning algorithms transfer have been employed accurate to generate printable segmentations. We propose combination printing, which accurately segments prints vascular patterns in arteries. Then, we performed AI-generated fabrication bifurcated hollow structure. Our results indicate improved performance aid Dice overlap score 0.86 test set 10 tomography angiography regions were printed into Pluronic F-127 support bath using alginate + glucomannan hydrogel. successfully fabricated structures high length wall thickness accuracy, however, outer diameters vessels bifurcation point differ models. extrusion unnecessary material, primarily observed when nozzle moves left right vessel during can be mitigated adjusting speed. shape accuracy also designing multi-axis printhead that change angle three dimensions. Thus, study demonstrates potential use AI-segmented and, further improved, used patient-specific implants.

Language: Английский

Citations

4
Advanced strategies in 3D bioprinting for vascular tissue engineering and disease modelling using smart bioinks DOI Creative Commons

Joeng Ju Kim,

Dong‐Woo Cho

Virtual and Physical Prototyping, Journal Year: 2024, Volume and Issue: 19(1)

Published: Aug. 30, 2024

Advanced three-dimensional (3D) bioprinting technology enables the precise production of complex vascular structures and biomimetic models, driving advancements in tissue engineering disease mechanism research. At core this is smart bioink, which suitable for fabricating models that can be vascularised to meet property requirements various tissues. Examples bioinks include decellularized extracellular matrix (dECM), photocrosslinkable, reversible, microgel-based biphasic (MB) bioinks, whose mechanical properties tuned through external stimuli. This tuning helps generate high-resolution complex-shaped networks essential cell survival functional maturation. review explores advanced 3D strategies using spatially controlled perfusable vitro emphasising reconstruction within bioprinted models. It also discusses challenges future prospects, suggesting could serve as alternatives traditional animal modelling drug screening.

Language: Английский

Citations

4
A Path towards SDGs: Investigation of the Challenges in Adopting 3D Concrete Printing in India DOI Creative Commons

Bandoorvaragerahalli Thammannagowda Shivendra,

Shahaji,

S. Sathvik

et al.

Infrastructures, Journal Year: 2024, Volume and Issue: 9(9), P. 166 - 166

Published: Sept. 23, 2024

In recent years, three dimensional concrete printing (3DCP) has gained traction as a promising technology to mitigate the carbon footprint associated with construction industry. However, despite its environmental benefits, studies frequently overlook impact on social sustainability and overall influence project success. This research investigates how strategic decisions by firms shape tradeoffs between economic, environmental, in context of 3DCP adoption. Through interviews 20 Indian industry leaders, it was found that companies primarily invest for automation skilled workforce development, rather than solely reasons. The lack incentives sustainable practices government procurement regulations emerges significant barrier widespread adoption 3DCP. Our study identifies five key strategies employ promote through proposes actionable measures intervention stimulate advancement. Addressing these issues is crucial realizing full societal benefits technology.

Language: Английский

Citations

4
Three-Dimensional Printing/Bioprinting and Cellular Therapies for Regenerative Medicine: Current Advances DOI Creative Commons
Ana Catarina Sousa, Rui Alvites, Bruna Lopes

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(1), P. 28 - 28

Published: Jan. 16, 2025

The application of three-dimensional (3D) printing/bioprinting technologies and cell therapies has garnered significant attention due to their potential in the field regenerative medicine. This paper aims provide a comprehensive overview 3D technology therapies, highlighting results diverse medical applications, while also discussing capabilities limitations combined use. synergistic combination printing cellular been recognised as promising innovative approach, it is expected that these will progressively assume crucial role treatment various diseases conditions foreseeable future. review concludes with forward-looking perspective on future impact technologies, revolutionize medicine through enhanced tissue repair organ replacement strategies.

Language: Английский

Citations

0