Exploring Mechanical Features of 3D Head and Neck Cancer Models DOI Creative Commons

A EVANGELISTA,

Franca Scocozza, Michele Conti

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 74 - 74

Published: Feb. 20, 2025

Head and neck squamous cell carcinoma (HNSCC) presents significant challenges in oncology due to its complex biology poor prognosis. Traditional two-dimensional (2D) culture models cannot replicate the intricate tumor microenvironment, limiting their usefulness studying disease mechanisms testing therapies. In contrast, three-dimensional (3D) vitro provide more realistic platforms that better mimic architecture, mechanical features, cellular interactions of HNSCC. This review explores properties 3D developed for HNSCC research. It highlights key techniques, such as spheroids, organoids, bioprinted tissues, emphasizing ability simulate critical characteristics like hypoxia, drug resistance, metastasis. Particular attention is given stiffness, elasticity, dynamic behavior, highlighting how these emulate native tissues. By enhancing physiological relevance studies, offer potential revolutionize research facilitate development effective, personalized therapeutic strategies. bridges gap between preclinical clinical applications by summarizing providing guidance developing systems both biological advancing innovation cancer therapy.

Language: Английский

Exploring Mechanical Features of 3D Head and Neck Cancer Models DOI Creative Commons

A EVANGELISTA,

Franca Scocozza, Michele Conti

et al.

Journal of Functional Biomaterials, Journal Year: 2025, Volume and Issue: 16(3), P. 74 - 74

Published: Feb. 20, 2025

Head and neck squamous cell carcinoma (HNSCC) presents significant challenges in oncology due to its complex biology poor prognosis. Traditional two-dimensional (2D) culture models cannot replicate the intricate tumor microenvironment, limiting their usefulness studying disease mechanisms testing therapies. In contrast, three-dimensional (3D) vitro provide more realistic platforms that better mimic architecture, mechanical features, cellular interactions of HNSCC. This review explores properties 3D developed for HNSCC research. It highlights key techniques, such as spheroids, organoids, bioprinted tissues, emphasizing ability simulate critical characteristics like hypoxia, drug resistance, metastasis. Particular attention is given stiffness, elasticity, dynamic behavior, highlighting how these emulate native tissues. By enhancing physiological relevance studies, offer potential revolutionize research facilitate development effective, personalized therapeutic strategies. bridges gap between preclinical clinical applications by summarizing providing guidance developing systems both biological advancing innovation cancer therapy.

Language: Английский

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