The Serotonin 4 Receptor Subtype: A Target of Particular Interest, Especially for Brain Disorders

International Journal of Molecular Sciences, Journal Year: 2024, Volume and Issue: 25(10), P. 5245 - 5245

Published: May 11, 2024

In recent years, particular attention has been paid to the serotonin 4 receptor, which is well expressed in brain, but also peripherally various organs. The cerebral distribution of this receptor conserved across species, with high densities basal ganglia, where they are by GABAergic neurons. 5-HT4 present cortex, hippocampus, and amygdala, carried glutamatergic or cholinergic Outside central nervous system, notably gastrointestinal tract. wide undoubtedly contributes its involvement a plethora functions. addition, modulation influences release serotonin, other neurotransmitters such as acetylcholine dopamine. This considerable asset, can therefore play direct indirect beneficial role disorders. One main advantages that it mediates much faster antidepressant anxiolytic action than classical selective reuptake inhibitors. Another major benefit activation enhances cognitive performance, probably via acetylcholine. expression altered eating disorders, agonist negatively regulates food intake. Additionally, although modified certain movement-related still yet be determined whether plays key their pathophysiology. Finally, there no longer any need demonstrate value agonists pharmacological management

Language: Английский

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EEG Markers of Cognitive Performance in Bipolar Disorder –A Systematic Review

Neuroscience & Biobehavioral Reviews, Journal Year: 2025, Volume and Issue: unknown, P. 106157 - 106157

Published: April 1, 2025

People with bipolar disorder (BD) may experience impairing cognitive deficits, even in remission. Electroencephalographic (EEG) measures can depict neurophysiological activity high temporal resolution. They could therefore be an adequate method to pinpoint the impairments BD, facilitating understanding of when exactly processing is disrupted and what systems are involved. In absence a previous literature examination, this systematic review aimed synthesize evidence associations between EEG identify electrophysiological markers performance BD. A search across PubMed, EMBASE, APA PsycInfo Cochrane Library until November 2023 was undertaken studies which direct correlation any continuous measure participants BD reported. narrative synthesis approach used present identified correlations, five (attention speed, working memory, episodic executive function, intellectual capacity) four domains (event-related potentials (ERP), spectral, connectivity other measures). total 16 articles describing 15 were included review. Six significant correlations. Most correlations reported ERP attention speed performance, several functioning one within memory capacity domain respectively. However, most conflicting (different or mood states) no consistent studies. The majority non-significant. As yet robust people known. This highlights heterogeneity participant characteristics need for standardization. Further homogeneous methods groups help establish associations.

Language: Английский

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Framewise multi-echo distortion correction for superior functional MRI

bioRxiv (Cold Spring Harbor Laboratory), Journal Year: 2023, Volume and Issue: unknown

Published: Nov. 29, 2023

Abstract Functional MRI (fMRI) data are severely distorted by magnetic field (B0) inhomogeneities which currently must be corrected using separately acquired map data. However, changes in the head position of a scanning participant across fMRI frames can cause B0 field, preventing accurate correction geometric distortions. Additionally, maps corrupted movement during their acquisition, distortion altogether. In this study, we use phase information from multi-echo (ME) to dynamically sample due fluctuating inhomogeneity acquiring multiple echoes single EPI readout. Our approach, MEDIC (Multi-Echo DIstortion Correction), accurately estimates related distortions for each frame Here, demonstrate that MEDIC’s framewise produces improved alignment anatomy and decreases impact motion on resting-state functional connectivity (RSFC) maps, higher data, when compared prior gold standard approach (i.e., TOPUP). Enhanced with MEDIC, without requirement collection, furthers advantage over single-echo fMRI.

Language: Английский

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Insights into the advances in therapeutic drugs for neuroinflammation-related diseases

International Journal of Neuroscience, Journal Year: 2023, Volume and Issue: unknown, P. 1 - 26

Published: Sept. 19, 2023

Studies have shown that neurodegenerative diseases such as AD and PD are related to neuroinflammation. Neuroinflammation is a common inflammatory condition can lead variety of dysfunction in the body. At present, it no medications specifically approved prevent or cure neuroinflammation, so even though many drugs temporarily control neurological symptoms but one reverse progress let al.one completely Therefore, urgent develop new drug development for neuroinflammation treatment. In this review, we highlight therapeutic advancement field disorders, by focusing on impact treatment has these conditions, effective their latest research reviewed according signaling pathway, well prospect clinical application also discussed. The purpose review enable specialists better understand mechanisms underlying anti-inflammatory drugs, promote diseases, further provide references neurologists.

Language: Английский

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Clinical Translation of 5-HT4 Receptor Agonism: A Promising Antidepressant and Procognitive Target

Biological Psychiatry Cognitive Neuroscience and Neuroimaging, Journal Year: 2023, Volume and Issue: 8(11), P. 1068 - 1069

Published: Nov. 1, 2023

Language: Английский

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