Psilocybin and other Psychedelics DOI
Alfred P. Kaye,

Benjamin Kelmendi,

Merangely N. Rivera

et al.

Elsevier eBooks, Journal Year: 2024, Volume and Issue: unknown

Published: Jan. 1, 2024

Language: Английский

Psilocybin: From Psychiatric Pariah to Perceived Panacea DOI
Gregory A. Fonzo, Aaron Wolfgang,

Bryan Barksdale

et al.

American Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 182(1), P. 54 - 78

Published: Jan. 1, 2025

The authors critically examine the evidence base for psilocybin administered with psychological support/therapy (PST) in treatment of psychiatric disorders and offer practical recommendations to guide future research endeavors.

Language: Английский

Citations

3

Psychedelics in Psychiatry: Oh, What A Trip! DOI
Gregory A. Fonzo, Charles B. Nemeroff, Ned H. Kalin

et al.

American Journal of Psychiatry, Journal Year: 2025, Volume and Issue: 182(1), P. 1 - 5

Published: Jan. 1, 2025

Language: Английский

Citations

2

1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI): From an Obscure to Pivotal Member of the DOX Family of Serotonergic Psychedelic Agents – A Review DOI Creative Commons
Richard A. Glennon, Małgorzata Dukat

ACS Pharmacology & Translational Science, Journal Year: 2024, Volume and Issue: 7(6), P. 1722 - 1745

Published: May 8, 2024

1-(2,5-Dimethoxy-4-iodophenyl)-2-aminopropane (DOI, or DOX where X = −I) was first synthesized in 1973 a structure–activity study to explore the effect of various aryl substituents on then newly identified, and subsequently controlled, hallucinogenic agent 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM, −CH3). Over time, DOI found be serotonin (5-HT) receptor agonist using peripheral 5-HT tissue assays later, following identification multiple families central receptors, an at 5-HT2 receptors rat and, then, human brain. Today, classical hallucinogens, currently referred as serotonergic psychedelic agents, are receiving considerable attention for their potential therapeutic application neuropsychiatric disorders including treatment-resistant depression. Here, we review, historical current developments that led becoming unique, perhaps landmark, research.

Language: Английский

Citations

10

Spirituality as a Therapeutic Approach for Severe Mental Illness: Insights from Neural Networks DOI Creative Commons
Henderikus Knegtering, Richard Bruggeman, S K Spoelstra

et al.

Religions, Journal Year: 2024, Volume and Issue: 15(4), P. 489 - 489

Published: April 16, 2024

This article explores the link between spirituality/religiosity and mental health from a clinical neuroscience perspective, taking into account advancements in neuroimaging. Specifically, it examines how spirituality influences treatment of illness, emphasizing importance neuronal networks cognitive emotional processes, with focus on default mode network (DMN) brain. The discussion role managing disorders alterations DMN may provide insight impact health. By also discussing spiritual non-spiritual meditation, as well experiences facilitated by use psychedelics psychiatry associated brain networks, we aim to elaborate limitations within psychiatry.

Language: Английский

Citations

6

Serotonergic neuromodulation of synaptic plasticity DOI
Guilherme Shigueto Vilar Higa, Felipe José Costa Viana, José Fernando de Oliveira

et al.

Neuropharmacology, Journal Year: 2024, Volume and Issue: 257, P. 110036 - 110036

Published: June 12, 2024

Language: Английский

Citations

4

Clinical and preclinical evidence of psilocybin as antidepressant. A narrative review DOI Creative Commons
I. Erkizia-Santamaría, Igor Horrillo, J. Javier Meana

et al.

Progress in Neuro-Psychopharmacology and Biological Psychiatry, Journal Year: 2025, Volume and Issue: unknown, P. 111249 - 111249

Published: Jan. 1, 2025

Language: Английский

Citations

0

Regulatory Challenges of Integrating Psychedelics into Mental Health Sector DOI Creative Commons

Kerem Kemal Soylemez,

Emma Marie de Boo,

Joanne Lusher

et al.

Psychoactives, Journal Year: 2025, Volume and Issue: 4(2), P. 11 - 11

Published: April 22, 2025

Psychedelic substances have recently emerged as a promising method for treating mental health conditions, despite history of stigmatization and restriction in use. The present review synthesizes existing literature on the therapeutic potential psychedelics such LSD, psilocybin, MDMA addressing specific conditions like depression, anxiety, addiction. On reviewing literature, it became apparent that when administered controlled settings with psychological support, can induce profound insights, leading to long-lasting positive changes mood, cognition, behaviour. This discusses ethical, social, regulatory challenges linked using within sector across different countries, how these might influence societal beliefs towards their efficacy Further research would be beneficial eliciting deeper understanding use field health, development standardized administration protocols thorough appreciation implications long-term outcomes. revolutionize treatment while underlining urgent need rigorous scientific inquiry this topic ethical considerations surrounding purposes.

Language: Английский

Citations

0

History of psychedelic drug science and molecular pharmacology DOI
David E. Nichols, Charles D. Nichols

International review of neurobiology, Journal Year: 2025, Volume and Issue: unknown

Published: Jan. 1, 2025

Language: Английский

Citations

0

Exploring the Role of Psychedelic Experiences on Wellbeing and Symptoms of Disordered Eating DOI Creative Commons

Nadine Loh,

David Luke

Psychoactives, Journal Year: 2025, Volume and Issue: 4(1), P. 7 - 7

Published: March 4, 2025

Accumulating psychedelic research has demonstrated a potential for improving mental health and wellbeing, yet studies in the context of eating disorders (EDs) are limited. This study aims to explore subjective effects experiences gain insight into benefits risks people with EDs. Semi-structured interviews were conducted eight adults aged 25–54 (mean age = 36.9), reporting have had EDs psychedelics both naturalistic clinical settings. Participants multiple diagnoses suffered chronic EDs, onset 13), diagnosed (N 7) undiagnosed 1). Reports cessation or reduction ED symptoms unanimous long-lasting seven, two participants recovery attributed use. Two reported relapsing, environmental factors months following. Thematic analysis resulted superordinate themes, each comprising three subordinate themes. The first theme, ‘Exploring’ via ‘gateway healing’, illustrates mental, emotional, transcendental elements experiences. second ‘Transformation’ being ‘able do work’, cognitive behavioural outcomes, retrospective safety perceptions. These findings may provide more in-depth information on what can obtain from use drugs inform robust investigations psychedelic-assisted therapy treatment

Language: Английский

Citations

0

“Ontological shocks”: new transformations for sustainability through psychedelic tourism DOI Creative Commons
Alexandra Coghlan, Girish Prayag

Journal of Sustainable Tourism, Journal Year: 2025, Volume and Issue: unknown, P. 1 - 25

Published: April 18, 2025

Language: Английский

Citations

0