A neural signature for the subjective experience of threat anticipation under uncertainty

Nature Communications, Journal Year: 2024, Volume and Issue: 15(1)

Published: Feb. 20, 2024

Abstract Uncertainty about potential future threats and the associated anxious anticipation represents a key feature of anxiety. However, neural systems that underlie subjective experience threat under uncertainty remain unclear. Combining an uncertainty-variation paradigm allows precise modulation level momentary arousal during functional magnetic resonance imaging (fMRI) with multivariate predictive modeling, we train brain model accurately predicts intensity test it across 9 samples (total n = 572, both gender). Using publicly available datasets, demonstrate whole-brain signature specifically is not sensitive in predicting pain, general or unspecific emotional autonomic arousal. The also functionally spatially distinguishable from representations fear negative affect. We develop sensitive, generalizable, specific neuroimaging marker for uncertain can facilitate development.

Language: Английский

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Functional connectivity profiles of the default mode and visual networks reflect temporal accumulative effects of sustained naturalistic emotional experience

NeuroImage, Journal Year: 2023, Volume and Issue: 269, P. 119941 - 119941

Published: Feb. 13, 2023

Determining and decoding emotional brain processes under ecologically valid conditions remains a key challenge in affective neuroscience. The current functional Magnetic Resonance Imaging (fMRI) based emotion studies are mainly on brief isolated episodes of induction, while sustained experience naturalistic environments that mirror daily life experiences scarce. Here we used 12 different 10-minute movie clips as emotion-evoking procedures n = 52 individuals to explore emotion-specific fMRI connectivity (FC) profiles the whole-brain level at high spatial resolution (432 parcellations including cortical subcortical structures). Employing machine-learning cross validation allowed investigate FC contributing classification can accurately distinguish happiness sadness generalize across subjects, clips, parcellations. Both network-based subnetwork-based results suggested manifests distributed representation multiple networks, rather than single network or subnetwork. Further, showed Visual Network (VN) Default Mode (DMN) associated especially VN-DMN, exhibited strong contribution classification. To further estimate temporal accumulative effect long-term movie-based video-evoking emotions, divided 10-min episode into three stages: early stimulation (1∼200 s), middle (201∼400 late (401∼600 s) examined performance stages. We found contributes most (accuracy=85.32%, F1-score=85.62%) compared stages, implying continuous exposure lead more intense emotions enhance distinguishable representations. present work demonstrated presented these expressions may play roles generation modulation emotions. These findings elucidated importance adaptations for during contexts open new venues imaging contributions conditions.

Language: Английский

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A neurofunctional signature of subjective disgust generalizes to oral distaste and socio-moral contexts

Nature Human Behaviour, Journal Year: 2024, Volume and Issue: 8(7), P. 1383 - 1402

Published: April 19, 2024

Language: Английский

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The Angiotensin Antagonist Losartan Modulates Social Reward Motivation and Punishment Sensitivity via Modulating Midbrain-Striato-Frontal Circuits

Journal of Neuroscience, Journal Year: 2022, Volume and Issue: 43(3), P. 472 - 483

Published: Dec. 6, 2022

Social deficits and dysregulations in dopaminergic midbrain-striato-frontal circuits represent transdiagnostic symptoms across psychiatric disorders. Animal models suggest that interactions between the dopamine (DA) renin-angiotensin system (RAS) may modulate learning reward-related processes. The present study therefore examined behavioral neural effects of Angiotensin II type 1 receptor (AT1R) antagonist losartan on social reward punishment processing humans. A preregistered randomized double-blind placebo-controlled between-subject pharmacological design was combined with a incentive delay (SID) functional MRI (fMRI) paradigm during which subjects could avoid or gain reward. Healthy volunteers received single-dose (50 mg, n = 43, female 17) placebo ( 44, 20). We evaluated reaction times (RTs) emotional ratings as activation connectivity outcomes. Relative to placebo, modulated time arousal differences On level losartan-enhanced motivational salience rewards accompanied by stronger ventral striatum-prefrontal anticipation. Losartan increased reward-neutral difference tegmental area (VTA) attenuated VTA associated bilateral insula response outcome phase. Thus, approach-avoidance motivation versus via modulating distinct core nodes circuits. findings document modulatory role these processes, suggesting promising treatment target alleviate dysregulations. SIGNIFICANCE STATEMENT anhedonia characterize several mental disorders have been linked brain. Based initial from animal we here combine blockade demonstrate AT1R enhances attenuates negative impact communication for first an important humans render novel

Language: Английский

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Neurocognitive mechanisms of mental imagery-based disgust learning

Behaviour Research and Therapy, Journal Year: 2024, Volume and Issue: 175, P. 104502 - 104502

Published: Feb. 21, 2024

Language: Английский

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Reduction of Aversive Learning Rates in Pavlovian Conditioning by Angiotensin II Antagonist Losartan: A Randomized Controlled Trial

Biological Psychiatry, Journal Year: 2024, Volume and Issue: 96(4), P. 247 - 255

Published: Feb. 2, 2024

BackgroundAngiotensin receptor blockade (ARB) has been linked to aspects of aversive learning and memory formation, the prevention post-traumatic stress disorder symptom development.MethodsWe investigate influence ARB losartan on Pavlovian conditioning using a probabilistic paradigm. In double-blind, randomised placebo-controlled design, we tested 45 (18 female) healthy volunteers during Baseline session, after application or placebo (Drug session) Follow-up session. On each participants engaged in task where they had predict probability an electrical stimulation every trial while true shock contingencies repeatedly switched between phases high low threat. Computational reinforcement models were used dynamics.ResultsAcute administration significantly reduced participants' adjustment both low-to-high high-to-low threat changes. This was driven by rates group drug session compared baseline. The 50mg dose did not induce reduction blood pressure change reaction times, ruling out general attention engagement. Decreased expectations maintained follow up 24hrs later.ConclusionsThis study shows that acutely reduces environments, highlighting potential role renin-angiotensin system anxiety development.

