Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients DOI
Joseph Kambeitz,

H. Häcker,

Linnea Hoheisel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Patients with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory higher-order regions. In this study, we investigate disruptions the hierarchical organization of networks patients psychotic affective disorders. We derived gradients, low dimensional representations rs-FC that capture cortical hierarchy, a large patient sample including clinical high-risk for (CHR-P) patients, recent-onset (ROP) (ROD) healthy controls (HC). examined regional alterations, network-level differentiation their relationship to symptoms. addition, linked case-control differences receptor expression maps explore underlying neurobiological mechanisms. All groups exhibited visual-to-sensorimotor gradient, while only ROP showed association-to-sensory gradient. CHR-P lower values ventral attention network. Additionally, combined higher somatomotor network, reduced gradient range altered between-network dispersion. ROD within-network dispersion attentional range. Correlational analysis revealed weak associations measures functioning, visual dysfunctions cognition. Furthermore maps, suggesting involvement neurotransmitter systems these disruptions. Our findings reveal transdiagnostic disease-specific organization. These indicate deficits integration across psychiatric diseases, highlighting role disease processes.

Language: Английский

Disrupted Hierarchical Functional Brain Organization in Affective and Psychotic Disorders: Insights from Functional Brain Gradients DOI
Joseph Kambeitz,

H. Häcker,

Linnea Hoheisel

et al.

Research Square (Research Square), Journal Year: 2025, Volume and Issue: unknown

Published: April 17, 2025

Patients with psychosis and depression show widespread alterations in brain resting-state functional connectivity (rs-FC), affecting both sensory higher-order regions. In this study, we investigate disruptions the hierarchical organization of networks patients psychotic affective disorders. We derived gradients, low dimensional representations rs-FC that capture cortical hierarchy, a large patient sample including clinical high-risk for (CHR-P) patients, recent-onset (ROP) (ROD) healthy controls (HC). examined regional alterations, network-level differentiation their relationship to symptoms. addition, linked case-control differences receptor expression maps explore underlying neurobiological mechanisms. All groups exhibited visual-to-sensorimotor gradient, while only ROP showed association-to-sensory gradient. CHR-P lower values ventral attention network. Additionally, combined higher somatomotor network, reduced gradient range altered between-network dispersion. ROD within-network dispersion attentional range. Correlational analysis revealed weak associations measures functioning, visual dysfunctions cognition. Furthermore maps, suggesting involvement neurotransmitter systems these disruptions. Our findings reveal transdiagnostic disease-specific organization. These indicate deficits integration across psychiatric diseases, highlighting role disease processes.

Language: Английский

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