Language: Английский

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Oxytocin reduces subjective fear in naturalistic social contexts via enhancing top-down middle cingulate-amygdala regulation and brain-wide connectivity

Research Square (Research Square), Journal Year: 2024, Volume and Issue: unknown

Published: July 2, 2024

Accumulating evidence from animal and human studies suggests a fear-regulating potential of the neuropeptide oxytocin (OT), yet clinical translation into novel interventions for pathological fear requires behavioral neurofunctional characterization under close-to-real life conditions. Here, we combined naturalistic fMRI-design inducing high immersive experience in social non-social contexts with preregistered between-subjects randomized double-blind placebo-controlled intranasal OT trial (24 IU, n\(=\)67 healthy men). reduced subjective small or moderate effect sizes, respectively. In contexts, enhanced left middle cingulate cortex (lMCC) activation its functional connectivity contralateral amygdala, both neural indices significantly inversely associated following OT. On network level, communication between dorsal attention (DAN) fronto-parietal (FPN) default-mode (DMN) as well on more fine-grained level brain-wide communication. These findings indicate fear-reducing conditions pronounced effects highlighting value treatment option disorders characterized by excessive situations.

Language: Английский

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Whole-Brain fMRI Functional Connectivity Signatures Predict Sustained Emotional Experience in Naturalistic Contexts

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2022, Volume and Issue: unknown

Published: Nov. 9, 2022

Abstract Determining and decoding emotional brain processes under ecologically valid conditions remains a key challenge in affective neuroscience. The current functional magnetic resonance imaging (fMRI) based emotion studies are mainly on brief isolated episodes of induction, while sustained experience naturalistic environments that mirror daily life experiences scarce. Here we use 10-minute movie clips as emotion-evoking procedures n=52 individuals to explore emotion-specific fMRI connectivity (FC) profiles the whole-brain level at high spatial resolution (400 atlas parcels). Employing machine-learning cross validation allowed develop predictive FC can accurately distinguish happiness sadness generalize across movies subjects. Both network-based subnetwork-based prediction results suggest manifests distributed representation multiple networks, rather than single network or subnetwork. Further, show Visual Network (VN) Default Mode (DMN) associated especially VN-DMN, exhibit strong contribution prediction. To further estimate cumulative effect long-term movie-based video-evoking emotions, divide 10-min episode into three stages: early stimulation (1 ~ 200 s), middle (201 400 late (401 600 s) examine performance different stages. We found has stronger ability (accuracy=85.32%, F1-score=85.62%) compared stages, implying continuous exposure lead more intense emotions enhance distinguishable representations. present work demonstrates presented these expressions may play roles generation modulation emotions. These findings elucidate importance adaptations for during contexts open new venues contributions conditions.

Language: Английский

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Using Multivariate Neurofunctional Signatures to Dissect the Specific Mental Processes Modulated by Novel Pharmacological Targets

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2023, Volume and Issue: 8(3), P. 233 - 234

Published: March 1, 2023

Language: Английский

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Of Soldiers and Their Ghosts: Are We Ready for a Review of PTSD Evidence?

BioMed, Journal Year: 2023, Volume and Issue: 3(4), P. 484 - 506

Published: Nov. 10, 2023

Psychosocial trauma has accompanied mankind since time immemorial and been sufficiently portrayed in art literature to suggest that posttraumatic stress disorder may be as old combat itself. Since war is more frequent human history than peace, public health measures are confined mitigating the detrimental impact of battlefield experiences on participants. At present, PTSD outcome studies show mixed results, marked by high nonresponse rates, therapy dropout, completed suicide, suggesting novel strategies urgently needed. Those us who work routinely with veterans have noted an increasing trend patients preferring mindfulness-based therapies opposed trauma-centered treatments, such prolonged exposure or trauma-focused cognitive behavioral therapy. Preference for mindfulness over trauma-based appears coincide shift research focus from amygdala fear insular cortex interoceptive awareness. Therefore, rethinking pathology driven recent findings neurons this cortical area not only regulate cardiac rhythm but also record past intestinal inflammations. These discoveries likely explain comorbidity stress-related disorders premature endothelial senescence a dysfunctional barrier. Moreover, identification cholinergic anti-inflammatory pathway revelation cells express alpha-7 nicotinic receptors brought prevention early detection within reach. In narrative review, we discuss relationship between vascular aging, gut barrier disruption, PTSD. We examine link faulty awareness, surmising hypertension decreased heart rate variability risk factors, while lipopolysaccharide, lipopolysaccharide binding protein, soluble CD14, microbial cell-free DNA, acyloxyacyl hydrolase, IL22 comprise markers disorder.

Language: Английский

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